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Purpose and Background: A feasibility study is performed to evaluate the possibility of using the transit dose of portal images on the beam axis to measure the accuracy in dose delivery. The algorithm and the method are tested on a breast phantom and on patients with a breast disease., Materials and Methods: To estimate the transit dose at various air gaps behind the patient, a method is proposed which applies, for a given air gap, the inverse square law to the primary component of the exit dose and an experimentally determined function for the scatter component of the exit dose. It is assumed that the primary component and the scattered component of the exit dose are given by the treatment planning system. The experimental function for the variation of the scattered component with the air gap, determined by phantom measurements, is modelled by an analytical function which contains only field size, air gap and one energy-dependent parameter., Results: The measurements on the breast phantom yield a maximum deviation between measured and estimated transit doses of 4.5%. The mean deviation is 0.9% with a standard deviation of the distribution of 2.3%. In vivo diode measurements on the same phantom yield a maximum deviation of 2.7%. Transit dose measurements on the beam axis for 45 portal images of breast patients show a mean deviation of 0.0% between the measured transit dose and the estimated transit dose. The standard deviation of the distribution is 4.4%. The method seems to be very sensitive to patient positioning and to discrepancies in breast thicknesses used for treatment planning., Conclusion: Preliminary results on breast patients show that the method proposed to evaluate transit doses on the beam axis from portal images may be a valuable alternative to conventional in vivo exit dosimetry. The method can be implemented in a simple way and does not require additional time during the irradiation session, as exit dosimetry with diodes does. The transit dose is only considered in one point. Nevertheless, in the framework of quality assurance of treatment delivery, this study is an example of the possibilities of monitoring at the same time the visual evaluation of the irradiated volume as well as the dosimetric control (i.e. in Gy) of treatment delivery with portal images.

Background and Purpose: This paper describes the technology and methods involved in a system for automatically checking the position of patients at radiotherapy units. This is proposed for improving the accuracy in the irradiation geometrical set-up, which is a crucial factor in radiotherapy quality control., Materials and Methods: The system is based on real-time opto-electronics and close-range photogrammetry and detects multiple passive markers placed on selected patient skin landmarks. Patient alignment and position monitoring is carried out by comparing the current three-dimensional positions of the markers with those of an initial reference position acquired during the simulation procedure and/or the first irradiation session. The system was used to measure the accuracy of conventional laser centering techniques for patient repositioning. Inaccuracies due to breathing and random movements were also taken into account. Professional technicians were asked to reposition three volunteer subjects carefully using a traditional laser centering procedure., Results: The results revealed significant repositioning errors even in highly controlled conditions, affecting particularly body areas relatively far from the skin reference points used for laser alignment., Conclusions: The outcome of the experimental application of this technology confirms its potential as a tool for patient repositioning and automatic detection of any errors caused by breathing or other unpredictable movements. The real-time feedback on the patient's position given by the system provides operators with appropriate visual indices and allows them to take suitable countermeasures in case of significant failures. In addition, the use of the system output for automatic position control is envisaged.

Background and Purpose: Since 1969 the International Atomic Energy Agency (IAEA), together with the World Health Organization (WHO), has performed postal TLD audits to verify the calibration of radiotherapy beams in developing countries., Materials and Methods: A number of changes have recently been implemented to improve the efficiency of the IAEA/WHO TLD programme. The IAEA has increased the number of participants and reduced significantly the total turn-around time to provide results to the hospitals within the shortest possible time following the TLD irradiations. The IAEA has established a regular follow-up programme for hospitals with results outside acceptance limits of +/- 5%., Results: The IAEA has, over 30 years, verified the calibration of more than 3300 clinical photon beams at approximately 1000 radiotherapy hospitals. Only 65% of those hospitals who receive TLDs for the first time have results within the acceptance limits, while more than 80% of the users that have benefited from a previous TLD audit are successful. The experience of the IAEA in TLD audits has been transferred to the national level. The IAEA offers a standardized TLD methodology, provides guidelines and gives technical back-up to the national TLD networks., Conclusion: The unsatisfactory status of the dosimetry for radiotherapy, as noted in the past, is gradually improving; however, the dosimetry practices in many hospitals in developing countries need to be revised in order to reach adequate conformity to hospitals that perform modern radiotherapy in Europe, USA and Australia.

