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Start Over Author "Carrie Hayes" Journal proceedings of the national academy of sciences of the united states of america
4 results on '"Carrie Hayes"'

3. Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations

Author

Gregg L. Semenza, Erik Laughner, and Carrie Hayes Sutter

Subjects
Hypoxia-Inducible Factor 1, Macromolecular Substances, Mutation, Missense, Biology, Transfection, Cell Line, Missense mutation, Humans, Point Mutation, Nuclear protein, Transcription factor, Ubiquitins, Sequence Deletion, Regulation of gene expression, Cell Nucleus, Multidisciplinary, Point mutation, Helix-Loop-Helix Motifs, Nuclear Proteins, Hypoxia-Inducible Factor 1, alpha Subunit, Molecular biology, Recombinant Proteins, DNA-Binding Proteins, Oxygen, Hypoxia-inducible factors, Gene Expression Regulation, Mutagenesis, Site-Directed, Erythropoiesis, Protein Processing, Post-Translational, Transcription Factors
Abstract

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediates cellular and systemic homeostatic responses to reduced O 2 availability in mammals, including angiogenesis, erythropoiesis, and glycolysis. HIF-1 activity is controlled by the O 2 -regulated expression of the HIF-1α subunit. Under nonhypoxic conditions, HIF-1α protein is subject to ubiquitination and proteasomal degradation. Here we report that missense mutations and/or deletions involving several different regions of HIF-1α result in constitutive expression and transcriptional activity in nonhypoxic cells. We demonstrate that hypoxia results in decreased ubiquitination of HIF-1α and that missense mutations increase HIF-1α expression under nonhypoxic conditions by blocking ubiquitination.

Published
2000

4. Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations.

Author

Sutter, Carrie Hayes and Laughner, Erik

Subjects
*HYPOXEMIA, *GENETIC mutation
Abstract

Features a study which reported that missense mutations and/or deletions involving several regions of hypoxia-inducible factor 1 (HIF-1) results in constitutive expression and transcriptional activity in nonhypoxic cells. Role of oxygen-regulated ubiquitination on HIF-1alpha protein expression; Methodology of the study; Results and discussion; Conclusion.

Published
2000
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