18 results on '"Qiao Zhang"'
Search Results
2. Grave-to-cradle photothermal upcycling of waste polyesters over spent LiCoO2
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Xiangxi Lou, Penglei Yan, Binglei Jiao, Qingye Li, Panpan Xu, Lei Wang, Liang Zhang, Muhan Cao, Guiling Wang, Zheng Chen, Qiao Zhang, and Jinxing Chen
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Science - Abstract
Abstract Lithium-ion batteries (LIBs) and plastics are pivotal components of modern society; nevertheless, their escalating production poses formidable challenges to resource sustainability and ecosystem integrity. Here, we showcase the transformation of spent lithium cobalt oxide (LCO) cathodes into photothermal catalysts capable of catalyzing the upcycling of diverse waste polyesters into high-value monomers. The distinctive Li deficiency in spent LCO induces a contraction in the Co−O6 unit cell, boosting the monomer yield exceeding that of pristine LCO by a factor of 10.24. A comprehensive life-cycle assessment underscores the economic viability of utilizing spent LCO as a photothermal catalyst, yielding returns of 129.6 $·kgLCO −1, surpassing traditional battery recycling returns (13–17 $·kgLCO −1). Solar-driven recycling 100,000 tons of PET can reduce 3.459 × 1011 kJ of electric energy and decrease 38,716 tons of greenhouse gas emissions. This work unveils a sustainable solution for the management of spent LIBs and plastics.
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- 2024
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3. Proteomic characterization identifies clinically relevant subgroups of soft tissue sarcoma
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Shaoshuai Tang, Yunzhi Wang, Rongkui Luo, Rundong Fang, Yufeng Liu, Hang Xiang, Peng Ran, Yexin Tong, Mingjun Sun, Subei Tan, Wen Huang, Jie Huang, Jiacheng Lv, Ning Xu, Zhenmei Yao, Qiao Zhang, Ziyan Xu, Xuetong Yue, Zixiang Yu, Sujie Akesu, Yuqin Ding, Chen Xu, Weiqi Lu, Yuhong Zhou, Yingyong Hou, and Chen Ding
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Science - Abstract
Abstract Soft tissue sarcoma is a broad family of mesenchymal malignancies exhibiting remarkable histological diversity. We portray the proteomic landscape of 272 soft tissue sarcomas representing 12 major subtypes. Hierarchical classification finds the similarity of proteomic features between angiosarcoma and epithelial sarcoma, and elevated expression of SHC1 in AS and ES is correlated with poor prognosis. Moreover, proteomic clustering classifies patients of soft tissue sarcoma into 3 proteomic clusters with diverse driven pathways and clinical outcomes. In the proteomic cluster featured with the high cell proliferation rate, APEX1 and NPM1 are found to promote cell proliferation and drive the progression of cancer cells. The classification based on immune signatures defines three immune subtypes with distinctive tumor microenvironments. Further analysis illustrates the potential association between immune evasion markers (PD-L1 and CD80) and tumor metastasis in soft tissue sarcoma. Overall, this analysis uncovers sarcoma-type-specific changes in proteins, providing insights about relationships of soft tissue sarcoma.
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- 2024
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4. Mechanistic insights into C-C coupling in electrochemical CO reduction using gold superlattices
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Xiaoju Yang, Chao Rong, Li Zhang, Zhenkun Ye, Zhiming Wei, Chengdi Huang, Qiao Zhang, Qing Yuan, Yueming Zhai, Fu-Zhen Xuan, Bingjun Xu, Bowei Zhang, and Xuan Yang
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Science - Abstract
Abstract Developing in situ/operando spectroscopic techniques with high sensitivity and reproducibility is of great importance for mechanistic investigations of surface-mediated electrochemical reactions. Herein, we report the fabrication of highly ordered rhombic gold nanocube superlattices (GNSs) as substrates for surface-enhanced infrared absorption spectroscopy (SEIRAS) with significantly enhanced SEIRA effect, which can be controlled by manipulating the randomness of GNSs. Finite difference time domain simulations reveal that the electromagnetic effect accounts for the significantly improved spectroscopic vibrations on the GNSs. In situ SEIRAS results show that the vibrations of CO on the Cu2O surfaces have been enhanced by 2.4 ± 0.5 and 18.0 ± 1.3 times using GNSs as substrates compared to those on traditional chemically deposited gold films in acidic and neutral electrolytes, respectively. Combined with isotopic labeling experiments, the reaction mechanisms for C-C coupling of CO electroreduction on Cu-based catalysts are revealed using the GNSs substrates.
