1. Anti-inflammatory and immunosuppressive compounds from Tripterygium wilfordii
- Author
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Ma, Jun, Dey, Moul, Yang, Hui, Poulev, Alexander, Pouleva, Reneta, Dorn, Ruth, Lipsky, Peter E., Kennelly, Edward J., and Raskin, Ilya
- Subjects
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TETRAHYDROFURAN , *IMMUNOREGULATION , *DNA polymerases , *POLYMERASE chain reaction - Abstract
Abstract: The extract of Tripterygium wilfordii Hook F. (TwHF), which showed anti-inflammatory and immunosuppressive activities in human clinical trials for rheumatoid arthritis, was subjected to the activity-guided fractionation and spectroscopic characterization of bioactives. A tetrahydrofuran lignan, tripterygiol (1), and eight known compounds, all capable of suppressing pro-inflammatory gene expression were identified. Most of the pharmacological activity of the extract can be attributed to triptolide, its most abundant and active component, with some contribution from tripdiolide. [Copyright &y& Elsevier]
- Published
- 2007
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