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Low intensity focused ultrasound (LIFU) has demonstrated the ability to inhibit nervous system. However, no study has done on left stellate ganglion (LSG) and post-infarction ventricular arrhythmias (VAs). Eight dogs were anesthetized and divided into LIFU group (with LIFU, n=4) and Sham group (

Late sodium current (INa,L) is increased in many pathological conditions, e.g., ischemic heart. Enhanced Na,L has been shown to elicit after-depolarizations and triggered arrhythmic activity. Eleclazine (GS-6615) has the properties of reducing INa,L in atrial and ventricular tissue and minimal

To study the mechanism of the transforming growth factor-β(TGF-β) in Ginsenoside Rb1 against the replicative senescence of human umbilical vein endothelial cells (HUVECs). Replicative Senescence model was established by serial subcultivation of primary HUVECs in vitro. Then, Cells were divided

Nuclear factor-κB plays a critical role in endothelial senescence. However, the mechanisms remain unclear. We hypothesized that the alteration of S-Nitrosylation of NF-κB p65 may contribute to hydrogen peroxide-induced endothelial cell senescence. The human umbilical vein endothelial cells (

To investigate the effects of Ginsenoside Rb1 on Homocysteine(HCY)-induced endothelial dysfunction and inflammatory response. With the informed consents of puerperants, the normal fetal umbilical cords were obtained through uterine-incision delivery in Third Affiliated Hospital, Sun Yat-sun

Objectives We investigated whether naloxone could reduce macrophage activation and influence atherosclerotic lesion formation in mice. Background Macrophages play an important role in the inflammatory process in atherosclerosis. Naloxone could inhibit activation of microglia, the resident macrophage in the nervous system. Methods The anti-inflammatory effect of naloxone was evaluated by stimulating the macrophage cell culture and FVB mice with lipopolysaccharide or oxidized low-density lipoprotein with and without naloxone pretreatment. Apolipoprotein-E (apoE)-deficient mice received naloxone injection for 10 weeks, and the severity of aortic atherosclerosis was measured. The left common carotid arteries of C57BL/6 mice were ligated near the carotid bifurcation. The mice then received naloxone injection for 4 weeks after ligation, and the severity of neointima formation was evaluated. Results Naloxone pretreatment significantly suppressed the production of tumor necrosis factor-α (TNF-α), interleukin-6, monocyte chemoattractant protein-1, and superoxide in macrophages after stimulation. In FVB mice, naloxone reduced the TNF-α level in circulation, inflammatory cell infiltration in lungs, and superoxide production in aorta. Naloxone injection significantly decreased the severity of aortic atherosclerosis in the apoE-deficient mice and carotid neointima formation in the C57BL/6 mice after ligation. Conclusions Naloxone, with its novel anti-inflammatory effect, significantly reduces atherosclerosis and neointima formation in mice.

To study the mechanism of the oxidative damage in Ginsenoside Rb1 against the intrinsic aging of mouse brain. Female C57BL/6 mice were divided into three groups randomly: control group(4 months, n=12); model group(24 months, n=12) and drug group(24 months, n=12). In drug group, ginsenoside Rb1(20mg

To investigate the relationship between apolipoprotein (apo) A and the extent of coronary artery lesions in Chinese type 2 diabetics with coronary heart disease. Totally 184 type 2 diabetic patients diagnosed with coronary heart disease by coronary angiography were enrolled. The level of apoA was

Overweight and obesity have become a public health problem. In obese state, abundant fatty free acids (FFA) were released from hyperplastic adipose tissue and were release to adipocytes, skeletal muscle, liver, then leading to adipocytes inflammation and insulin resistance. Ginsenoside Rb1 was

To evaluate the expressions of soluble vascular endothelial growth factor receptor 2 (sVEGFR2) and visfatin in plasma of hypertensive and hypertensive diabetic patients. And to explore the correlation between sVEGFR2 and visfatin in the whole study population. In this cross-sectional study, eighty

Cilostazol is an antiplatelet agent with vasodilating effect. We have reported that it could promote angiogenesis and enhance endothelial progenitor cells (EPCs) functions. In this study, we investigated the vasculo–angiogenic effect of cilostazol on EPCs in patients with peripheral arterial

To study the mechanism of the mTOR in Ginsenoside Rb1 against the intrinsic aging of mouse brain. Female C57BL/6 mice were divided into three groups randomly: control group(4 months, n=12); model group(24 months, n=12) and drug group(24 months, n=12). In drug group, ginsenoside Rb1(20mg.kg-1.d-1)

To detect the levels of visfatin and superoxide dismutase (SOD) in plasma of hypertensive and hypertensive diabetic patients. And to explore the correlation between visfatin and SOD in the whole study population. In this cross-sectional study, eighty-eight cases were enrolled, which were divided