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- 2024
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5. Elucidating the structure-stability relationship of Cu single-atom catalysts using operando surface-enhanced infrared absorption spectroscopy
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Li Zhang, Xiaoju Yang, Qing Yuan, Zhiming Wei, Jie Ding, Tianshu Chu, Chao Rong, Qiao Zhang, Zhenkun Ye, Fu-Zhen Xuan, Yueming Zhai, Bowei Zhang, and Xuan Yang
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Science - Abstract
Abstract Understanding the structure-stability relationship of catalysts is imperative for the development of high-performance electrocatalytic devices. Herein, we utilize operando attenuated total reflectance surface-enhanced infrared absorption spectroscopy (ATR-SEIRAS) to quantitatively monitor the evolution of Cu single-atom catalysts (SACs) during the electrochemical reduction of CO2 (CO2RR). Cu SACs are converted into 2-nm Cu nanoparticles through a reconstruction process during CO2RR. The evolution rate of Cu SACs is highly dependent on the substrates of the catalysts due to the coordination difference. Density functional theory calculations demonstrate that the stability of Cu SACs is highly dependent on their formation energy, which can be manipulated by controlling the affinity between Cu sites and substrates. This work highlights the use of operando ATR-SEIRAS to achieve mechanistic understanding of structure-stability relationship for long-term applications.
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- 2023
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6. Atomic high-spin cobalt(II) center for highly selective electrochemical CO reduction to CH3OH
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Jie Ding, Zhiming Wei, Fuhua Li, Jincheng Zhang, Qiao Zhang, Jing Zhou, Weijue Wang, Yuhang Liu, Zhen Zhang, Xiaozhi Su, Runze Yang, Wei Liu, Chenliang Su, Hong Bin Yang, Yanqiang Huang, Yueming Zhai, and Bin Liu
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Science - Abstract
Abstract In this work, via engineering the conformation of cobalt active center in cobalt phthalocyanine molecular catalyst, the catalytic efficiency of electrochemical carbon monoxide reduction to methanol can be dramatically tuned. Based on a collection of experimental investigations and density functional theory calculations, it reveals that the electron rearrangement of the Co 3d orbitals of cobalt phthalocyanine from the low-spin state (S = 1/2) to the high-spin state (S = 3/2), induced by molecular conformation change, is responsible for the greatly enhanced CO reduction reaction performance. Operando attenuated total reflectance surface-enhanced infrared absorption spectroscopy measurements disclose accelerated hydrogenation of CORR intermediates, and kinetic isotope effect validates expedited proton-feeding rate over cobalt phthalocyanine with high-spin state. Further natural population analysis and density functional theory calculations demonstrate that the high spin Co2+ can enhance the electron backdonation via the d xz /d yz −2π* bond and weaken the C-O bonding in *CO, promoting hydrogenation of CORR intermediates.
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- 2023
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7. Proteogenomics of different urothelial bladder cancer stages reveals distinct molecular features for papillary cancer and carcinoma in situ
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Zhenmei Yao, Ning Xu, Guoguo Shang, Haixing Wang, Hui Tao, Yunzhi Wang, Zhaoyu Qin, Subei Tan, Jinwen Feng, Jiajun Zhu, Fahan Ma, Sha Tian, Qiao Zhang, Yuanyuan Qu, Jun Hou, Jianming Guo, Jianyuan Zhao, Yingyong Hou, and Chen Ding
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Science - Abstract
Abstract The progression of urothelial bladder cancer (UC) is a complicated multi-step process. We perform a comprehensive multi-omics analysis of 448 samples from 190 UC patients, covering the whole spectrum of disease stages and grades. Proteogenomic integration analysis indicates the mutations of HRAS regulated mTOR signaling to form urothelial papilloma rather than papillary urothelial cancer (PUC). DNA damage is a key signaling pathway in the progression of carcinoma in situ (CIS) and related to APOBEC signature. Glucolipid metabolism increase and lower immune cell infiltration are associated with PUC compared to CIS. Proteomic analysis distinguishes the origins of invasive tumors (PUC-derived and CIS-derived), related to distinct clinical prognosis and molecular features. Additionally, loss of RBPMS, associated with CIS-derived tumors, is validated to increase the activity of AP-1 and promote metastasis. This study reveals the characteristics of two distinct branches (PUC and CIS) of UC progression and may eventually benefit clinical practice.
