1. Integrative analysis of the contribution of mRNAs and long non-coding RNAs to the pathogenesis of asthma
- Author
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Xiaochuang Liu, Hui Jiang, Yanyan Zhang, Nan-nan Jiang, and Jia-Rong Gao
- Subjects
0301 basic medicine ,Cancer Research ,pathways ,Computational biology ,Biology ,Biochemistry ,Transcriptome ,03 medical and health sciences ,long non-coding RNAs ,0302 clinical medicine ,VEGF Signaling Pathway ,Genetics ,Humans ,RNA, Messenger ,KEGG ,Molecular Biology ,Gene ,Regulation of gene expression ,mechanisms ,Gene Expression Profiling ,Computational Biology ,RNA ,Molecular Sequence Annotation ,Articles ,asthma ,Gene expression profiling ,030104 developmental biology ,Gene Expression Regulation ,Oncology ,030220 oncology & carcinogenesis ,Molecular Medicine ,gene ontology ,RNA, Long Noncoding ,Disease Susceptibility ,Signal transduction - Abstract
Asthma, a common but poorly controlled disease, is one of the most serious health problems worldwide; however, the mechanisms underlying the development of asthma remain unknown. Long non‑coding RNAs (lncRNAs) and mRNAs serve important roles in the initiation and progression of various diseases. The present study aimed to investigate the role of differentially expressed lncRNAs and mRNAs associated with asthma. Differentially expressed lncRNAs and mRNAs were screened between the expression data of 62 patients with asthma and 43 healthy controls. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed to investigate the biological functions and pathways associated with the lncRNAs and mRNAs identified. Protein‑protein interaction (PPI) networks were subsequently generated. In addition, lncRNA‑mRNA weighted co‑expression networks were obtained. In total, 159 differentially expressed lncRNAs and 1,261 mRNAs were identified. GO and KEGG analyses revealed that differentially expressed mRNAs regulated asthma by participating in the 'vascular endothelial (VEGF) signaling pathway', 'oxidative phosphorylation', 'Fc e RI signaling pathway', 'amino sugar and nucleotide sugar metabolism', 'histidine metabolism', 'β‑alanine metabolism' and 'extracellular matrix‑receptor interaction' (P
- Published
- 2019