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Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the relationship between serum clusterin (CLU) and granule membrane protein 140 (GMP140) and coronary artery lesions and major adverse cardiovascular events (MACE) in patients with acute myocardial infarction (AMI). Methods: 129 patients with AMI who were admitted to our hospital from January 2020 to December 2021 were selected as the AMI group. According to the number of coronary artery lesions, they were divided into single vessel lesion group (n=34), double vessel lesion group (n=50), and multi vessel lesion group (n=45). The patients were followed up for 6 months and divided into MACE group and non-MACE group according to whether MACE occurred. Another 55 healthy volunteers in the same period were selected as the control group. The clinical data of patients with AMI were collected, and the serum CLU and GMP140 levels were detected by enzyme-linked immunosorbent assay. Multivariate Logistic regression was used to analyze the influencing factors of MACE in patients with AMI, and the predictive value of serum CLU and GMP140 levels on MACE in patients with AMI was analyzed by the receiver operating characteristic (ROC) curve. Results: Serum CLU and GMP140 levels in the AMI group were higher than those in the control group (P<0.05). The serum CLU and GMP140 levels in the single vessel disease group, double vessel disease group and multi vessel disease group increased in turn (P<0.05). 6 months after follow-up, the incidence of MACE in 129 patients with AMI was 25.58% (33/129). Multivariate Logistic regression analysis showed that elevated left ventricular ejection fraction was independent protective factor, increased age, ST segment elevation myocardial infarction, KILLIP grade≥III, elevated low density lipoprotein cholesterol (LDL-C), elevated CLU and elevated GMP140 were independent risk factors for MACE in patients with AMI (P<0.05). ROC curve analysis showed that the area under curve of MACE predicted by serum CLU and GMP140 levels in patients with AMI was greater than that predicted by CLU and GMP140 alone (P<0.05). Conclusion: Elevated serum CLU and GMP 140 levels in patients with AMI are associated with coronary artery lesions and MACE, and which may be an auxiliary predictor of MACE in patients with AMI. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

To investigate the effect of probiotics combined with triple therapy on ( ) - related gastritis in children and its influence on inflammatory factors. 93 cases of related gastritis in our hospital from January 2017 to June 2018 were selected, and they were divided into study group (n=47) and control group (n=46) according to the method of random number table. The control group was treated with triple therapy. The study group was treated with probiotics on the basis of the control group, the clinical effect, total score of clinical symptoms, inflammatory factors, HP eradication rate, incidence and recurrence of adverse reactions were compared. After 1 month treatment, the total clinical effective rate of the study group was 87.23% (41/47), which was higher than 69.57% (32/46) of the control group (P<0.05). The total score of clinical symptoms after 2 weeks and 1 month treatment and the levels of serum tumor necrosis factor-α (TNF-α), hypersensitive c-reactive protein (hs-CRP), interleukin-6 (IL-6) after 1 month treatment of the two groups decreased (P<0.05), and those of the study group were lower than those of the control group (P<0.05). The eradication rate of HP of the study group was higher than that of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions and recurrence rate between the two groups (P>0.05). The curative effect of probiotics combined with triple therapy in the treatment of HP related gastritis in children is definite, which can improve the clinical symptoms and reduce the level of inflammatory factors with good drug safety in children. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

With the help of information visualization tools, this paper makes a visual analysis of the relevant literatures in the field of TCM talent cultivation collected by CNKI (China Knowledge Resource Base) based on the sample data of the documents published during the construction time of China KnowledgeNet-December 31, 2017, and analyses the composition of the research subjects of TCM talent cultivation by drawing up the distribution of the authors, institutions and funds of the literatures. Key words co-occurrence atlas and word frequency and centrality are used to analyze the research topics and hotspots of TCM personnel training in China. The purpose is to show the current situation, research hotspots and future research trends of TCM personnel training in China intuitively, so as to identify and explore the basic trend and overall development context of TCM personnel training in China. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the effects of 5-bromodeoxyuiidine (BrdU) tracing in vivo on the biological stams of bone marrow stromal stem cells(BMSCs). Methods: Healthy adult beagle dog bone marrow was extracted, then cultured and indentified by BrdU markers, the cell cycle, apoptosis rate, cell viability were determined in vitro. The stem cells were given implantation of autogenous femoral head defect by BMSCs labeled BrdU in vivo, the other side were given implantation of autogenous bone as the control, the bone mass and molecular markers expression were recorded. Results: The BrdU labeling rate of BMSCs in vitro was 85.2%. The apoptosis rate of BrdU group was 3.62± 1.33%, the unlabeled group was 3.52± 1.08%. The cell survival rate of BrdU group and unlabeled group were 96.31± 1.39% and 95.20± 2.10%(P>0.05). knmuiioliistochemical staining of BrdU labeled BMSCs showed positive BrdU staining, the positive rate was 81.6%. The expression quantity and the intensity of osteocalcin and collagen in the transplantation bone side were higher than those of the control side. The bone mass in the transplantation bone side was 17.46± 2.12%, which was 9.06± 1.24% in the control (P<0.05). Conclusion: BrdU labeled BMSCs could effectively reflect the biological state of cells in vitro, it showed that the BMSCs transplantation could survive hi vivo, it could promote the bone formation and repair of necrotic bone. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the influence of shenling baizhu powder on the immune function and clinical effect of elderly patients with colitis gravis and bloody purulent stool. Methods: 50 elderly patients with colitis gravis and bloody purulent stool who were treated in our hospital were selected and randomly divided into the experimental group and control group with 25 cases in each group, patients in the control group were treated with sulfasalazine colonosoluble capsules, patients in the experimental group were treated on the base of the control group with shenling baizhu powder, patients in both groups of were treated for 3 months, the serum intedeukin 2 (IL-2), γ-interferon (IFN-γ) and interleukin 10 (IL-10) levels of both groups were compared before and after treatment, and the clinical efficacy of the two groups of patients were evaluated. Results: Compared with before treatment, the serum IL-2, IFN-γ IL-10 levels of both groups were obviously decreased after treatment; compared with the control group, the serum IL-2, IFN-γ and IL-10 levels of experimental group were significantly lower (P<0.05); and compared with the control group, the total clinical effective rote of experimental group was higher (P<0.05). Conclusion: Shenling baizhu powder could effectively improve the immune function and clinical effect of elderly patients with colitis gravis and bloody purulent stool. [ABSTRACT FROM AUTHOR]

