Search

Erythema nodosum leprosum (ENL) is the commonest manifestation of type 2 lepra reaction (T2LR) due to immune complex-mediated inflammation in patients of lepromatous (LL) and borderline lepromatous (BL) leprosy. Reversal reaction in multibacillary leprosy patients following MDT with and without immunotherapy with candidate anti leprosy vaccine, Mycobacterium w. Lepr Rev 1993; 64: 219 - 226. [Extracted from the article]

Since the therapeutic use of targeted therapies increases, it is important that patients and physicians are aware of potential UVA-mediated photosensitivity reactions, which might occur late in the course of treatment. Furthermore, this case illustrates the potential of encorafenib-induced persistent photosensitivity to UVA as our patient demonstrated UVA-triggered erythema during photopatch testing as late as 2 months after withdrawal of the drug. Dear Editor, The BRAF inhibitor encorafenib was approved in 2018 for the therapy of advanced BRAF-mutant melanoma. [Extracted from the article]

However, vaccine-related erythema nodosum was rare, and the pathogenesis of vaccine-associated erythema nodosum remained unknown. All patients developed rashes within 1 week of vaccination, and the rash was mainly distributed in the anterior tibial area of both calves. Erythema nodosum following SARS-CoV-2 vaccine. [Extracted from the article]

As vaccination rates in leprosy endemic areas rise, so may the likelihood of higher rates of ENL. Erythema nodosum leprosum (ENL) is a type 2 immunological reaction, indicative of bacterial-rich leprosy. The patient in this manuscript has given written informed consent to the publication of his case details. [Extracted from the article]

The patient had no personal or family history of systemic or skin diseases and had not taken any drug related to the development of EN; therefore, it was hypothesized a causal correlation between COVID-19 vaccination and the appearance of skin manifestations. The patients in this manuscript have given written informed consent to the publication of their case details. Erythema nodosum following the first dose of ChAdOx1-S nCoV-19 vaccine. [Extracted from the article]

Importance BRAF inhibitors have been licensed for the therapy of BRAF-mutated melanoma. Recently, inflammatory skin lesions clinically resembling erythema nodosum have been reported as therapy side-effects that may lead to treatment discontinuation. Objective To identify and characterize cases with BRAF inhibitor-associated erythema nodosum-like inflammatory skin lesions and development of an algorithm for their management. Design and Setting Retrospective chart review of melanoma patients treated with BRAF inhibitors in 14 departments of Dermatology in Germany and Austria and PubMed search for cases in the literature. Results Sixteen patients were identified who developed erythema nodosum-like lesions under BRAF inhibitor therapy; 14 had received vemurafenib and two dabrafenib plus trametinib. The most frequently involved body sites were the legs. Histopathology was performed in five cases and revealed panniculitis in three and vasculitis in two patients respectively. Arthralgia and fever were associated symptoms in 44% and 31% of patients respectively. Inflammatory symptoms led to discontinuation of treatment in three patients, while in the majority of cases symptomatic management was sufficient. Skin lesions finally resolved despite continued BRAF inhibitor therapy in seven patients. In the literature, 19 additional patients with similar cutaneous appearance under BRAF inhibitors could be identified. An algorithm for the management of such lesions is proposed. Conclusion Erythema nodosum-like skin lesions histologically correspond to panniculitis and/or vasculitis. Symptomatic treatment may be sufficient. However, additional work-up and interruption of BRAF inhibitor therapy may be necessary in severe cases which are commonly associated with systemic symptoms. [ABSTRACT FROM AUTHOR]

The article presents a case study of a 4-year-old girl having dermatitis associated with cervical lymphadenopathy who was later diagnosed with Erythema nodosum. Topics discussed include Direct mycological examination by light microscopy showing ectoendothrix parasitism of the hair, treatment with griseofulvin being continued and combined with oral betamethasone, hair growth in areas of hair loss after eight weeks of therapy and Erythema nodosum being an acute form of panniculitis with lesions.

Leprosy reactions (LR) are acute inflammatory episodes that manifest as skin lesions, neuritis and systemic symptoms in patients with leprosy infection. Of the LR cases, 65 (89%) corresponded to lepromatous leprosy (LL) and 8 (11%) to borderline lepromatous leprosy (BL). The leprosy type most frequently associated with ENL was lepromatous leprosy in 59 (80.8%). [Extracted from the article]

Objectives To investigate skin disorders related to Epstein Barr Virus (EBV) seroconversion and review the literature on this topic. Patients and methods 77 patients admitted to three Departments (Dermatology, Infectious Diseases, Pediatrics) presented clinical and laboratory (Enzyme Linked Immunosorbent Assay) findings of EBV primary infection. 54/77 (70.1%), ranging in age from 9 months to 41 years and suffering from various skin disorders, were selected. Results 8/54 presented Infantile papular acrodermatitis (Gianotti-Crosti syndrome); 42/54 exanthema, 2/54 acute urticaria, 1/54 erythema multiforme, 1/54 erythema nodosum. Conclusion After reviewing the available literature on the subject and in the light of these findings, it is possible to assert that EBV-primary infection is not infrequently associated with skin symptoms. Clinicians may sometimes understimate the problem, and it would be useful to include EBV serology among the tests for the diagnosis of reactive cutaneous diseases occurring in subjects under 30 years old. [ABSTRACT FROM AUTHOR]

The article presents a case study of three Hispanic women who were presented with bilateral lower extremity nodules and unilateral breast plaques that developed after breast lesions. Core biopsies of the breast plaques in all patients showed acute inflammation and lymphohistiocytic with granulomas. Erythema nodosum (EN) was resolved in all patients after treatment with topical agents and indomethacin.

A 27-year-old woman presented with erythema nodosum on her legs. After treatment, only slight hyperpigmentation persisted at the sites of the previous erythema nodosum patches. Three months later the patient observed, at the same sites, the growth of dense tufts of fine black hairs. [ABSTRACT FROM AUTHOR]

AbstractWe describe the case of a 45-year-old man with atopy who developed marked inflammatory lesions on the bearded area of the face caused by Tricophyton rubrum, an anthropophilic fungus not frequently correlated with kerion of the face. After starting therapy with griseofulvin, he developed typical lesions of erythema nodosum on both legs. We discuss how these lesions could be correlated with the kerion of the face. [ABSTRACT FROM AUTHOR]