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- 2023
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8. N-terminal α-amino SUMOylation of cofilin-1 is critical for its regulation of actin depolymerization
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Weiji Weng, Xiaokun Gu, Yang Yang, Qiao Zhang, Qi Deng, Jie Zhou, Jinke Cheng, Michael X. Zhu, Junfeng Feng, Ou Huang, and Yong Li
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Science - Abstract
Abstract Small ubiquitin-like modifier (SUMO) typically conjugates to target proteins through isopeptide linkage to the ε-amino group of lysine residues. This posttranslational modification (PTM) plays pivotal roles in modulating protein function. Cofilins are key regulators of actin cytoskeleton dynamics and are well-known to undergo several different PTMs. Here, we show that cofilin-1 is conjugated by SUMO1 both in vitro and in vivo. Using mass spectrometry and biochemical and genetic approaches, we identify the N-terminal α-amino group as the SUMO-conjugation site of cofilin-1. Common to conventional SUMOylation is that the N-α-SUMOylation of cofilin-1 is also mediated by SUMO activating (E1), conjugating (E2), and ligating (E3) enzymes and reversed by the SUMO deconjugating enzyme, SENP1. Specific to the N-α-SUMOylation is the physical association of the E1 enzyme to the substrate, cofilin-1. Using F-actin co-sedimentation and actin depolymerization assays in vitro and fluorescence staining of actin filaments in cells, we show that the N-α-SUMOylation promotes cofilin-1 binding to F-actin and cofilin-induced actin depolymerization. This covalent conjugation by SUMO at the N-α amino group of cofilin-1, rather than at an internal lysine(s), serves as an essential PTM to tune cofilin-1 function during regulation of actin dynamics.
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- 2023
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9. Comprehensive proteogenomic characterization of early duodenal cancer reveals the carcinogenesis tracks of different subtypes
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Lingling Li, Dongxian Jiang, Hui Liu, Chunmei Guo, Rui Zhao, Qiao Zhang, Chen Xu, Zhaoyu Qin, Jinwen Feng, Yang Liu, Haixing Wang, Weijie Chen, Xue Zhang, Bin Li, Lin Bai, Sha Tian, Subei Tan, Zixiang Yu, Lingli Chen, Jie Huang, Jian-Yuan Zhao, Yingyong Hou, and Chen Ding
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Science - Abstract
Duodenal cancer (DC) has complex subtypes and undergoes complicated morphological changes throughout progression, so understanding the molecular basis is crucial. Here, the authors perform a proteogenomics analysis of 156 DCs, revealing molecular subtypes as well as the roles of smoking, AARS1 and PARP1.
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- 2023
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10. Integrative proteogenomic characterization of early esophageal cancer
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Lingling Li, Dongxian Jiang, Qiao Zhang, Hui Liu, Fujiang Xu, Chunmei Guo, Zhaoyu Qin, Haixing Wang, Jinwen Feng, Yang Liu, Weijie Chen, Xue Zhang, Lin Bai, Sha Tian, Subei Tan, Chen Xu, Qi Song, Yalan Liu, Yunshi Zhong, Tianyin Chen, Pinghong Zhou, Jian-Yuan Zhao, Yingyong Hou, and Chen Ding
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Science - Abstract
The progression of oesophageal squamous cell carcinoma (ESCC) from early to advanced stages requires comprehensive molecular characterisation. Here, the authors perform a proteogenomics analysis of ESCC patient samples across nine histopathological stages and three phases, identifying key alterations and paths for progression.
