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1. An unusual two-strain cholera outbreak in Lebanon, 2022-2023: a genomic epidemiology study

Author

Abou Fayad, Antoine, Rafei, Rayane, Njamkepo, Elisabeth, Ezzeddine, Jana, Hussein, Hadi, Sinno, Solara, Gerges, Jose-Rita, Barada, Sara, Sleiman, Ahmad, Assi, Moubadda, Baakliny, Maryo, Hamedeh, Lama, Mahfouz, Rami, Dabboussi, Fouad, Feghali, Rita, Mohsen, Zeina, Rady, Alisar, Ghosn, Nada, Abiad, Firas, Abubakar, Abdinasir, Barakat, Amal, Wauquier, Nadia, Quilici, Marie-Laure, Hamze, Monzer, Weill, François-Xavier, and Matar, Ghassan M.

Published
2024
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3. An unusual two-strain cholera outbreak in Lebanon, 2022-2023: a genomic epidemiology study

Author

Antoine Abou Fayad, Rayane Rafei, Elisabeth Njamkepo, Jana Ezzeddine, Hadi Hussein, Solara Sinno, Jose-Rita Gerges, Sara Barada, Ahmad Sleiman, Moubadda Assi, Maryo Baakliny, Lama Hamedeh, Rami Mahfouz, Fouad Dabboussi, Rita Feghali, Zeina Mohsen, Alisar Rady, Nada Ghosn, Firas Abiad, Abdinasir Abubakar, Amal Barakat, Nadia Wauquier, Marie-Laure Quilici, Monzer Hamze, François-Xavier Weill, and Ghassan M. Matar

Subjects
Science
Abstract

Abstract Cholera is a life-threatening gastrointestinal infection caused by a toxigenic bacterium, Vibrio cholerae. After a lull of almost 30 years, a first case of cholera was detected in Lebanon in October 2022. The outbreak lasted three months, with 8007 suspected cases (671 laboratory-confirmed) and 23 deaths. In this study, we use phenotypic methods and microbial genomics to study 34 clinical and environmental Vibrio cholerae isolates collected throughout this outbreak. All isolates are identified as V. cholerae O1, serotype Ogawa strains from wave 3 of the seventh pandemic El Tor (7PET) lineage. Phylogenomic analysis unexpectedly reveals the presence of two different strains of the seventh pandemic El Tor (7PET) lineage. The dominant strain has a narrow antibiotic resistance profile and is phylogenetically related to South Asian V. cholerae isolates and derived African isolates from the AFR15 sublineage. The second strain is geographically restricted and extensively drug-resistant. It belongs to the AFR13 sublineage and clusters with V. cholerae isolates collected in Yemen. In conclusion, the 2022-2023 Lebanese cholera outbreak is caused by the simultaneous introduction of two different 7PET strains. Genomic surveillance with cross-border collaboration is therefore crucial for the identification of new introductions and routes of circulation of cholera, improving our understanding of cholera epidemiology.

Published
2024
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4. A druggable conformational switch in the c-MYC transactivation domain

Author

Dilraj Lama, Thibault Vosselman, Cagla Sahin, Judit Liaño-Pons, Carmine P. Cerrato, Lennart Nilsson, Kaare Teilum, David P. Lane, Michael Landreh, and Marie Arsenian Henriksson

Subjects
Science
Abstract

Abstract The c-MYC oncogene is activated in over 70% of all human cancers. The intrinsic disorder of the c-MYC transcription factor facilitates molecular interactions that regulate numerous biological pathways, but severely limits efforts to target its function for cancer therapy. Here, we use a reductionist strategy to characterize the dynamic and structural heterogeneity of the c-MYC protein. Using probe-based Molecular Dynamics (MD) simulations and machine learning, we identify a conformational switch in the c-MYC amino-terminal transactivation domain (termed coreMYC) that cycles between a closed, inactive, and an open, active conformation. Using the polyphenol epigallocatechin gallate (EGCG) to modulate the conformational landscape of coreMYC, we show through biophysical and cellular assays that the induction of a closed conformation impedes its interactions with the transformation/transcription domain-associated protein (TRRAP) and the TATA-box binding protein (TBP) which are essential for the transcriptional and oncogenic activities of c-MYC. Together, these findings provide insights into structure-activity relationships of c-MYC, which open avenues towards the development of shape-shifting compounds to target c-MYC as well as other disordered transcription factors for cancer treatment.

Published
2024
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9. Clinical utility of polygenic scores for cardiometabolic disease in Arabs

Author

Injeong Shim, Hiroyuki Kuwahara, NingNing Chen, Mais O. Hashem, Lama AlAbdi, Mohamed Abouelhoda, Hong-Hee Won, Pradeep Natarajan, Patrick T. Ellinor, Amit V. Khera, Xin Gao, Fowzan S. Alkuraya, and Akl C. Fahed

Subjects
Science
Abstract

Abstract Arabs account for 5% of the world population and have a high burden of cardiometabolic disease, yet clinical utility of polygenic risk prediction in Arabs remains understudied. Among 5399 Arab patients, we optimize polygenic scores for 10 cardiometabolic traits, achieving a performance that is better than published scores and on par with performance in European-ancestry individuals. Odds ratio per standard deviation (OR per SD) for a type 2 diabetes score was 1.83 (95% CI 1.74–1.92), and each SD of body mass index (BMI) score was associated with 1.18 kg/m2 difference in BMI. Polygenic scores associated with disease independent of conventional risk factors, and also associated with disease severity—OR per SD for coronary artery disease (CAD) was 1.78 (95% CI 1.66–1.90) for three-vessel CAD and 1.41 (95% CI 1.29–1.53) for one-vessel CAD. We propose a pragmatic framework leveraging public data as one way to advance equitable clinical implementation of polygenic scores in non-European populations.

