Search

Your search keyword '"Walkenhorst, William F."' showing total 1 results
Start Over Author "Walkenhorst, William F." Journal journal of the american chemical society
1 results on '"Walkenhorst, William F."'

1. Broad-spectrum antimicrobial peptides by rational combinatorial design and high-throughput screening: the importance of interfacial activity

Author

Rathinakumar, Ramesh, Walkenhorst, William F., and Wimley, William C.

Subjects
Anti-infective agents -- Chemical properties, Anti-infective agents -- Structure, Lipid membranes -- Structure, Lipid membranes -- Chemical properties, Peptides -- Chemical properties, Chemistry
Abstract

The biological activity of the selected peptides from the combinatorial library in bacteria, fungi and mammalian cells is studied to characterize the selected peptides and to compare the activity of antimicrobial peptides (AMPs) in vitro and in vivo. The analysis has shown that the methods focusing on screening peptide libraries in vitro for membranes with the appropriate interfacial activity has enabled the design, selection and discovery of novel, potent and broad-spectrum membrane-active antibiotics.

Published
2009

Catalog

Books, media, physical & digital resources
See catalog results