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- 2023
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11. Modeling early stage atherosclerosis in a primary human vascular microphysiological system
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Xu Zhang, Muath Bishawi, Ge Zhang, Varun Prasad, Ellen Salmon, Jason J. Breithaupt, Qiao Zhang, and George A. Truskey
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Science - Abstract
Human microphysiological systems (MPS) have some advantages over animal models to study the mechanisms of disease. Here the authors use a tissue-engineered blood vessel MPS to create a model of early stage atherosclerosis and assess the effect of several drugs.
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- 2020
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12. Imaging the kinetics of anisotropic dissolution of bimetallic core–shell nanocubes using graphene liquid cells
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Lei Chen, Alberto Leonardi, Jun Chen, Muhan Cao, Na Li, Dong Su, Qiao Zhang, Michael Engel, and Xingchen Ye
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Science - Abstract
Rational design of multicomponent nanocrystals requires atomic-level understanding of reaction kinetics. Here, the authors apply single-particle liquid-cell electron microscopy imaging coupled with atomistic simulations to understand pathways and rates of bimetallic core-shell nanocubes undergoing oxidative dissolution.
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- 2020
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13. The microprotein Minion controls cell fusion and muscle formation
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Qiao Zhang, Ajay A. Vashisht, Jason O’Rourke, Stéphane Y Corbel, Rita Moran, Angelica Romero, Loren Miraglia, Jia Zhang, Eric Durrant, Christian Schmedt, Srinath C. Sampath, and Srihari C. Sampath
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Science - Abstract
Cellular fusion is essential for skeletal muscle development. Here the authors identify Minion as a microprotein required for myoblast fusion and skeletal muscle formation, and show that co-expression of Minion and Myomaker is sufficient to induce cytoskeletal rearrangement and cell fusion even in non-muscle cells.
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- 2017
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14. Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition
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Jian Fang, Jingdong Cheng, Jiaolong Wang, Qiao Zhang, Mengjie Liu, Rui Gong, Ping Wang, Xiaodan Zhang, Yangyang Feng, Wenxian Lan, Zhou Gong, Chun Tang, Jiemin Wong, Huirong Yang, Chunyang Cao, and Yanhui Xu
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Science - Abstract
UHRF1 is involved in the maintenance of DNA methylation, but the regulatory mechanism of this epigenetic regulator is unclear. Here, the authors show that it has a closed conformation and are able to make conclusions about the mechanism of recognition of epigenetic marks.
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- 2016
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15. Integrative proteogenomic characterization of early esophageal cancer
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Lin Bai, Hou Yingyong, Qiao Zhang, Jian-Yuan Zhao, Dan Shen, Xue Zhang, Yang Liu, Sha Tian, Chen Ding, Hui Liu, Lingling Li, Fujiang Xu, Haixing Wang, Weijie Chen, Pinghong Zhou, Chen Xu, Dongxian Jiang, Jinwen Feng, Qi Song, Yalan Liu, Zhaoyu Qin, Subei Tan, Yun-Shi Zhong, and T. Chen
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Multidisciplinary ,business.industry ,medicine ,Proteogenomic Characterization ,General Physics and Astronomy ,Computational biology ,General Chemistry ,Esophageal cancer ,medicine.disease ,business ,General Biochemistry, Genetics and Molecular Biology - Abstract
Esophageal squamous cell carcinoma (ESCC) is malignant while the carcinogenesis is still unclear. Here, we perform a comprehensive multi-omics analysis of 786 trace-tumor-samples from 154 ESCC patients, covering 9 histopathological stages and 3 phases. Proteogenomics elucidates cancer-driving waves in ESCC progression, and reveals the molecular characterization of alcohol drinking habit associated signatures. We discover chromosome 3q gain functions in the transmit from nontumor to intraepithelial neoplasia phases, and find TP53 mutation enhances DNA replication in intraepithelial neoplasia phase. The mutations of AKAP9 and MCAF1 upregulate glycolysis and Wnt signaling, respectively, in advanced-stage ESCC phase. Six major tracks related to different clinical features during ESCC progression are identified, which is validated by an independent cohort with another 256 samples. Hyperphosphorylated phosphoglycerate kinase 1 (PGK1, S203) is considered as a drug target in ESCC progression. This study provides insight into the understanding of ESCC molecular mechanism and the development of therapeutic targets.
