1. Oxidative Damages to Eye Stem Cells, in Response to, Bright and Ultraviolet Light, Their Associated Mechanisms, and Salvage Pathways
- Author
-
Abdur Rashid Najwa, Sudheer Shenoy P, and Bipasha Bose
- Subjects
0106 biological sciences ,Cell signaling ,genetic structures ,Ultraviolet Rays ,Bioengineering ,Apoptosis ,Oxidative phosphorylation ,Eye ,01 natural sciences ,Applied Microbiology and Biotechnology ,Biochemistry ,Oxidative damage ,03 medical and health sciences ,Homeostatic mechanism ,010608 biotechnology ,Ultraviolet light ,Medicine ,Animals ,Humans ,Molecular Biology ,030304 developmental biology ,0303 health sciences ,business.industry ,Stem Cells ,Epithelial Cells ,eye diseases ,Cell biology ,Oxidative Stress ,sense organs ,Stem cell ,business ,Ocular surface ,Bright light ,Biotechnology ,Signal Transduction ,Stem Cell Transplantation - Abstract
The surface of the eye is continuously exposed to the harshness of the external environment. As a homeostatic mechanism for replenishing the worn off cells of the ocular surface, a balance is maintained via the role of ocular stem cells. However, under extreme conditions of harshness like exposure to bright and ultraviolet light, the ocular stem cells are unable to do the repair mechanisms resulting in severe impairment of vision and disturbances in the eye. This work reappraises the recent understandings of mechanisms of oxidative damages caused to the ocular stem cells by UV/bright light and their probable mitigation.
- Published
- 2018