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1. Assessment of the QoL in Italian menopausal women: comparison between HRT users and non-users

Author

Genazzani, A. R., Nicolucci, A., Campagnoli, C., Crosignani, P., Nappi, C., Serra, G. B., Bottiglioni, E., Cianci, A., Aloysio, D. D., Sarti, C. D., Gambacciani, M., Monteleone, P., Genazzani, Alessandro, Guaschino, S., Palumbo, G., Petraglia, F., Schonauer, S., Volpe, Annibale, Paolantonio, T. D., Nagni, M., Tempesta, A., Coronel, G. A., Qualità, P. D., Genazzani, Ar, Nicolucci, A, Campagnoli, C, Crosignani, P, Nappi, Carmine, Serra, Gb, Bottiglioni, E, Cianci, A, De Aloysio, D, Donati Sarti, C, Gambacciani, M, Monteleone, P, Genazzani, Ad, Guaschino, S, Palumbo, G, Petraglia, F, Schonauer, S, Volpe, A, Di Paolantonio, T, Nagni, M, Tempesta, A, and Coronel, Ga

Subjects
Gerontology, medicine.medical_specialty, Multivariate analysis, Psychometrics, HRT, Health Status, General Biochemistry, Genetics and Molecular Biology, Quality of life, Surveys and Questionnaires, Epidemiology, Humans, Medicine, Gynecology, Response rate (survey), business.industry, Public health, Estrogen Replacement Therapy, Female, Italy, Menopause, Middle Aged, Multivariate Analysis, Quality of Life, Questionnaires, Socioeconomic Factors, Obstetrics and Gynecology, medicine.disease, Anxiety, sense organs, medicine.symptom, business
Abstract

Objectives: The aim of this cross-sectional study was to describe QoL in a large sample of women attending menopause centres and compare untreated postmenopausal women and matched HRT users by employing the Women's Health Questionnaire (WHQ) and two generic instruments, the SF-36 and the EQ-5D. Methods: Overall, 2906 women were recruited by 64 menopause centres throughout Italy, of whom 2160 filled in the questionnaire (1093 on HRT and 1067 not on HRT; response rate: 74%). Results: HRT users tended to be younger, healthier and with shorter menopause duration as opposed to non users, while no major socio-economic differences were present. At multivariate analysis, the presence of chronic diseases, low socio-economic status and living in Southern Italy represented the most important predictors of poor QoL. Furthermore, HRT users showed a lower probability of reporting problems in usual activities and pain/discomfort (EQ-5D), role limitations due to emotional problems (SF-36) and anxiety/fears (WHQ). HRT users also showed highly significant better outcomes in those areas that are more directly attributable to hormonal changes of mid age, namely vasomotor symptoms and sexual problems. Conclusions: Although QoL is mainly influenced by socio-economic and cultural factors, HRT has the potential for improving not only symptoms, but also more general aspects of physical and psychological well-being of symptomatic postmenopausal women.

Published
2002
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3. Factors associated with climacteric symptoms in women around menopause attending menopause clinics in Italy.

