1. Discovery of Populusone, a Skeletal Stimulator of Umbilical Cord Mesenchymal Stem Cells from Populus euphratica Exudates
- Author
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Jia-Wang Liu, Yuanyuan Zhang, Yong-Ming Yan, Yanxia Zhu, Yong-Xian Cheng, Yue Zeng, Fu-Ying Qin, Ya-Bin Jiao, and Kai-Xin Liu
- Subjects
Cellular differentiation ,Carbon skeleton ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Umbilical cord ,Umbilical Cord ,chemistry.chemical_compound ,Biosynthesis ,medicine ,Physical and Theoretical Chemistry ,biology ,Molecular Structure ,010405 organic chemistry ,Organic Chemistry ,Mesenchymal stem cell ,Cell Differentiation ,Mesenchymal Stem Cells ,biology.organism_classification ,0104 chemical sciences ,Cell biology ,medicine.anatomical_structure ,Populus ,chemistry ,Keratinocyte ,Populus euphratica - Abstract
Populusone (1), a cembrane-type macrocyclic trinorditerpenoid, was isolated from the exudates of Populus euphratica and shown to have an unprecedented carbon skeleton, The structure was identified using spectroscopic methods and X-ray crystallography. A possible pathway for the biosynthesis of 1 was proposed. Populusone (10 μM) was found to promote proliferation and differentiation of umbilical cord derived mesenchymal stem cells into keratinocyte like cells.
- Published
- 2019