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8 results on '"Freire-de-Lima, Leonardo"'

1. The Blessed Union of Glycobiology and Immunology: A Marriage That Worked

Author

dos Reis, Jhenifer Santos, primary, Diniz-Lima, Israel, additional, Santos, Marcos André Rodrigues da Costa, additional, Barcelos, Pedro Marçal, additional, da Costa, Kelli Monteiro, additional, Valente, Raphael do Carmo, additional, Chaves, Lorrane de Souza, additional, de Campos, Luma Petel, additional, dos Santos, Ariely Costa, additional, Correia de Lima, Rafaela Gomes, additional, Decote-Ricardo, Debora, additional, Morrot, Alexandre, additional, Previato, Jose Osvaldo, additional, Mendonça-Previato, Lucia, additional, Freire-de-Lima, Celio Geraldo, additional, Fonseca, Leonardo Marques da, additional, and Freire-de-Lima, Leonardo, additional

Published
2023
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2. Bittersweet Sugars: How Unusual Glycan Structures May Connect Epithelial-to-Mesenchymal Transition and Multidrug Resistance in Cancer.

Author

Fonseca, Leonardo Marques da, Diniz-Lima, Israel, da Costa Santos, Marcos André Rodrigues, Franklim, Tatiany Nunes, da Costa, Kelli Monteiro, Santos, Ariely Costa dos, Morrot, Alexandre, Decote-Ricardo, Debora, Valente, Raphael do Carmo, Freire-de-Lima, Celio Geraldo, dos Reis, Jhenifer Santos, and Freire-de-Lima, Leonardo

Subjects
GLYCAN structure, MULTIDRUG resistance, EPITHELIAL-mesenchymal transition, CARBOHYDRATE metabolism, SUGARS
Abstract

Cancer cells are characterized by metabolic reprogramming, which enables their survival in of-ten inhospitable conditions. A very well-documented example that has gained attraction in re-cent years and is already considered a hallmark of transformed cells is the reprogramming of carbohydrate metabolism. Such a feature, in association with the differential expression of en-zymes involved in the biosynthesis of glycoconjugates, generically known as glycosyltransfer-ases, contributes to the expression of structurally atypical glycans when compared to those ex-pressed in healthy tissues. The latest studies have demonstrated that glycophenotypic alterations are capable of modulating multifactorial events essential for the development and/or progres-sion of the disease. Herein, we will address the importance of glycobiology in modern medi-cine, focusing on the ability of unusual/truncated O-linked glycans to modulate two complex and essential phenomena for cancer progression: the acquisition of the multidrug resistance (MDR) phenotype and the activation of molecular pathways associated with the epithelial–mesenchymal transition (EMT) process, an event deeply linked with cancer metastasis. [ABSTRACT FROM AUTHOR]

Published
2023
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3. The Sweet Side of Fungal Infections: Structural Glycan Diversity and Its Importance for Pathogenic Adaptation

Author

Diniz-Lima, Israel, primary, da Fonseca, Leonardo Marques, additional, dos Reis, Jhenifer Santos, additional, Rodrigues da Costa Santos, Marcos André, additional, da Costa, Kelli Monteiro, additional, do Nascimento Santos, Carlos Antonio, additional, Barcelos, Pedro Marçal, additional, Guimarães-Pinto, Kamila, additional, Filardy, Alessandra Almeida, additional, Freire-de-Lima, Marco Edilson, additional, Decote-Ricardo, Debora, additional, Morrot, Alexandre, additional, Freire-de-Lima, Celio Geraldo, additional, and Freire-de-Lima, Leonardo, additional

Published
2022
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4. Glycobiology of Cancer: Sugar Drives the Show

Author

dos Reis, Jhenifer Santos, primary, Rodrigues da Costa Santos, Marcos André, additional, Mendonça, Daniella Pereira, additional, Martins do Nascimento, Stefani Ingrid, additional, Barcelos, Pedro Marçal, additional, Correia de Lima, Rafaela Gomes, additional, da Costa, Kelli Monteiro, additional, Freire-de-Lima, Celio Geraldo, additional, Morrot, Alexandre, additional, Previato, Jose Osvaldo, additional, Mendonça Previato, Lucia, additional, da Fonseca, Leonardo Marques, additional, and Freire-de-Lima, Leonardo, additional

Published
2022
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5. COVID-19 Infection and Neuropathological Features

Author

Freire-de-Lima, Leonardo, primary, Scovino, Aline Miranda, additional, Marques da Fonseca, Leonardo, additional, Barreto Menezes, Camilla Cristie, additional, Santos, Carlos Antonio do Nascimento, additional, Freire de Lima, Marco Edilson, additional, Decote-Ricardo, Debora, additional, Freire-de-Lima, Matheus, additional, da Costa, Kelli Monteiro, additional, dos Reis, Jhenifer Santos, additional, Rodrigues da Costa Santos, Marcos André, additional, Freire-de-Lima, Celio Geraldo, additional, and Morrot, Alexandre, additional

Published
2021
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6. Autoimmune Disorders & COVID-19

Author

Freire-de-Lima, Leonardo, primary, Scovino, Aline Miranda, additional, Barreto Menezes, Camilla Cristie, additional, Marques da Fonseca, Leonardo, additional, Santos dos Reis, Jhenifer, additional, Rodrigues da Costa Santos, Marcos André, additional, Monteiro da Costa, Kelli, additional, Antonio do Nascimento Santos, Carlos, additional, Freire-de-Lima, Celio Geraldo, additional, and Morrot, Alexandre, additional

Published
2021
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7. Glycobiology of Cancer: Sugar Drives the Show.

Author

Santos dos Reis, Jhenifer, Rodrigues da Costa Santos, Marcos André, Pereira Mendonça, Daniella, Martins do Nascimento, Stefani Ingrid, Marçal Barcelos, Pedro, Correia de Lima, Rafaela Gomes, Monteiro da Costa, Kelli, Geraldo Freire-de-Lima, Celio, Morrot, Alexandre, Osvaldo Previato, Jose, Mendonça Previato, Lucia, Marques da Fonseca, Leonardo, and Freire-de-Lima, Leonardo

Subjects
GLYCOMICS, CANCER treatment, GLYCOSYLATION, GLYCOSYLTRANSFERASES, IMMUNE response
Abstract

Cancer development and progression is associated with aberrant changes in cellular glycosylation. Cells expressing altered glycan-structures are recognized by cells of the immune system, favoring the induction of inhibitory immune processes which subsequently promote tumor growth and spreading. Here, we discuss about the importance of glycobiology in modern medicine, taking into account the impact of altered glycan structures expressed in cancer cells as potential glycobiomarkers of disease, as well as on cancer development and progression. [ABSTRACT FROM AUTHOR]

Published
2022
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8. Piperine Inhibits TGF-β Signaling Pathways and Disrupts EMT-Related Events in Human Lung Adenocarcinoma Cells

Author

Marques da Fonseca, Leonardo, primary, Jacques da Silva, Lucas Rodrigues, additional, Santos dos Reis, Jhenifer, additional, Rodrigues da Costa Santos, Marcos André, additional, de Sousa Chaves, Victoria, additional, Monteiro da Costa, Kelli, additional, Sa-Diniz, Julliana de Nazareth, additional, Freire de Lima, Celio Geraldo, additional, Morrot, Alexandre, additional, Nunes Franklim, Tatiany, additional, de Alcântara-Pinto, Douglas Chaves, additional, Freire de Lima, Marco Edilson, additional, Previato, Jose Osvaldo, additional, Mendonça-Previato, Lucia, additional, and Freire-de-Lima, Leonardo, additional

Published
2020
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