Search

Abstract: Despite repeated attempts to discover and develop novel effective therapeutic platforms, major hurdles remain to treat gastrointestinal cancers. The discovery of novel biomarkers is an important step in cancer treatment. MiRNAs have appeared as potent prognostic, diagnostic, and therapeutic biomarkers for a variety of cancers, including gastrointestinal cancers. They are quick, easy to detect, noninvasive, and inexpensive. MiR-28 is associated with a variety of gastrointestinal cancers, including esophageal, gastric, pancreatic, liver, and colorectal cancer. MiRNA expression is deregulated in cancer cells. Hence, the miRNAs expression patterns can be used to detect the subgroups of patients, the result is getting early detection and efficient treatment. miRNAs have an oncogenic or tumor-suppressor role based on tumor tissue, and cell types. It has been shown that dysregulation of miR-28 is involved in GI cancer occurrence, cancer cell growth and metastasis. Due to the limitations of single research and the lack of consensus results, in this review, we aim to summarize the current research advances in the diagnostic, prognostic, and therapeutic potential of circulating miR-28 levels in human gastrointestinal cancers.

MicroRNAs (miRNAs) are highly conserved non-coding RNAs involved in many physiological processes such as cell proliferation, inhibition, development of apoptosis, differentiation, suppression of tumorigenicity, and regulation of cell growth. The description of the alterations of miRNA expression patterns in cancers will be helpful in recognizing biomarkers for early detection and possible therapeutic intervention in the treatment of cancers. Recent studies have shown that miR-451 is broadly dysregulated in lung cancer and is a crucial agent in lung tumor progression. This review summarizes recent advances in the potential role of miR-451 in lung cancer diagnosis, prognosis, and treatment and provides an insight into the potential use of miR-451 for the development of advanced therapeutic methods in lung cancer.