1. Inflammatory Bowel Disease: How Effective Is TNF-α Suppression?
- Author
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Lo, Wing-Cheong, Arsenescu, Violeta, Arsenescu, Razvan I., and Friedman, Avner
- Subjects
INFLAMMATORY bowel diseases ,CROHN'S disease ,TUMOR necrosis factors ,CYTOKINES ,IMMUNOSUPPRESSION ,T helper cells - Abstract
Crohn’s Disease (CD) results from inappropriate response toward commensal flora. Earlier studies described CD as a Th1 mediated disease. Current models view both phenotypes as a continuum of various permutations between Th1, Th2 and Th17 pathways compounded by a range of Treg disfunctions. In the present paper, we develop a mathematical model, by a system of differential equations, which describe the dynamic relations among these T cells and their cytokines. The model identities four groups of CD patients according to up/down regulation of Th1 and Th2. The model simulations show that immunosuppression by TNF-α blockage benefits the group with Th1
High /Th2Low while, by contrast, the group with Th1Low /Th2High will benefit from immune activation. [ABSTRACT FROM AUTHOR]- Published
- 2016
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