Search

Your search keyword '"Max Friesen"' showing total 1 results
Start Over Author "Max Friesen" Journal nature communications
1 results on '"Max Friesen"'

1. The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance

Author

Alessandra Dall’Agnese, Jesse M. Platt, Ming M. Zheng, Max Friesen, Giuseppe Dall’Agnese, Alyssa M. Blaise, Jessica B. Spinelli, Jonathan E. Henninger, Erin N. Tevonian, Nancy M. Hannett, Charalampos Lazaris, Hannah K. Drescher, Lea M. Bartsch, Henry R. Kilgore, Rudolf Jaenisch, Linda G. Griffith, Ibrahim I. Cisse, Jacob F. Jeppesen, Tong I. Lee, and Richard A. Young

Subjects
Science
Abstract

The authors find that the insulin receptor forms dynamic clusters during insulin signaling and that these clusters become dysfunctional in insulin resistance. This dysfunction is partially rescued by metformin, a drug used to treat type 2 diabetes.

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results