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- 2023
16. Modeling early stage atherosclerosis in a primary human vascular microphysiological system
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Jason J. Breithaupt, Muath Bishawi, Ellen Salmon, Ge Zhang, Qiao Zhang, George A. Truskey, Xu Zhang, and Varun Prasad
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congenital, hereditary, and neonatal diseases and abnormalities ,Science ,General Physics and Astronomy ,Pharmacology ,Nitric Oxide ,Models, Biological ,General Biochemistry, Genetics and Molecular Biology ,Article ,Monocytes ,Nitric oxide ,chemistry.chemical_compound ,In vivo ,Cell Adhesion ,Medicine ,Humans ,Cell adhesion ,skin and connective tissue diseases ,lcsh:Science ,Cells, Cultured ,Foam cell ,Cell Proliferation ,Multidisciplinary ,Cardiovascular models ,Tissue Engineering ,business.industry ,Tumor Necrosis Factor-alpha ,Monocyte ,nutritional and metabolic diseases ,General Chemistry ,Atherosclerosis ,Biomechanical Phenomena ,Endothelial stem cell ,Lipoproteins, LDL ,Arterioles ,medicine.anatomical_structure ,chemistry ,lcsh:Q ,business ,Perfusion ,Blood vessel ,Foam Cells - Abstract
Novel atherosclerosis models are needed to guide clinical therapy. Here, we report an in vitro model of early atherosclerosis by fabricating and perfusing multi-layer arteriole-scale human tissue-engineered blood vessels (TEBVs) by plastic compression. TEBVs maintain mechanical strength, vasoactivity, and nitric oxide (NO) production for at least 4 weeks. Perfusion of TEBVs at a physiological shear stress with enzyme-modified low-density-lipoprotein (eLDL) with or without TNFα promotes monocyte accumulation, reduces vasoactivity, alters NO production, which leads to endothelial cell activation, monocyte accumulation, foam cell formation and expression of pro-inflammatory cytokines. Removing eLDL leads to recovery of vasoactivity, but not loss of foam cells or recovery of permeability, while pretreatment with lovastatin or the P2Y11 inhibitor NF157 reduces monocyte accumulation and blocks foam cell formation. Perfusion with blood leads to increased monocyte adhesion. This atherosclerosis model can identify the role of drugs on specific vascular functions that cannot be assessed in vivo., Human microphysiological systems (MPS) have some advantages over animal models to study the mechanisms of disease. Here the authors use a tissue-engineered blood vessel MPS to create a model of early stage atherosclerosis and assess the effect of several drugs.
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- 2020
17. The microprotein Minion controls cell fusion and muscle formation
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Srihari C. Sampath, Christian Schmedt, Rita Moran, Stéphane Y. Corbel, Ajay A. Vashisht, Srinath C Sampath, Eric Durrant, Jason O'Rourke, Loren Miraglia, Angelica Romero, Qiao Zhang, and Jia Zhang
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0301 basic medicine ,Male ,Genotype ,Science ,Cellular differentiation ,General Physics and Astronomy ,Biology ,General Biochemistry, Genetics and Molecular Biology ,Article ,Mass Spectrometry ,Myoblasts ,03 medical and health sciences ,Mice ,Open Reading Frames ,medicine ,Animals ,Regeneration ,Cytoskeleton ,Muscle, Skeletal ,3' Untranslated Regions ,Lung ,Genetics ,Mice, Inbred C3H ,Multidisciplinary ,Cell fusion ,Myogenesis ,Stem Cells ,Skeletal muscle ,Membrane Proteins ,Cell Differentiation ,General Chemistry ,Transmembrane protein ,Cell biology ,Mice, Inbred C57BL ,Open reading frame ,030104 developmental biology ,medicine.anatomical_structure ,Minion ,Female ,CRISPR-Cas Systems ,Function (biology) - Abstract
