1. Expression of breast cancer resistance protein in peripheral T cell subsets from HIV‑1‑infected patients with antiretroviral therapy
- Author
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Jiu‑Cong Zhang, Fang Xie, Zhi‑Yun Deng, Li Sun, Fang‑Xin Zhang, and Yong Wang
- Subjects
Oncology ,Adult ,CD4-Positive T-Lymphocytes ,Male ,Cancer Research ,medicine.medical_specialty ,T cell ,HIV Infections ,Drug resistance ,Biology ,CD8-Positive T-Lymphocytes ,medicine.disease_cause ,Biochemistry ,Peripheral blood mononuclear cell ,Internal medicine ,Antiretroviral Therapy, Highly Active ,Genetics ,medicine ,ATP Binding Cassette Transporter, Subfamily G, Member 2 ,Humans ,RNA, Messenger ,Molecular Biology ,Oncogene ,Cancer ,Middle Aged ,Viral Load ,medicine.disease ,Molecular medicine ,Neoplasm Proteins ,medicine.anatomical_structure ,Immunology ,HIV-1 ,Leukocytes, Mononuclear ,Molecular Medicine ,Reverse Transcriptase Inhibitors ,ATP-Binding Cassette Transporters ,Female ,Carcinogenesis ,CD8 - Abstract
The aim of the present study was to investigate the expression of breast cancer resistance protein (BCRP) in peripheral T cell subsets of human immunodeficiency virus 1 (HIV‑1)‑infected patients, and to analyze the association between the levels of BCRP expression and disease progression in HIV‑1 infection. Peripheral blood mononuclear cells (PBMCs) were obtained from HIV‑1‑infected patients (n=118), including 92 patients with antiretroviral therapy (ART) and 26 patients without a history of ART. Control samples from 30 healthy donors were also analyzed. The expression levels of BCRP in T cells were evaluated by flow cytometry. A high inter‑individual variability was observed in CD4+ and CD8+ T cells in the HIV‑1‑infected patients and healthy donors; however, the analyzed expression levels of BCRP were significantly higher in the HIV‑1‑infected group with ART than those in the group with no history of ART (P
- Published
- 2013