Objective: To forecast and verify the target genes of miRNA-194 in human osteosarcoma and establish some theoretical basis for osteosarcoma treatment and element experience of miRNA-194 for further research. Methods: Potential target gene of miRNA-194 was predicted using bioinformatics and were verified in gene and protein levels. Moreover, luciferase reporter assay was used to confirm whether CDH2 was direct targets of miRNA-194. Results: Potential target genes of miRNA-194 were predicted by using bioinformatics. Moreover, luciferase activity of the wild-type PTEN-3'-UTR reporter was significantly suppressed in miRNA-194up-regulation group compared with other groups in SOSP-9607 cells(P<0.01) while down-regulation group could significantly increase it(P<0.01). At the same time, western blot analysis revealed that miRNA-194 expression could affect the expression of CDH2 protein while there was no significant difference on m RNA level(P<0.05). Conclusion: CDH2, one target gene of miRNA-194, was predicted and verified, which provided the theoretical basis for the next study of miRNA-194 in the osteosarcoma. [ABSTRACT FROM AUTHOR]

Objective: We examined the effects of miRNA-194 on the capacities of tumor formation and pulmonary metastasis of osteosarcoma in nude mice by using recombinant lentiviruses. All these wouLd provide the foundation of theory to explore microRNA- 194 as a new target of osteosarcoma therapy. Methods: we transfected human osteosarcoma cell lines U2-OS by using recombinant lentiviruses and divided the mice into three groups. Then we put the cells into the mice to built the metastasis model of rude mice. 5 weeks later the mice were killed to compare the size and weight of tumor in leg and lung. Results: 1) The size and weight of miRNA- 194-down were obviously higher than that in other groups (P<0.05). 2) The lung of rude mice of miRNA-194-up cell were obviously better than that in other groups(P<0.05). 3) It were certified that the tumor were osteosarcoma and metastatic tumor. Conclusion: In vivo, miRNA-194 couLd significantly inhibit the capacities of tumor formation and pulmonary metastasis which declare that miRNA-194 may play the role of tumor suppressor genes in osteosarcoma, which provide a good foundation for the study of miRNA-194. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

SIRT1 is a nicotinamide adenine dinucleotide NAD-dependent deacetylase which can remove the acetyl group of various proteins and be homologous with Yeast SIR2. The capacity of SIRT1 is to execute and coordinate variety biological functions,which is very important for organisms existing in vivo. This paper focuses on the biological mechanism of SIRT1 in aging, cancer,metabolism-disording diseases in order to explore the signficance of SIRT1. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Coronary artery disease is one of the most fatal diseases all over the world, of which, acute coronary syndrome (ACS) is the most pernicious. 70% of acute cardiac events are not caused by serious stenosis, but by acute stenosis followed by rupture of vulnerable plaque and thrombus afertwards. The vulnerable plaque of coronary artery plays the major role in the onset of acute coronary syndrome, so, it should be early diagnosed and intervened positively. With the technological progress, CT, MRI, intravascular unltrasound (IVUS) and optical coherence tomography (OCT) have been successfully used to evaluate the vulnerable plaque. Molecular imaging can reveal molecular mechanism of the coronary plaque and discover the plaque at even earlier stage. So, it is of great importance to make clear the advantages and disadvantages of all the methods and the research hotspots in the medical imaging field. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)