Published
2023
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10. Diagnostic implications of pitfalls in causal variant identification based on 4577 molecularly characterized families

Author

Lama AlAbdi, Sateesh Maddirevula, Hanan E. Shamseldin, Ebtissal Khouj, Rana Helaby, Halima Hamid, Aisha Almulhim, Mais O. Hashem, Firdous Abdulwahab, Omar Abouyousef, Mashael Alqahtani, Norah Altuwaijri, Amal Jaafar, Tarfa Alshidi, Fatema Alzahrani, Mendeliome Group, and Fowzan S. Alkuraya

Subjects
Science
Abstract

Abstract Despite large sequencing and data sharing efforts, previously characterized pathogenic variants only account for a fraction of Mendelian disease patients, which highlights the need for accurate identification and interpretation of novel variants. In a large Mendelian cohort of 4577 molecularly characterized families, numerous scenarios in which variant identification and interpretation can be challenging are encountered. We describe categories of challenges that cover the phenotype (e.g. novel allelic disorders), pedigree structure (e.g. imprinting disorders masquerading as autosomal recessive phenotypes), positional mapping (e.g. double recombination events abrogating candidate autozygous intervals), gene (e.g. novel gene-disease assertion) and variant (e.g. complex compound inheritance). Overall, we estimate a probability of 34.3% for encountering at least one of these challenges. Importantly, our data show that by only addressing non-sequencing-based challenges, around 71% increase in the diagnostic yield can be expected. Indeed, by applying these lessons to a cohort of 314 cases with negative clinical exome or genome reports, we could identify the likely causal variant in 54.5%. Our work highlights the need to have a thorough approach to undiagnosed diseases by considering a wide range of challenges rather than a narrow focus on sequencing technologies. It is hoped that by sharing this experience, the yield of undiagnosed disease programs globally can be improved.

Published
2023
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11. A randomized clinical trial assessing the effect of automated medication-targeted alerts on acute kidney injury outcomes

Author

F. Perry Wilson, Yu Yamamoto, Melissa Martin, Claudia Coronel-Moreno, Fan Li, Chao Cheng, Abinet Aklilu, Lama Ghazi, Jason H. Greenberg, Stephen Latham, Hannah Melchinger, Sherry G. Mansour, Dennis G. Moledina, Chirag R. Parikh, Caitlin Partridge, Jeffrey M. Testani, and Ugochukwu Ugwuowo

Subjects
Science
Abstract

Abstract Acute kidney injury is common among hospitalized individuals, particularly those exposed to certain medications, and is associated with substantial morbidity and mortality. In a pragmatic, open-label, National Institutes of Health-funded, parallel group randomized controlled trial (clinicaltrials.gov NCT02771977), we investigate whether an automated clinical decision support system affects discontinuation rates of potentially nephrotoxic medications and improves outcomes in patients with AKI. Participants included 5060 hospitalized adults with AKI and an active order for any of three classes of medications of interest: non-steroidal anti-inflammatory drugs, renin-angiotensin-aldosterone system inhibitors, or proton pump inhibitors. Within 24 hours of randomization, a medication of interest was discontinued in 61.1% of the alert group versus 55.9% of the usual care group (relative risk 1.08, 1.04 – 1.14, p = 0.0003). The primary outcome – a composite of progression of acute kidney injury, dialysis, or death within 14 days - occurred in 585 (23.1%) of individuals in the alert group and 639 (25.3%) of patients in the usual care group (RR 0.92, 0.83 – 1.01, p = 0.09). Trial Registration Clinicaltrials.gov NCT02771977.

Published
2023
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12. A-MYB and BRDT-dependent RNA Polymerase II pause release orchestrates transcriptional regulation in mammalian meiosis

Author

Adriana K. Alexander, Edward J. Rice, Jelena Lujic, Leah E. Simon, Stephanie Tanis, Gilad Barshad, Lina Zhu, Jyoti Lama, Paula E. Cohen, and Charles G. Danko

Subjects
Science
Abstract

During spermatogenic meiosis, chromatin changes due to transcription, homologous recombination, and chromosome synapsis must be coordinated. Here they show that A-MYC and BRDT regulate release of paused RNA PolII to induce a transcriptional burst during pachytene of prophase I.

Published
2023
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13. Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex

Author

Yuri Frosi, Yen-Chu Lin, Jiang Shimin, Siti Radhiah Ramlan, Kelly Hew, Alf Henrik Engman, Anil Pillai, Kit Yeung, Yue Xiang Cheng, Tobias Cornvik, Par Nordlund, Megan Goh, Dilraj Lama, Zachary P. Gates, Chandra S. Verma, Dawn Thean, David P. Lane, Ignacio Asial, and Christopher J. Brown

Subjects
Science
Abstract

Approaches have been devised to increase the discovery rate of intrabodies but often these yield results that aren’t functional in cells. Here the authors engineer and optimise an autonomous and disulphide-free human VH domain for intracellular expression, and they identify several VH domain binders against eIF4E.

Published
2022
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14. Environmentally adaptive MOF-based device enables continuous self-optimizing atmospheric water harvesting

Author

Husam A. Almassad, Rada I. Abaza, Lama Siwwan, Bassem Al-Maythalony, and Kyle E. Cordova

Subjects
Science
Abstract

Atmospheric water harvesting by MOF-based devices is critically dependent on weather conditions. Here, the authors report a MOF-based adaptive water harvesting system capable of adapting its cycles to temperature and relative humidity fluctuations throughout the day, continuously optimizing water production.