Although recent evidence has pointed to the existence of small open reading frame (smORF)-encoded microproteins in mammals, their function remains to be determined. Skeletal muscle development requires fusion of mononuclear progenitors to form multinucleated myotubes, a critical but poorly understood process. Here we report the identification of Minion (microprotein inducer of fusion), a smORF encoding an essential skeletal muscle specific microprotein. Myogenic progenitors lacking Minion differentiate normally but fail to form syncytial myotubes, and Minion-deficient mice die perinatally and demonstrate a marked reduction in fused muscle fibres. The fusogenic activity of Minion is conserved in the human orthologue, and co-expression of Minion and the transmembrane protein Myomaker is sufficient to induce cellular fusion accompanied by rapid cytoskeletal rearrangement, even in non-muscle cells. These findings establish Minion as a novel microprotein required for muscle development, and define a two-component programme for the induction of mammalian cell fusion. Moreover, these data also significantly expand the known functions of smORF-encoded microproteins., Cellular fusion is essential for skeletal muscle development. Here the authors identify Minion as a microprotein required for myoblast fusion and skeletal muscle formation, and show that co-expression of Minion and Myomaker is sufficient to induce cytoskeletal rearrangement and cell fusion even in non-muscle cells.
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- 2017
18. Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition
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Jiemin Wong, Xiaodan Zhang, Zhou Gong, Chun Tang, Wenxian Lan, Ping Wang, Rui Gong, Yanhui Xu, Chunyang Cao, Mengjie Liu, Jiaolong Wang, Jian Fang, Jingdong Cheng, Qiao Zhang, Yangyang Feng, and Huirong Yang
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0301 basic medicine ,DNA (Cytosine-5-)-Methyltransferase 1 ,Models, Molecular ,Tudor domain ,Science ,Recombinant Fusion Proteins ,Ubiquitin-Protein Ligases ,Molecular Sequence Data ,General Physics and Astronomy ,Gene Expression ,Crystallography, X-Ray ,General Biochemistry, Genetics and Molecular Biology ,Article ,Protein Structure, Secondary ,Histones ,03 medical and health sciences ,chemistry.chemical_compound ,Mice ,Escherichia coli ,Animals ,Amino Acid Sequence ,DNA (Cytosine-5-)-Methyltransferases ,Binding site ,Cloning, Molecular ,chemistry.chemical_classification ,DNA ligase ,Multidisciplinary ,Binding Sites ,biology ,Nuclear Proteins ,General Chemistry ,DNA ,DNA Methylation ,Molecular biology ,Chromatin ,Cell biology ,Protein Structure, Tertiary ,030104 developmental biology ,Histone ,chemistry ,PHD finger ,DNA methylation ,biology.protein ,CCAAT-Enhancer-Binding Proteins ,NIH 3T3 Cells ,Protein Binding - Abstract
UHRF1 is an important epigenetic regulator for maintenance DNA methylation. UHRF1 recognizes hemi-methylated DNA (hm-DNA) and trimethylation of histone H3K9 (H3K9me3), but the regulatory mechanism remains unknown. Here we show that UHRF1 adopts a closed conformation, in which a C-terminal region (Spacer) binds to the tandem Tudor domain (TTD) and inhibits H3K9me3 recognition, whereas the SET-and-RING-associated (SRA) domain binds to the plant homeodomain (PHD) and inhibits H3R2 recognition. Hm-DNA impairs the intramolecular interactions and promotes H3K9me3 recognition by TTD–PHD. The Spacer also facilitates UHRF1–DNMT1 interaction and enhances hm-DNA-binding affinity of the SRA. When TTD–PHD binds to H3K9me3, SRA-Spacer may exist in a dynamic equilibrium: either recognizes hm-DNA or recruits DNMT1 to chromatin. Our study reveals the mechanism for regulation of H3K9me3 and hm-DNA recognition by URHF1., UHRF1 is involved in the maintenance of DNA methylation, but the regulatory mechanism of this epigenetic regulator is unclear. Here, the authors show that it has a closed conformation and are able to make conclusions about the mechanism of recognition of epigenetic marks.
- Published
- 2016
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