1. Wild-Type and Genetically Improved Strains of Dairy Origin Probiotic as Potential Treatments for Intestinal Mucositis
- Author
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Gwénaël Jan, Rodrigo Dias de Oliveira Carvalho, Yves Le Loir, Flávia Figueira Aburjaile, Vasco Azevedo, Molecular and Cellular Laboratory, General Biology Department, Institute of Biological Sciences, Federal University of Minas Gerais, Laboratory of Genetics and Plant Biotechnology, Genetics Department, Federal University of Pernambuco [Recife], Science et Technologie du Lait et de l'Oeuf (STLO), Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)
- Subjects
prebiotique ,Biology ,human health ,allégations nutritionnelles et de santé ,produit laitier ,Microbiology ,law.invention ,pharmacotherapy ,03 medical and health sciences ,Probiotic ,0302 clinical medicine ,intestin ,law ,[SDV.IDA]Life Sciences [q-bio]/Food engineering ,chimiothérapie ,Mucositis ,medicine ,inflammation gastrointestinale ,030304 developmental biology ,0303 health sciences ,Wild type ,santé humaine ,probiotique ,medicine.disease ,3. Good health ,[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology ,dairy product ,030220 oncology & carcinogenesis ,inflammation du tube digestif ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition ,probiotic - Abstract
The use of probiotic bacteria derived from fermented foods has been explored by the scientific community as alternative strategies for the treatment of several diseases, mainly regarding intestinal dysfunction. One of the most relevant inflammatory diseases affecting the alimentary tract, for which no current intervention is entirely successful, is mucositis. In this review article, we summarize the most recent proof-of-concept studies dealing with the therapeutic use of dairy origin probiotics, for the treatment of gastrointestinal mucositis. Furthermore, we discuss several approaches for the improvement of the classical therapeutic rationale, such as supplementation with prebiotics and genetic engineering along with the respective translational issues, which may be crucial for the successful transposition of these therapeutic strategies for clinical use.
- Published
- 2019