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The article presents data related to biotechnology research papers in the U.S. The US remains the most productive country in terms of biotech-related papers. But numbers of papers from the European Union surpassed the US last year (with Germany and the UK ahead of most EU countries); elsewhere, Korea, China and Japan also publish frequently. Some of the top cited papers, published in different journals, by field are: RNAi--Systematic functional analysis of the Caenorhabditis elegans genome using RNAi; Gene therapy--LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X2 and Nuclear transfer--Derivation of oocytes from mouse embryonic stem cells.

The article discusses a study which shows that regulatory T cells (Tregs) can be used to prevent subsequent acute and chronic allograft rejection of tissues and solid transplants in a donor-specific manner in mice. In the paper, published in the journal "Nature Medicine," researchers also showed that Tregs can promote bone marrow chimerism. The researchers also presented evidence that directly alloreactive T cells has a significant role in mediating acute rejection while indirectly alloreactive T cells play a dominant role in mediating chronic rejection.

The article lists several research papers selected by the editors of the journal which includes topics related to immunogenicity of differentiated cells derived from pluripotent cells, generation of rejuvenated antigen-specific T cells and regeneration of human tumor antigen-specific T cells.