Author

Di Donato P, Giulini NA, Bacchi Modena A, Cicchetti G, Comitini G, Gentile G, Cristiani P, Careccia A, Esposito E, Gualdi F, Golinelli S, Bergamini E, Masellis G, Rastelli S, Gigli C, Elia A, Marchesoni D, Sticotti F, Del Frate G, Zompicchiatti C, Marino L, Costa MR, Pinto P, Dodero D, Storace A, Spinelli G, Quaranta S, Bossi CM, Ollago A, Omodei U, Vaccari M, Luerti M, Repetti F, Zandonini G, Raspagliesi F, Dolci F, Gambarino G, De Pasquale B, Polizzotti G, Borsellino G, Alpinelli P, Natale N, Colombo D, Belloni C, Viani A, Cecchini G, Vinci GW, Samaja BA, Pasinetti E, Penotti M, Ognissanti F, Pesando P, Malanetto C, Gallo M, Dolfin G, Tartaglino P, Mossotto D, Pistoni A, Tarani A, Rattazzi PD, Rossaro D, Campanella M, Arisi E, Gamper M, Salvatores D, Bocchin E, Stellin G, Meli G, Azzini V, Tirozzi F, Buoso G, Fraioli R, Marsoni V, Cetera C, Sposetti R, Candiotto E, Sposetti R, Candiotto E, Pignalosa R, Del Pup L, Bellati U, Angeloni C, Buonerba M, Garzarelli S, Santilli C, Mucci M, Di Nisio Q, Cappa F, Pierangeli I, Cordone A, Falasca L, Ferrante D, Cirese E, Todaro PA, Spagnuolo L, Lanzone A, Donadio C, Fabiani M, Baldaccini E, Votano S, Bellardini P, Favale W, Pietrobattista V, Massacesi L, Donini G, Del Savio F, Palombi L, Procaccioli P, Romani A, Romagnoli G, Genazzani AR, Gambacciani M, Scarselli G, Curiel P, De Leo V, Melani A, Levi D'Ancona V, Giarrè G, Di Gioia E, Ceccarelli P, Massi GB, Cosci S, Gacci G, Cascianini A, Donati Sarti C, Bircolotti S, Pupita P, Mincigrucci M, Spadafora A, Santeufemia G, Marongiu G, Lai GR, Lai R, Dessole S, D'Andrea SA, Coppola, Chiantera A, De Placido, Arienzo R, Pastore AR, Tamburrino A, Cardone A, Colacurci N, Izzo S, Tesauro R, Pascarella A, De Silvio MG, Di Prisco L, Lauda N, Sirimarco F, Agrimi C, Casarella G, Senatore G, Ronzini S, Ruccia G, De Carlo G, Pisaturo G, Carlomagno F, Fasolino A, Fiorillo F, Sorrentino R, Ercolano VB, Panariello S, Brun A, Tropea P, Stigliano CM, Amoroso A, Vadalà P, Coco A, Galati G, Barese G, Masciari G, Pirillo P, Gioffrè T, Mastrantonio P, Cardamone A, D'Angelo N, Valentino G, Barretta R, Ferraro G, Ferruccio C, Agostinelli D, Corrado G, Scopelliti A, Schonauer S, Trojano V, Bongiovanni F, Tinelli F, Poddi ER, Scarpello F, Colonna L, Fischetti G, Doria R, Trombetta G, Cocca EB, D'Amore A, Di Masi M, Liguori R, Dimaggio A, Laneve MR, Maolo MC, Gravina G, Nacci G, Nocera F, Lupo A, Giannola C, Graziano R, Mezzatesta M, Vegna G, Giannone G, Palumbo G, Cancellieri F, Mondo A, Cordopatri A, Carrubba M, Mazzola V, Cincotta L, D'Asta S, Bono A, Li Calsi L, Cavallaro Nigro S, Schilirò S, Repici A, Gullo D, Orlando A, Specchiale F, Papotto A, Angeloni, D'Andrea, Stigliano, Arienzo, Di Donato, Giulini, Gigli, Todaro, Marino, Luerti, Donini, Ferrante, Dolfin, Poddi, Santeufemia, Nocera, Melani, Arisi, Mincigrucci, Salvatores, Bocchin, Massacesi A, Chiantera A, De Aloysio P, Omodei U, Ognissanti F, Campagnoli C, Penotti M, Gambacciani A, Graziottin A, Baldi C, Colacurci N, Tonti GC, Parazzini F, Chatenoud L, and Donati Sarti C

Subjects
Adult, Age Factors, Aged, Body Mass Index, Climacteric psychology, Cross-Sectional Studies, Depression epidemiology, Diet, Educational Status, Female, Headache epidemiology, Hot Flashes epidemiology, Humans, Italy epidemiology, Logistic Models, Marital Status, Menopause psychology, Middle Aged, Reproductive History, Smoking, Ambulatory Care Facilities statistics & numerical data, Climacteric physiology, Menopause physiology
Abstract

Objective: To obtain data on correlates of climacteric symptoms in women around menopause attending menopause clinics in Italy., Methods: Since 1997 a large cross sectional study has been conducted on the characteristics of women around menopause attending a network of first level menopause outpatient's clinics in Italy. A total of 66,501 (mean age 54.4 years) women are considered in the present paper., Results: The odds ratios of moderate and severe hot flashes/night sweats were lower in more educated women and (for severe symptoms only) in women reporting regular physical activity. Depression, difficulty to sleep, forgetfulness and irritability tended to be less frequent in more educated women and (depression only) in women reporting regular physical activity. Parous women reported more frequently these symptoms., Conclusions: This large study confirms in Southern European population that low education, body mass index and low physical activity are associated with climacteric symptoms. Parous women are at greater risk of psychological symptoms.

Published
2005
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