Published
2022
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17. National identity predicts public health support during a global pandemic

Author

Van Bavel, Jay J., Cichocka, Aleksandra, Capraro, Valerio, Sjåstad, Hallgeir, Nezlek, John B., Pavlović, Tomislav, Alfano, Mark, Gelfand, Michele J., Azevedo, Flavio, Birtel, Michèle D., Cislak, Aleksandra, Lockwood, Patricia L., Ross, Robert Malcolm, Abts, Koen, Agadullina, Elena, Aruta, John Jamir Benzon, Besharati, Sahba Nomvula, Bor, Alexander, Choma, Becky L., Crabtree, Charles David, Cunningham, William A., De, Koustav, Ejaz, Waqas, Elbaek, Christian T., Findor, Andrej, Flichtentrei, Daniel, Franc, Renata, Gjoneska, Biljana, Gruber, June, Gualda, Estrella, Horiuchi, Yusaku, Huynh, Toan Luu Duc, Ibanez, Augustin, Imran, Mostak Ahamed, Israelashvili, Jacob, Jasko, Katarzyna, Kantorowicz, Jaroslaw, Kantorowicz-Reznichenko, Elena, Krouwel, André, Laakasuo, Michael, Lamm, Claus, Leygue, Caroline, Lin, Ming-Jen, Mansoor, Mohammad Sabbir, Marie, Antoine, Mayiwar, Lewend, Mazepus, Honorata, McHugh, Cillian, Minda, John Paul, Mitkidis, Panagiotis, Olsson, Andreas, Otterbring, Tobias, Packer, Dominic J., Perry, Anat, Petersen, Michael Bang, Puthillam, Arathy, Riaño-Moreno, Julián C., Rothmund, Tobias, Santamaría-García, Hernando, Schmid, Petra C., Stoyanov, Drozdstoy, Tewari, Shruti, Todosijević, Bojan, Tsakiris, Manos, Tung, Hans H., Umbreș, Radu G., Vanags, Edmunds, Vlasceanu, Madalina, Vonasch, Andrew, Yucel, Meltem, Zhang, Yucheng, Abad, Mohcine, Adler, Eli, Akrawi, Narin, Mdarhri, Hamza Alaoui, Amara, Hanane, Amodio, David M., Antazo, Benedict G., Apps, Matthew, Ay, F. Ceren, Ba, Mouhamadou Hady, Barbosa, Sergio, Bastian, Brock, Berg, Anton, Bernal-Zárate, Maria P., Bernstein, Michael, Białek, Michał, Bilancini, Ennio, Bogatyreva, Natalia, Boncinelli, Leonardo, Booth, Jonathan E., Borau, Sylvie, Buchel, Ondrej, Cameron, C. Daryl, Carvalho, Chrissie F., Celadin, Tatiana, Cerami, Chiara, Chalise, Hom Nath, Cheng, Xiaojun, Cian, Luca, Cockcroft, Kate, Conway, Jane, Córdoba-Delgado, Mateo Andres, Crespi, Chiara, Crouzevialle, Marie, Cutler, Jo, Cypryańska, Marzena, Dabrowska, Justyna, Daniels, Michael A., Davis, Victoria H., Dayley, Pamala N., Delouvee, Sylvain, Denkovski, Ognjan, Dezecache, Guillaume, Dhaliwal, Nathan A., Diato, Alelie B., Di Paolo, Roberto, Drosinou, Marianna, Dulleck, Uwe, Ekmanis, Jānis, Ertan, Arhan S., Etienne, Tom W., Farhana, Hapsa Hossain, Farkhari, Fahima, Farmer, Harry, Fenwick, Ali, Fidanovski, Kristijan, Flew, Terry, Fraser, Shona, Frempong, Raymond Boadi, Fugelsang, Jonathan A., Gale, Jessica, Garcia-Navarro, E. Begoña, Garladinne, Prasad, Ghajjou, Oussama, Gkinopoulos, Theofilos, Gray, Kurt, Griffin, Siobhán M., Gronfeldt, Bjarki, Gümren, Mert, Gurung, Ranju Lama, Halperin, Eran, Harris, Elizabeth, Herzon, Volo, Hruška, Matej, Huang, Guanxiong, Hudecek, Matthias F. C., Isler, Ozan, Jangard, Simon, Jørgensen, Frederik J., Kachanoff, Frank, Kahn, John, Dangol, Apsara Katuwal, Keudel, Oleksandra, Koppel, Lina, Koverola, Mika, Kubin, Emily, Kunnari, Anton, Kutiyski, Yordan, Laguna, Oscar, Leota, Josh, Lermer, Eva, Levy, Jonathan, Levy, Neil, Li, Chunyun, Long, Elizabeth U., Longoni, Chiara, Maglić, Marina, McCashin, Darragh, Metcalf, Alexander L., Mikloušić, Igor, El Mimouni, Soulaimane, Miura, Asako, Molina-Paredes, Juliana, Monroy-Fonseca, César, Morales-Marente, Elena, Moreau, David, Muda, Rafał, Myer, Annalisa, Nash, Kyle, Nesh-Nash, Tarik, Nitschke, Jonas P., Nurse, Matthew S., Ohtsubo, Yohsuke, Oldemburgo de Mello, Victoria, O’Madagain, Cathal, Onderco, Michal, Palacios-Galvez, M. Soledad, Palomäki, Jussi, Pan, Yafeng, Papp, Zsófia, Pärnamets, Philip, Paruzel-Czachura, Mariola, Pavlović, Zoran, Payán-Gómez, César, Perander, Silva, Pitman, Michael Mark, Prasad, Rajib, Pyrkosz-Pacyna, Joanna, Rathje, Steve, Raza, Ali, Rêgo, Gabriel G., Rhee, Kasey, Robertson, Claire E., Rodríguez-Pascual, Iván, Saikkonen, Teemu, Salvador-Ginez, Octavio, Sampaio, Waldir M., Santi, Gaia C., Santiago-Tovar, Natalia, Savage, David, Scheffer, Julian A., Schönegger, Philipp, Schultner, David T., Schutte, Enid M., Scott, Andy, Sharma, Madhavi, Sharma, Pujan, Skali, Ahmed, Stadelmann, David, Stafford, Clara Alexandra, Stanojević, Dragan, Stefaniak, Anna, Sternisko, Anni, Stoica, Augustin, Stoyanova, Kristina K., Strickland, Brent, Sundvall, Jukka, Thomas, Jeffrey P., Tinghög, Gustav, Torgler, Benno, Traast, Iris J., Tucciarelli, Raffaele, Tyrala, Michael, Ungson, Nick D., Uysal, Mete S., Van Lange, Paul A. M., van Prooijen, Jan-Willem, van Rooy, Dirk, Västfjäll, Daniel, Verkoeijen, Peter, Vieira, Joana B., von Sikorski, Christian, Walker, Alexander Cameron, Watermeyer, Jennifer, Wetter, Erik, Whillans, Ashley, Willardt, Robin, Wohl, Michael J. A., Wójcik, Adrian Dominik, Wu, Kaidi, Yamada, Yuki, Yilmaz, Onurcan, Yogeeswaran, Kumar, Ziemer, Carolin-Theresa, Zwaan, Rolf A., and Boggio, Paulo S.

