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Start Over Author "Franck, Nicolas" Journal psychiatry research
12 results on '"Franck, Nicolas"'

12. Neural correlates of action attribution in schizophrenia.

Author

Farrer C, Franck N, Frith CD, Decety J, Georgieff N, d'Amato T, and Jeannerod M

Subjects
Adult, Brain diagnostic imaging, Brain Mapping, Cerebral Cortex diagnostic imaging, Cerebral Cortex physiopathology, Delusions diagnostic imaging, Delusions psychology, Gyrus Cinguli diagnostic imaging, Gyrus Cinguli physiopathology, Humans, Male, Nerve Net diagnostic imaging, Nerve Net physiopathology, Neural Analyzers diagnostic imaging, Neural Analyzers physiopathology, Schizophrenia diagnostic imaging, Brain physiopathology, Delusions physiopathology, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Internal-External Control, Perceptual Distortion physiology, Psychomotor Performance physiology, Schizophrenia physiopathology, Schizophrenic Psychology, Tomography, Emission-Computed, Single-Photon, User-Computer Interface
Abstract

Patients with first-rank symptoms (FRS) of schizophrenia do not experience all of their actions and personal states as their own. FRS may be associated with an impaired ability to correctly attribute an action to its origin. In the present study, we examined regional cerebral blood flow (rCBF) with positron emission tomography during an action-attribution task in a group of patients with FRS. We used a device previously used with healthy subjects that allows the experimenter to modulate the subject's degree of movement control (and thus action attribution) of a virtual hand presented on a screen. In healthy subjects, the activity of the right angular gyrus and the insula cortex appeared to be modulated by the subject's degree of movement control of the virtual hand. In the present study, the schizophrenic patients did not show this pattern. We found an aberrant relationship between the subject's degree of control of the movements and rCBF in the right angular gyrus and no modulation in the insular cortex. The implications of these results for understanding pathological conditions such as schizophrenia are discussed.

Published
2004
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