1. A New Approach to Oxidative Stress and Inflammatory Signaling during Labour in Healthy Mothers and Neonates
- Author
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Mario Pulido-Moran, Olga Ocón, Naroa Kajarabille, Sonia Prados, Jesús Florido, Julio J. Ochoa, Catalina de Paco, Javier Díaz-Castro, [Díaz-Castro,J, Kajarabille,N, Pulido-Moran,M, Ochoa,JJ] Department of Physiology, University of Granada, Granada, Spain. Institute of Nutrition and Food Technology 'Jose Mataix', University of Granada, Granada, Spain. [Florido,J, Prados,S, de Paco,C, and Ocon,O] Department Obtetrics and Gynecology, School of Medicine, University of Granada, Granada, Spain. Service of Obstetrics and Gynecology, University Hospital San Cecilio, Granada, Spain.
- Subjects
Trabajo de parto ,Aging ,Glutatión peroxidasa ,Physiology ,Edad gestacional ,medicine.disease_cause ,Biochemistry ,Umbilical cord ,Umbilical vein ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] ,Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Tumor Necrosis Factors::Tumor Necrosis Factor-alpha [Medical Subject Headings] ,Named Groups::Persons::Parents::Mothers [Medical Subject Headings] ,Pregnancy ,Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative Stress [Medical Subject Headings] ,Catalasa ,Labor, Obstetric ,lcsh:Cytology ,Femenino ,Estrés oxidativo ,General Medicine ,Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Superoxide Dismutase [Medical Subject Headings] ,Catalase ,Fetal Blood ,Sangre fetal ,Superóxido dismutasa ,Humanos ,Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Peroxidases::Glutathione Peroxidase [Medical Subject Headings] ,medicine.anatomical_structure ,Gestation ,Female ,Artery ,Signal Transduction ,Research Article ,Adult ,Article Subject ,Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancy::Labor, Obstetric [Medical Subject Headings] ,Mothers ,Gestational Age ,Dinoprostona ,Named Groups::Persons::Age Groups::Infant::Infant, Newborn [Medical Subject Headings] ,Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Cytokines::Interleukins::Interleukin-6 [Medical Subject Headings] ,Chemicals and Drugs::Biological Factors::Inflammation Mediators::Autacoids::Eicosanoids::Prostaglandins::Prostaglandins E::Dinoprostone [Medical Subject Headings] ,Dinoprostone ,Interleucina-6 ,Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Gestational Age [Medical Subject Headings] ,Proinflammatory cytokine ,Anatomy::Fluids and Secretions::Body Fluids::Blood::Fetal Blood [Medical Subject Headings] ,Recién nacido ,medicine ,Humans ,lcsh:QH573-671 ,Fetus ,Glutathione Peroxidase ,business.industry ,Interleukin-6 ,Superoxide Dismutase ,Tumor Necrosis Factor-alpha ,Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Signal Transduction [Medical Subject Headings] ,Infant, Newborn ,Cell Biology ,medicine.disease ,Factor de necrosis tumoral alfa ,Oxidative Stress ,Check Tags::Female [Medical Subject Headings] ,Transducción de señal ,Immunology ,Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Peroxidases::Catalase [Medical Subject Headings] ,Madres ,business ,Oxidative stress - Abstract
The objective of the current study was to investigate for the first time and simultaneously the oxidative stress and inflammatory signaling induced during the delivery in healthy mothers and their neonates. 56 mothers with normal gestational course and spontaneous delivery were selected. Blood samples were taken from mother (before and after delivery) both from vein and artery of umbilical cord. Lower antioxidant enzymes activities were observed in neonates compared with their mothers and lower oxidative stress in umbilical cord artery with respect to vein. There was an overexpression of inflammatory cytokines in the mother, such as IL-6 and TNF-α, and, in addition, PGE2was also increased. Neonates showed lower levels of IL-6 and TNF-αand higher values of sTNF-RII and PGE2in comparison with their mothers. Parturition increases oxidative damage in the mother, although the indicators of oxidative damage were lower in umbilical cord artery with respect to umbilical vein. The overexpression of inflammatory cytokines reveals that fetus suffers its own inflammatory process during parturition.
- Published
- 2015
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