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The article focuses on a research paper published in the journal "Nature" which reveals sequencing of the tomato genome in the evolution of fruit size, texture, flavor and nutritional quality. The paper also reports genome sequences of cultivated tomato (Solanum lycopersicum) and its closest wild relative (Solanum pimpinellifolium) and reveals introgressions from wild relatives that prevent various agriculturally important traits.

The article presents a list that ranks researchers based on theirs papers and patent output along with a pie chart depicting areas of focus by percentage for research papers highlighted SciBX, a weekly publication that scans 50 select journals for articles of translational interest.

The article offers information regarding the trends in biotechnology literature in 2005. The number of output of biotech papers of the European Union outnumbered the U.S. scientists. South Korea was replaced by Belgium in the top 15 countries in terms of biotech paper output. It was also revealed that most researches deal in the field of metabolomics and nanotechnology.

The article presents data related to biotechnology research papers in the U.S. The US remains the most productive country in terms of biotech-related papers. But numbers of papers from the European Union surpassed the US last year (with Germany and the UK ahead of most EU countries); elsewhere, Korea, China and Japan also publish frequently. Some of the top cited papers, published in different journals, by field are: RNAi--Systematic functional analysis of the Caenorhabditis elegans genome using RNAi; Gene therapy--LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X2 and Nuclear transfer--Derivation of oocytes from mouse embryonic stem cells.

The article focuses on the significance of embryology in pointing out better ways of generating endodermal cells from embryonic stem (ES) cells. Researchers have made efforts to generate specialized cell types from ES cells wherein recapitulating in vitro the processes that produce definitive endoderm in the embryo would offer the surest route to differentiating human ES cells into insulin-producing hepatic cells. Significantly, the papers presented describe similar approaches to directing the differentiation of ES cells to definitive endoderm, with differences in the details of the methods and in the resulting cell populations.

This article presents summaries of studies related to nature biotechnology. A research study by Kobayashi et al published in a 2010 issue of "Cell" shows that it is possible to gestate rat-mice chimeras to term. A new paper by Ji et al from a 2010 issue of "Nature" is the first to map the methylome of a differentiation hierarchy that encompasses several stages of progressive cell-fate restriction. Rottmann et al in a 2010 issue of "Science" reported the use of cellular proliferation assays as antimalarials.

The article provides information on several biotechnology-related researches. A phase I clinical trial in eight individuals with mild Alzheimer disease appears to have slowed the decline of cognitive function. The treatment involved transplantation into the brain of autologous fibroblasts genetically modified to express nerve growth factor. Two papers in Science describe the use of synthetic gene regulatory cascades in Escherichia coli for determining what intrinsic and extrinsic factors contribute to gene expression fluctuations and how these fluctuations or "noise" are transmitted through gene cascades within single cells. The spread of West Nile virus, a zoonotic agent that can cause meningitis and encephalitis in the elderly and immunocompromised, is adding urgency to the search for new treatments to supplement human polyclonal antibodies.