Published
2022
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18. Author Correction: National identity predicts public health support during a global pandemic

Author

Van Bavel, Jay J., Cichocka, Aleksandra, Capraro, Valerio, Sjåstad, Hallgeir, Nezlek, John B., Pavlović, Tomislav, Alfano, Mark, Gelfand, Michele J., Azevedo, Flavio, Birtel, Michèle D., Cislak, Aleksandra, Lockwood, Patricia L., Ross, Robert Malcolm, Abts, Koen, Agadullina, Elena, Aruta, John Jamir Benzon, Besharati, Sahba Nomvula, Bor, Alexander, Choma, Becky L., Crabtree, Charles David, Cunningham, William A., De, Koustav, Ejaz, Waqas, Elbaek, Christian T., Findor, Andrej, Flichtentrei, Daniel, Franc, Renata, Gjoneska, Biljana, Gruber, June, Gualda, Estrella, Horiuchi, Yusaku, Huynh, Toan Luu Duc, Ibanez, Agustin, Imran, Mostak Ahamed, Israelashvili, Jacob, Jasko, Katarzyna, Kantorowicz, Jaroslaw, Kantorowicz-Reznichenko, Elena, Krouwel, André, Laakasuo, Michael, Lamm, Claus, Leygue, Caroline, Lin, Ming-Jen, Mansoor, Mohammad Sabbir, Marie, Antoine, Mayiwar, Lewend, Mazepus, Honorata, McHugh, Cillian, Minda, John Paul, Mitkidis, Panagiotis, Olsson, Andreas, Otterbring, Tobias, Packer, Dominic J., Perry, Anat, Petersen, Michael Bang, Puthillam, Arathy, Riaño-Moreno, Julián C., Rothmund, Tobias, Santamaría-García, Hernando, Schmid, Petra C., Stoyanov, Drozdstoy, Tewari, Shruti, Todosijević, Bojan, Tsakiris, Manos, Tung, Hans H., Umbreș, Radu G., Vanags, Edmunds, Vlasceanu, Madalina, Vonasch, Andrew, Yucel, Meltem, Zhang, Yucheng, Abad, Mohcine, Adler, Eli, Akrawi, Narin, Mdarhri, Hamza Alaoui, Amara, Hanane, Amodio, David M., Antazo, Benedict G., Apps, Matthew, Ay, F. Ceren, Ba, Mouhamadou Hady, Barbosa, Sergio, Bastian, Brock, Berg, Anton, Bernal-Zárate, Maria P., Bernstein, Michael, Białek, Michał, Bilancini, Ennio, Bogatyreva, Natalia, Boncinelli, Leonardo, Booth, Jonathan E., Borau, Sylvie, Buchel, Ondrej, Cameron, C. Daryl, Carvalho, Chrissie F., Celadin, Tatiana, Cerami, Chiara, Chalise, Hom Nath, Cheng, Xiaojun, Cian, Luca, Cockcroft, Kate, Conway, Jane, Córdoba-Delgado, Mateo Andres, Crespi, Chiara, Crouzevialle, Marie, Cutler, Jo, Cypryańska, Marzena, Dabrowska, Justyna, Daniels, Michael A., Davis, Victoria H., Dayley, Pamala N., Delouvee, Sylvain, Denkovski, Ognjan, Dezecache, Guillaume, Dhaliwal, Nathan A., Diato, Alelie B., Di Paolo, Roberto, Drosinou, Marianna, Dulleck, Uwe, Ekmanis, Jānis, Ertan, Arhan S., Etienne, Tom W., Farhana, Hapsa Hossain, Farkhari, Fahima, Farmer, Harry, Fenwick, Ali, Fidanovski, Kristijan, Flew, Terry, Fraser, Shona, Frempong, Raymond Boadi, Fugelsang, Jonathan A., Gale, Jessica, Garcia-Navarro, E. Begoña, Garladinne, Prasad, Ghajjou, Oussama, Gkinopoulos, Theofilos, Gray, Kurt, Griffin, Siobhán M., Gronfeldt, Bjarki, Gümren, Mert, Gurung, Ranju Lama, Halperin, Eran, Harris, Elizabeth, Herzon, Volo, Hruška, Matej, Huang, Guanxiong, Hudecek, Matthias F. C., Isler, Ozan, Jangard, Simon, Jørgensen, Frederik J., Kachanoff, Frank, Kahn, John, Dangol, Apsara Katuwal, Keudel, Oleksandra, Koppel, Lina, Koverola, Mika, Kubin, Emily, Kunnari, Anton, Kutiyski, Yordan, Laguna, Oscar, Leota, Josh, Lermer, Eva, Levy, Jonathan, Levy, Neil, Li, Chunyun, Long, Elizabeth U., Longoni, Chiara, Maglić, Marina, McCashin, Darragh, Metcalf, Alexander L., Mikloušić, Igor, El Mimouni, Soulaimane, Miura, Asako, Molina-Paredes, Juliana, Monroy-Fonseca, César, Morales-Marente, Elena, Moreau, David, Muda, Rafał, Myer, Annalisa, Nash, Kyle, Nesh-Nash, Tarik, Nitschke, Jonas P., Nurse, Matthew S., Ohtsubo, Yohsuke, Oldemburgo de Mello, Victoria, O’Madagain, Cathal, Onderco, Michal, Palacios-Galvez, M. Soledad, Palomäki, Jussi, Pan, Yafeng, Papp, Zsófia, Pärnamets, Philip, Paruzel-Czachura, Mariola, Pavlović, Zoran, Payán-Gómez, César, Perander, Silva, Pitman, Michael Mark, Prasad, Rajib, Pyrkosz-Pacyna, Joanna, Rathje, Steve, Raza, Ali, Rêgo, Gabriel G., Rhee, Kasey, Robertson, Claire E., Rodríguez-Pascual, Iván, Saikkonen, Teemu, Salvador-Ginez, Octavio, Sampaio, Waldir M., Santi, Gaia C., Santiago-Tovar, Natalia, Savage, David, Scheffer, Julian A., Schönegger, Philipp, Schultner, David T., Schutte, Enid M., Scott, Andy, Sharma, Madhavi, Sharma, Pujan, Skali, Ahmed, Stadelmann, David, Stafford, Clara Alexandra, Stanojević, Dragan, Stefaniak, Anna, Sternisko, Anni, Stoica, Augustin, Stoyanova, Kristina K., Strickland, Brent, Sundvall, Jukka, Thomas, Jeffrey P., Tinghög, Gustav, Torgler, Benno, Traast, Iris J., Tucciarelli, Raffaele, Tyrala, Michael, Ungson, Nick D., Uysal, Mete S., Van Lange, Paul A. M., van Prooijen, Jan-Willem, van Rooy, Dirk, Västfjäll, Daniel, Verkoeijen, Peter, Vieira, Joana B., von Sikorski, Christian, Walker, Alexander Cameron, Watermeyer, Jennifer, Wetter, Erik, Whillans, Ashley, Willardt, Robin, Wohl, Michael J. A., Wójcik, Adrian Dominik, Wu, Kaidi, Yamada, Yuki, Yilmaz, Onurcan, Yogeeswaran, Kumar, Ziemer, Carolin-Theresa, Zwaan, Rolf A., and Boggio, Paulo S.

