1. A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12
- Author
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Wen Di, Li Li, Jianfeng Zhou, Guangshi Tao, Gang Ma, Shulan Zhang, Hongbing Shen, Fulin Qiang, Hongbin Xu, Ting Hu, Sufang Wu, Zhedong Han, Xiaomei Luan, Jian Shen, Ling Xi, Shaoshuai Wang, Keng Shen, Yuanming Shen, Kecheng Huang, Dongxin Lin, Dao Wen Wang, Weiguo Lv, Fangxu Tang, Shuangyun Chen, Youji Feng, Zhuang Li, Xiaojie Song, Yang Wen, Zhibin Hu, Jiangping Wu, Xiaobing Han, Dan Liu, Li Liu, Chen Wu, Hu Ding, Hui Xing, Zehua Wang, Xiong Li, Jibin Liu, Zhiying Lei, Qian Song, Yanming Jiang, Hongying He, Shuang Li, Yuan Zhang, Lixing Yan, Xiaodong Cheng, Hang Zhou, Jihong Liu, Pengpeng Qu, Zheng Li, Yongyong Shi, Li Wu, Jiawei Shen, Ee Gong, Dongrui Deng, Jie Jiang, Zhiqiang Li, Lin He, Cunjian Yi, Qinghua Zhang, Zhijun Yang, Xing Xie, Yile Chen, Jianhua Chen, Cui Liu, Zhilan Chen, Xiaojun Chen, Ru Yang, Yujuan Fan, Shandong Pan, Yao Jia, Wenjin Li, Jiang Yu, Chuping Wang, Shixuan Wang, Xiaoxia Hu, Limei Zhou, Xiaoping Miao, Hui Wang, Yan Shen, Ding Ma, Zhongqiu Lin, and Minjie Chu
- Subjects
Adult ,Han chinese ,China ,Uterine Cervical Neoplasms ,Genome-wide association study ,Biology ,Polymorphism, Single Nucleotide ,Asian People ,Genetics ,medicine ,Odds Ratio ,Humans ,Genetic Predisposition to Disease ,Cervical cancer ,fungi ,Computational Biology ,Reproducibility of Results ,Middle Aged ,medicine.disease ,Genetic Loci ,Case-Control Studies ,Susceptibility locus ,Female ,Chromosomes, Human, Pair 4 ,Chromosomes, Human, Pair 17 ,Follow-Up Studies ,Genome-Wide Association Study - Abstract
To identify new genetic risk factors for cervical cancer, we conducted a genome-wide association study in the Han Chinese population. The initial discovery set included 1,364 individuals with cervical cancer (cases) and 3,028 female controls, and we selected a 'stringently matched samples' subset (829 cases and 990 controls) from the discovery set on the basis of principal component analysis; the follow-up stages included two independent sample sets (1,824 cases and 3,808 controls for follow-up 1 and 2,343 cases and 3,388 controls for follow-up 2). We identified strong evidence of associations between cervical cancer and two new loci: 4q12 (rs13117307, Pcombined, stringently matched=9.69×10(-9), per-allele odds ratio (OR)stringently matched=1.26) and 17q12 (rs8067378, Pcombined, stringently matched=2.00×10(-8), per-allele ORstringently matched=1.18). We additionally replicated an association between HLA-DPB1 and HLA-DPB2 (HLA-DPB1/2) at 6p21.32 and cervical cancer (rs4282438, Pcombined, stringently matched=4.52×10(-27), per-allele ORstringently matched=0.75). Our findings provide new insights into the genetic etiology of cervical cancer.
- Published
- 2013