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Start Over Author "Yi-Li Feng" Journal nature communications
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1. DNA nicks induce mutational signatures associated with BRCA1 deficiency

Author

Yi-Li Feng, Qian Liu, Ruo-Dan Chen, Si-Cheng Liu, Zhi-Cheng Huang, Kun-Ming Liu, Xiao-Ying Yang, and An-Yong Xie

Subjects
Science
Abstract

It remains unclear how BRCA1-associated mutational sigantures are generated in cancer. Here, the authors develop nCas9-based approaches to uncover that aberrant repair of one-ended DSBs converted from DNA nicks by replication, not that of two-ended DSBs, induces such mutational signatures.

Published
2022
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