Published
2022
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19. National identity predicts public health support during a global pandemic

Author

Jay J. Van Bavel, Aleksandra Cichocka, Valerio Capraro, Hallgeir Sjåstad, John B. Nezlek, Tomislav Pavlović, Mark Alfano, Michele J. Gelfand, Flavio Azevedo, Michèle D. Birtel, Aleksandra Cislak, Patricia L. Lockwood, Robert Malcolm Ross, Koen Abts, Elena Agadullina, John Jamir Benzon Aruta, Sahba Nomvula Besharati, Alexander Bor, Becky L. Choma, Charles David Crabtree, William A. Cunningham, Koustav De, Waqas Ejaz, Christian T. Elbaek, Andrej Findor, Daniel Flichtentrei, Renata Franc, Biljana Gjoneska, June Gruber, Estrella Gualda, Yusaku Horiuchi, Toan Luu Duc Huynh, Augustin Ibanez, Mostak Ahamed Imran, Jacob Israelashvili, Katarzyna Jasko, Jaroslaw Kantorowicz, Elena Kantorowicz-Reznichenko, André Krouwel, Michael Laakasuo, Claus Lamm, Caroline Leygue, Ming-Jen Lin, Mohammad Sabbir Mansoor, Antoine Marie, Lewend Mayiwar, Honorata Mazepus, Cillian McHugh, John Paul Minda, Panagiotis Mitkidis, Andreas Olsson, Tobias Otterbring, Dominic J. Packer, Anat Perry, Michael Bang Petersen, Arathy Puthillam, Julián C. Riaño-Moreno, Tobias Rothmund, Hernando Santamaría-García, Petra C. Schmid, Drozdstoy Stoyanov, Shruti Tewari, Bojan Todosijević, Manos Tsakiris, Hans H. Tung, Radu G. Umbreș, Edmunds Vanags, Madalina Vlasceanu, Andrew Vonasch, Meltem Yucel, Yucheng Zhang, Mohcine Abad, Eli Adler, Narin Akrawi, Hamza Alaoui Mdarhri, Hanane Amara, David M. Amodio, Benedict G. Antazo, Matthew Apps, F. Ceren Ay, Mouhamadou Hady Ba, Sergio Barbosa, Brock Bastian, Anton Berg, Maria P. Bernal-Zárate, Michael Bernstein, Michał Białek, Ennio Bilancini, Natalia Bogatyreva, Leonardo Boncinelli, Jonathan E. Booth, Sylvie Borau, Ondrej Buchel, C. Daryl Cameron, Chrissie F. Carvalho, Tatiana Celadin, Chiara Cerami, Hom Nath Chalise, Xiaojun Cheng, Luca Cian, Kate Cockcroft, Jane Conway, Mateo Andres Córdoba-Delgado, Chiara Crespi, Marie Crouzevialle, Jo Cutler, Marzena Cypryańska, Justyna Dabrowska, Michael A. Daniels, Victoria H. Davis, Pamala N. Dayley, Sylvain Delouvee, Ognjan Denkovski, Guillaume Dezecache, Nathan A. Dhaliwal, Alelie B. Diato, Roberto Di Paolo, Marianna Drosinou, Uwe Dulleck, Jānis Ekmanis, Arhan S. Ertan, Tom W. Etienne, Hapsa Hossain Farhana, Fahima Farkhari, Harry Farmer, Ali Fenwick, Kristijan Fidanovski, Terry Flew, Shona Fraser, Raymond Boadi Frempong, Jonathan A. Fugelsang, Jessica Gale, E. Begoña Garcia-Navarro, Prasad Garladinne, Oussama Ghajjou, Theofilos Gkinopoulos, Kurt Gray, Siobhán M. Griffin, Bjarki Gronfeldt, Mert Gümren, Ranju Lama Gurung, Eran Halperin, Elizabeth Harris, Volo Herzon, Matej Hruška, Guanxiong Huang, Matthias F. C. Hudecek, Ozan Isler, Simon Jangard, Frederik J. Jørgensen, Frank Kachanoff, John Kahn, Apsara Katuwal Dangol, Oleksandra Keudel, Lina Koppel, Mika Koverola, Emily Kubin, Anton Kunnari, Yordan Kutiyski, Oscar Laguna, Josh Leota, Eva Lermer, Jonathan Levy, Neil Levy, Chunyun Li, Elizabeth U. Long, Chiara Longoni, Marina Maglić, Darragh McCashin, Alexander L. Metcalf, Igor Mikloušić, Soulaimane El Mimouni, Asako Miura, Juliana Molina-Paredes, César Monroy-Fonseca, Elena Morales-Marente, David Moreau, Rafał Muda, Annalisa Myer, Kyle Nash, Tarik Nesh-Nash, Jonas P. Nitschke, Matthew S. Nurse, Yohsuke Ohtsubo, Victoria Oldemburgo de Mello, Cathal O’Madagain, Michal Onderco, M. Soledad Palacios-Galvez, Jussi Palomäki, Yafeng Pan, Zsófia Papp, Philip Pärnamets, Mariola Paruzel-Czachura, Zoran Pavlović, César Payán-Gómez, Silva Perander, Michael Mark Pitman, Rajib Prasad, Joanna Pyrkosz-Pacyna, Steve Rathje, Ali Raza, Gabriel G. Rêgo, Kasey Rhee, Claire E. Robertson, Iván Rodríguez-Pascual, Teemu Saikkonen, Octavio Salvador-Ginez, Waldir M. Sampaio, Gaia C. Santi, Natalia Santiago-Tovar, David Savage, Julian A. Scheffer, Philipp Schönegger, David T. Schultner, Enid M. Schutte, Andy Scott, Madhavi Sharma, Pujan Sharma, Ahmed Skali, David Stadelmann, Clara Alexandra Stafford, Dragan Stanojević, Anna Stefaniak, Anni Sternisko, Augustin Stoica, Kristina K. Stoyanova, Brent Strickland, Jukka Sundvall, Jeffrey P. Thomas, Gustav Tinghög, Benno Torgler, Iris J. Traast, Raffaele Tucciarelli, Michael Tyrala, Nick D. Ungson, Mete S. Uysal, Paul A. M. Van Lange, Jan-Willem van Prooijen, Dirk van Rooy, Daniel Västfjäll, Peter Verkoeijen, Joana B. Vieira, Christian von Sikorski, Alexander Cameron Walker, Jennifer Watermeyer, Erik Wetter, Ashley Whillans, Robin Willardt, Michael J. A. Wohl, Adrian Dominik Wójcik, Kaidi Wu, Yuki Yamada, Onurcan Yilmaz, Kumar Yogeeswaran, Carolin-Theresa Ziemer, Rolf A. Zwaan, and Paulo S. Boggio

