1. A Review on Preparation of Betulinic Acid and Its Biological Activities.
- Author
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Lou H, Li H, Zhang S, Lu H, and Chen Q
- Subjects
- Synthetic Biology methods, Biotransformation, Biosynthetic Pathways, Genetic Engineering, Antineoplastic Agents chemistry, Antineoplastic Agents metabolism, Antineoplastic Agents pharmacology, Anti-Infective Agents chemistry, Anti-Infective Agents metabolism, Anti-Infective Agents pharmacology, Antioxidants chemistry, Antioxidants metabolism, Antioxidants pharmacology, Humans, Animals, Fungi chemistry, Fungi metabolism, Betulinic Acid chemical synthesis, Betulinic Acid metabolism, Betulinic Acid pharmacology
- Abstract
Betulinic acid, a pentacyclic triterpene, is distributed in a variety of plants, such as birch, eucalyptus and plane trees. It shows a wide spectrum of biological and pharmacological properties, such as anti-inflammatory, antibacterial, antiviral, antidiabetic, antimalarial, anti-HIV and antitumor effects. Among them, the antitumor activity of betulinic acid has been extensively studied. However, obtaining betulinic acid from natural resources can no longer meet the needs of medicine and nutrition, so methods such as chemical synthesis and microbial biotransformation have also been used to prepare betulinic acid. At the same time, with the development of synthetic biology and genetic engineering, and the elucidation of the biosynthetic pathways of terpenoid, the biosynthesis of betulinic acid has also been extensively researched. This article reviews the preparation of betulinic acid and its pharmacological activities, in order to provide a reference for the research and utilization of betulinic acid.
- Published
- 2021
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