1. Tuning into miRNAs: A comprehensive analysis of their impact on diagnosis, and progression in asthma.
- Author
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Elrebehy MA, Abulsoud AI, El-Dakroury WA, Abdel Mageed SS, Elshaer SS, Fathi D, Rizk NI, Moustafa YM, Elballal MS, Mohammed OA, Abdel-Reheim MA, Zaki MB, Mahmoud AMA, Rashad AA, Sawan ES, Al-Noshokaty TM, Saber S, and Doghish AS
- Subjects
- Humans, Epigenesis, Genetic, Quality of Life, Biomarkers, MicroRNAs genetics, MicroRNAs therapeutic use, Asthma diagnosis, Asthma genetics, Asthma drug therapy
- Abstract
Asthma is a diverse inflammatory illness affecting the respiratory passages, leading to breathing challenges, bouts of coughing and wheezing, and, in severe instances, significant deterioration in quality of life. Epigenetic regulation, which involves the control of gene expression through processes such as post-transcriptional modulation of microRNAs (miRNAs), plays a role in the evolution of various asthma subtypes. In immune-mediated diseases, miRNAs play a regulatory role in the behavior of cells that form the airway structure and those responsible for defense mechanisms in the bronchi and lungs. They control various cellular processes such as survival, growth, proliferation, and the production of chemokines and immune mediators. miRNAs possess chemical and biological characteristics that qualify them as suitable biomarkers for diseases. They allow for the categorization of patients to optimize drug selection, thus streamlining clinical management and decreasing both the economic burden and the necessity for critical care related to the disease. This study provides a concise overview of the functions of miRNAs in asthma and elucidates their regulatory effects on the underlying processes of the disease. We provide a detailed account of the present status of miRNAs as biomarkers for categorizing asthma, identifying specific asthma subtypes, and selecting appropriate treatment options., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier GmbH. All rights reserved.)
- Published
- 2024
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