Subjects
Science
Abstract

Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

Published
2022
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20. DNase II mediates a parthanatos-like developmental cell death pathway in Drosophila primordial germ cells

Author

Lama Tarayrah-Ibraheim, Elital Chass Maurice, Guy Hadary, Sharon Ben-Hur, Alina Kolpakova, Tslil Braun, Yoav Peleg, Keren Yacobi-Sharon, and Eli Arama

Subjects
Science
Abstract

Caspase independent alternative cell death (ACD) pathways exist, but have been largely investigated under non-physiological conditions. Here, the authors show that Drosophila primordial germ cells normally elicit DNase II-dependent DNA damage, triggering a parthanatos-like ACD pathway.

Published
2021
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22. Author Correction: National identity predicts public health support during a global pandemic

Author

Jay J. Van Bavel, Aleksandra Cichocka, Valerio Capraro, Hallgeir Sjåstad, John B. Nezlek, Tomislav Pavlović, Mark Alfano, Michele J. Gelfand, Flavio Azevedo, Michèle D. Birtel, Aleksandra Cislak, Patricia L. Lockwood, Robert Malcolm Ross, Koen Abts, Elena Agadullina, John Jamir Benzon Aruta, Sahba Nomvula Besharati, Alexander Bor, Becky L. Choma, Charles David Crabtree, William A. Cunningham, Koustav De, Waqas Ejaz, Christian T. Elbaek, Andrej Findor, Daniel Flichtentrei, Renata Franc, Biljana Gjoneska, June Gruber, Estrella Gualda, Yusaku Horiuchi, Toan Luu Duc Huynh, Agustin Ibanez, Mostak Ahamed Imran, Jacob Israelashvili, Katarzyna Jasko, Jaroslaw Kantorowicz, Elena Kantorowicz-Reznichenko, André Krouwel, Michael Laakasuo, Claus Lamm, Caroline Leygue, Ming-Jen Lin, Mohammad Sabbir Mansoor, Antoine Marie, Lewend Mayiwar, Honorata Mazepus, Cillian McHugh, John Paul Minda, Panagiotis Mitkidis, Andreas Olsson, Tobias Otterbring, Dominic J. Packer, Anat Perry, Michael Bang Petersen, Arathy Puthillam, Julián C. Riaño-Moreno, Tobias Rothmund, Hernando Santamaría-García, Petra C. Schmid, Drozdstoy Stoyanov, Shruti Tewari, Bojan Todosijević, Manos Tsakiris, Hans H. Tung, Radu G. Umbreș, Edmunds Vanags, Madalina Vlasceanu, Andrew Vonasch, Meltem Yucel, Yucheng Zhang, Mohcine Abad, Eli Adler, Narin Akrawi, Hamza Alaoui Mdarhri, Hanane Amara, David M. Amodio, Benedict G. Antazo, Matthew Apps, F. Ceren Ay, Mouhamadou Hady Ba, Sergio Barbosa, Brock Bastian, Anton Berg, Maria P. Bernal-Zárate, Michael Bernstein, Michał Białek, Ennio Bilancini, Natalia Bogatyreva, Leonardo Boncinelli, Jonathan E. Booth, Sylvie Borau, Ondrej Buchel, C. Daryl Cameron, Chrissie F. Carvalho, Tatiana Celadin, Chiara Cerami, Hom Nath Chalise, Xiaojun Cheng, Luca Cian, Kate Cockcroft, Jane Conway, Mateo Andres Córdoba-Delgado, Chiara Crespi, Marie Crouzevialle, Jo Cutler, Marzena Cypryańska, Justyna Dabrowska, Michael A. Daniels, Victoria H. Davis, Pamala N. Dayley, Sylvain Delouvee, Ognjan Denkovski, Guillaume Dezecache, Nathan A. Dhaliwal, Alelie B. Diato, Roberto Di Paolo, Marianna Drosinou, Uwe Dulleck, Jānis Ekmanis, Arhan S. Ertan, Tom W. Etienne, Hapsa Hossain Farhana, Fahima Farkhari, Harry Farmer, Ali Fenwick, Kristijan Fidanovski, Terry Flew, Shona Fraser, Raymond Boadi Frempong, Jonathan A. Fugelsang, Jessica Gale, E. Begoña Garcia-Navarro, Prasad Garladinne, Oussama Ghajjou, Theofilos Gkinopoulos, Kurt Gray, Siobhán M. Griffin, Bjarki Gronfeldt, Mert Gümren, Ranju Lama Gurung, Eran Halperin, Elizabeth Harris, Volo Herzon, Matej Hruška, Guanxiong Huang, Matthias F. C. Hudecek, Ozan Isler, Simon Jangard, Frederik J. Jørgensen, Frank Kachanoff, John Kahn, Apsara Katuwal Dangol, Oleksandra Keudel, Lina Koppel, Mika Koverola, Emily Kubin, Anton Kunnari, Yordan Kutiyski, Oscar Laguna, Josh Leota, Eva Lermer, Jonathan Levy, Neil Levy, Chunyun Li, Elizabeth U. Long, Chiara Longoni, Marina Maglić, Darragh