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Your search keyword '"Li, Huayue"' showing total 5 results
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3. Genetic Manipulation of an Aminotransferase Family Gene dtlAActivates Youssoufenes in Marine-Derived Streptomyces youssoufiensis

Author

Li, Huayue, Liu, Jing, Deng, Zirong, Li, Tong, Liu, Zengzhi, Che, Qian, and Li, Wenli

Abstract

Disruption of an aminotransferase family gene dtlAactivated the production of a novel dimeric benzoic polyene acids (BPAs), named youssoufene A1 (1), along with four new (2–5, youssoufenes B1–B4) and a known (6) monomeric BPA in the marine-derived Streptomyces youssoufiensisOUC6819. The structures of 1–5were elucidated by extensive spectroscopic and computational approaches. Youssoufene A1 (1) exhibited notably increased growth inhibition (MIC = 12.5 μg/mL) against multidrug resistant Enterococcus faecaliscompared to monomeric structures (2–6).

Published
2020
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5. Genetic Manipulation of an Aminotransferase Family Gene dtlA Activates Youssoufenes in Marine-Derived Streptomyces youssoufiensis .

Author

Li H, Liu J, Deng Z, Li T, Liu Z, Che Q, and Li W

Subjects
Molecular Structure, Polyenes metabolism, Stereoisomerism, Transaminases genetics, Polyenes chemistry, Streptomyces enzymology, Transaminases metabolism
Abstract

Disruption of an aminotransferase family gene dtlA activated the production of a novel dimeric benzoic polyene acids (BPAs), named youssoufene A1 ( 1 ), along with four new ( 2 - 5 , youssoufenes B1-B4) and a known ( 6 ) monomeric BPA in the marine-derived Streptomyces youssoufiensis OUC6819. The structures of 1 - 5 were elucidated by extensive spectroscopic and computational approaches. Youssoufene A1 ( 1 ) exhibited notably increased growth inhibition (MIC = 12.5 μg/mL) against multidrug resistant Enterococcus faecalis compared to monomeric structures ( 2 - 6 ).

Published
2020
Full Text
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