McCashin, Alexander L. Metcalf, Igor Mikloušić, Soulaimane El Mimouni, Asako Miura, Juliana Molina-Paredes, César Monroy-Fonseca, Elena Morales-Marente, David Moreau, Rafał Muda, Annalisa Myer, Kyle Nash, Tarik Nesh-Nash, Jonas P. Nitschke, Matthew S. Nurse, Yohsuke Ohtsubo, Victoria Oldemburgo de Mello, Cathal O’Madagain, Michal Onderco, M. Soledad Palacios-Galvez, Jussi Palomäki, Yafeng Pan, Zsófia Papp, Philip Pärnamets, Mariola Paruzel-Czachura, Zoran Pavlović, César Payán-Gómez, Silva Perander, Michael Mark Pitman, Rajib Prasad, Joanna Pyrkosz-Pacyna, Steve Rathje, Ali Raza, Gabriel G. Rêgo, Kasey Rhee, Claire E. Robertson, Iván Rodríguez-Pascual, Teemu Saikkonen, Octavio Salvador-Ginez, Waldir M. Sampaio, Gaia C. Santi, Natalia Santiago-Tovar, David Savage, Julian A. Scheffer, Philipp Schönegger, David T. Schultner, Enid M. Schutte, Andy Scott, Madhavi Sharma, Pujan Sharma, Ahmed Skali, David Stadelmann, Clara Alexandra Stafford, Dragan Stanojević, Anna Stefaniak, Anni Sternisko, Augustin Stoica, Kristina K. Stoyanova, Brent Strickland, Jukka Sundvall, Jeffrey P. Thomas, Gustav Tinghög, Benno Torgler, Iris J. Traast, Raffaele Tucciarelli, Michael Tyrala, Nick D. Ungson, Mete S. Uysal, Paul A. M. Van Lange, Jan-Willem van Prooijen, Dirk van Rooy, Daniel Västfjäll, Peter Verkoeijen, Joana B. Vieira, Christian von Sikorski, Alexander Cameron Walker, Jennifer Watermeyer, Erik Wetter, Ashley Whillans, Robin Willardt, Michael J. A. Wohl, Adrian Dominik Wójcik, Kaidi Wu, Yuki Yamada, Onurcan Yilmaz, Kumar Yogeeswaran, Carolin-Theresa Ziemer, Rolf A. Zwaan, and Paulo S. Boggio

Subjects
Science
Published
2022
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23. c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression

Author

Wen Jing Sim, Prasanna Vasudevan Iyengar, Dilraj Lama, Sarah Kit Leng Lui, Hsien Chun Ng, Lior Haviv-Shapira, Eytan Domany, Dennis Kappei, Tuan Zea Tan, Azad Saei, Patrick William Jaynes, Chandra Shekhar Verma, Alan Prem Kumar, Mathieu Rouanne, Hong Koo Ha, Camelia Radulescu, Peter ten Dijke, Pieter Johan Adam Eichhorn, and Jean Paul Thiery

Subjects
Science
Abstract

HGF/c-MET upregulation is frequent in bladder cancer. Here, the authors show that HGF induces EMT and invasion by stabilising TGFβ receptor through inhibition of the SMURF2 ligase, and the combined blockade of MAPK and TGFβ pathways suppresses HGF-mediated bladder cancer progression.

Published
2019
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24. Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression

Author

Lodoe Lama, Carolina Adura, Wei Xie, Daisuke Tomita, Taku Kamei, Vitaly Kuryavyi, Tasos Gogakos, Joshua I. Steinberg, Michael Miller, Lavoisier Ramos-Espiritu, Yasutomi Asano, Shogo Hashizume, Jumpei Aida, Toshihiro Imaeda, Rei Okamoto, Andy J. Jennings, Mayako Michino, Takanobu Kuroita, Andrew Stamford, Pu Gao, Peter Meinke, J. Fraser Glickman, Dinshaw J. Patel, and Thomas Tuschl

Subjects
Science
Abstract

Cyclic GMP-AMP synthase (cGAS) is involved in the modulation of inflammatory responses. Here, the authors present small-molecule inhibitors of human cGAS, characterize their interaction with the protein, and show that the compounds are active in interferon-producing cells including primary human macrophages.

Published
2019
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25. Caspases maintain tissue integrity by an apoptosis-independent inhibition of cell migration and invasion

Author

Anna Gorelick-Ashkenazi, Ron Weiss, Lena Sapozhnikov, Anat Florentin, Lama Tarayrah-Ibraheim, Dima Dweik, Keren Yacobi-Sharon, and Eli Arama

Subjects
Science
Abstract

In addition to regulating programmed cell death, caspases also have non-apoptotic roles. Here, the authors show that low level caspase activity prevents cell migration to maintain tissue integrity.

Published
2018
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26. Ternary complex of Kif2A-bound tandem tubulin heterodimers represents a kinesin-13-mediated microtubule depolymerization reaction intermediate

Author

Daria Trofimova, Mohammadjavad Paydar, Anthony Zara, Lama Talje, Benjamin H. Kwok, and John S. Allingham

Subjects
Science
Abstract

The kinesin-13 family of microtubule (MT) depolymerases are major regulators of MT dynamics. Here the authors provide insights into the MT depolymerization mechanism by solving the crystal structure of a kinesin-13 monomer (Kif2A) in complex with two bent αβ-tubulin heterodimers.

Published
2018
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27. Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice

Author

Jessica Vincent, Carolina Adura, Pu Gao, Antonio Luz, Lodoe Lama, Yasutomi Asano, Rei Okamoto, Toshihiro Imaeda, Jumpei Aida, Katherine Rothamel, Tasos Gogakos, Joshua Steinberg, Seth Reasoner, Kazuyoshi Aso, Thomas Tuschl, Dinshaw J. Patel, J. Fraser Glickman, and Manuel Ascano

Subjects
Science
Abstract

Upon DNA binding cyclic GMP-AMP synthase (cGAS) produces a cyclic dinucleotide, which leads to the upregulation of inflammatory genes. Here the authors develop small molecule cGAS inhibitors, functionally characterize them and present the inhibitor and DNA bound cGAS crystal structures, which will facilitate drug development.

Published
2017
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28. Negri bodies are viral factories with properties of liquid organelles

Author

Jovan Nikolic, Romain Le Bars, Zoé Lama, Nathalie Scrima, Cécile Lagaudrière-Gesbert, Yves Gaudin, and Danielle Blondel

Subjects
Science
Abstract

Negative strand RNA viruses, such as rabies virus, induce formation of cytoplasmic inclusions for genome replication. Here, Nikolic et al. show that these so-called Negri bodies (NBs) have characteristics of liquid organelles and they identify the minimal protein domains required for NB formation.

Published
2017
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29. A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling

Author

Alexandre Beautrait, Justine S. Paradis, Brandon Zimmerman, Jenna Giubilaro, Ljiljana Nikolajev, Sylvain Armando, Hiroyuki Kobayashi, Lama Yamani, Yoon Namkung, Franziska M. Heydenreich, Etienne Khoury, Martin Audet, Philippe P. Roux, Dmitry B. Veprintsev, Stéphane A. Laporte, and Michel Bouvier

Subjects
Science
Abstract

Beta-arrestins play central roles in the mechanisms regulating GPCR signalling and trafficking. Here the authors identify a selective inhibitor of the interaction between β-arrestin and the β2-adaptin subunit of the clathrin adaptor protein AP-2, which they use to dissect the role of the β-arrestin/β2-adaptin interaction in GPCR signalling.

Published
2017
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30. Author Correction: c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression

Author

Sim, Wen Jing, Iyengar, Prasanna Vasudevan, Lama, Dilraj, Lui, Sarah Kit Leng, Ng, Hsien Chun, Haviv-Shapira, Lior, Domany, Eytan, Kappei, Dennis, Tan, Tuan Zea, Saei, Azad, Jaynes, Patrick William, Verma, Chandra Shekhar, Kumar, Alan Prem, Rouanne, Mathieu, Ha, Hong Koo, Radulescu, Camelia, ten Dijke, Peter, Eichhorn, Pieter Johan Adam, and Thiery, Jean Paul

Published
2019
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31. c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression

Author

Sim, Wen Jing, Iyengar, Prasanna Vasudevan, Lama, Dilraj, Lui, Sarah Kit Leng, Ng, Hsien Chun, Haviv-Shapira, Lior, Domany, Eytan, Kappei, Dennis, Tan, Tuan Zea, Saei, Azad, Jaynes, Patrick William, Verma, Chandra Shekhar, Kumar, Alan Prem, Rouanne, Mathieu, Ha, Hong Koo, Radulescu, Camelia, ten Dijke, Peter, Eichhorn, Pieter Johan Adam, and Thiery, Jean Paul

Published
2019
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32. Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression

Author

Lama, Lodoe, Adura, Carolina, Xie, Wei, Tomita, Daisuke, Kamei, Taku, Kuryavyi, Vitaly, Gogakos, Tasos, Steinberg, Joshua I., Miller, Michael, Ramos-Espiritu, Lavoisier, Asano, Yasutomi, Hashizume, Shogo, Aida, Jumpei, Imaeda, Toshihiro, Okamoto, Rei, Jennings, Andy J., Michino, Mayako, Kuroita, Takanobu, Stamford, Andrew, Gao, Pu, Meinke, Peter, Glickman, J. Fraser, Patel, Dinshaw J., and Tuschl, Thomas

Published
2019
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33. Author Correction: c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression

Author

Wen Jing Sim, Prasanna Vasudevan Iyengar, Dilraj Lama, Sarah Kit Leng Lui, Hsien Chun Ng, Lior Haviv-Shapira, Eytan Domany, Dennis Kappei, Tuan Zea Tan, Azad Saei, Patrick William Jaynes, Chandra Shekhar Verma, Alan Prem Kumar, Mathieu Rouanne, Hong Koo Ha, Camelia Radulescu, Peter ten Dijke, Pieter Johan Adam Eichhorn, and Jean Paul Thiery

Subjects
Science
Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Published
2019
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35. Publisher Correction: Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice

Author

Jessica Vincent, Carolina Adura, Pu Gao, Antonio Luz, Lodoe Lama, Yasutomi Asano, Rei Okamoto, Toshihiro Imaeda, Jumpei Aida, Katherine Rothamel, Tasos Gogakos, Joshua Steinberg, Seth Reasoner, Kazuyoshi Aso, Thomas Tuschl, Dinshaw J. Patel, J. Fraser Glickman, and Manuel Ascano

Subjects
Science
Abstract

The previously published version of this Article contained errors in Fig. 6. In panel h the units of the x axis were incorrectly given as mM and should have been given as µM. Also, the IC50s for RU.365, RU.332 and RU.521 within panel h were incorrectly given as mM and should have been given as µM. These errors have been corrected in both the PDF and HTML versions of the Article.

Published
2017
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