Background and Purpose: In view of using portal images for exit dosimetry, an experimental study is performed of relative transit dose profiles at different distances behind patients (and phantoms) and of their relation to the exit dose profile., Materials and Methods: Irregular, homogeneous polystyrene phantoms with a variable thickness to simulate head and neck (H&N) treatments (6-MV photon beam) are investigated by ionization chamber measurements performed close to the exit surface and at various distances behind the phantom (10, 20 and 30 cm). Similar measurements are performed for a rectangular phantom with large inhomogeneities (A1 and air). For one irregular homogeneous phantom and an irregular phantom containing an A1 inhomogeneity, ionization chamber measurements are performed at the exit surface, and a portal film image is taken at 30 cm behind the phantom. Portal films of a patient treated for a head and neck malignancy are evaluated for different air gaps behind the patient., Results: For the irregular phantoms, deviations up to 15% and more are observed between the exit dose profile (along the shaped surface of the phantom) and the transit profile close to the phantom (perpendicular to the beam axis). There is, however, a good agreement--within 3%--between the exit profile and the transit profile at 30 cm. For the rectangular, inhomogeneous phantom, the deviation between the exit profile and the transit dose profile at 30 cm does not exceed 5%; transit dose profiles overestimate the exit dose for the air cavity and underestimate the dose for the A1 inhomogeneity. Measurements on portal films of a H&N patient for different air gaps confirm the order of magnitude of the difference observed between transit dose profiles close to the patient and transit dose profiles at some distance behind the patient., Conclusions: For 6-MV photon beam treatments with significant thickness variations (H&N), large variations (> 10%) are observed in transit dose profiles as a function of the air gap between the patient and the portal film. For this energy, a good agreement is found between the exit profile and the transit profile at about 30 cm behind the patient.

Purpose: In vivo dosimetry has been shown in a number of evaluation studies, generally carried out in larger academic centres, to be a reliable method of checking the overall treatment accuracy. The object of this study was to investigate whether it was possible and useful to perform in vivo dosimetry in a small radiotherapy department and to detect if there were any systematic errors in the overall treatment set-up., Materials and Methods: All patients were treated on a cobalt-60 unit equipped with a verification system. Six hundred fifty entrance dose measurements were performed with silicon diodes., Results: The analysis showed a mean deviation of -1.3%. This negative deviation was mainly due to the mean deviation obtained in the treatment of head and neck (-1.6%) or breast (-2.5%) cancer patients. The results for pelvic or lung irradiation showed almost no deviation (-0.8 to 0.43%). Further investigation showed that the negative values for head and neck or breast irradiation were due to the irradiation technique; the lack of scattering material causes a reduction of the dose at the reference point, which is not taken into consideration by the treatment planning system. By performing in vivo dosimetry, we were also able to detect two large errors in 650 measurements and could prevent erroneous treatment., Conclusion: Even when the overall treatment set-up is very accurate, in vivo dosimetry is very useful in a small department since only a small effort can detect and prevent errors.

Variation in the table height position for 175 treatments of 167 patients was calculated as a measure for day-to-day set-up precision in 2063 treatment sessions and resulted in a median standard deviation of 1 mm. The median standard deviations of table longitudinal and lateral position were 3 and 5 mm, respectively.

Our facility has added high-technology ancillary devices to our dual-energy linear accelerator. After commissioning and acceptance testing of dual asymmetric jaws, dynamic wedge, portal imaging, and multileaf collimation (MLC), quality assurance programs were instituted. The programs were designed to be both periodic and patient specific when required. In addition, when dosimetric aspects were affected by these technologies, additional quality assurance checks were added. Positional accuracy checks (light and radiation) are done for both asymmetric jaws and MLC. Each patient MLC field is checked against the original simulation or digitally reconstructed radiographs. Off-axis factors and output checks are performed for asymmetric fields. Dynamic wedge transmission factors and profiles are checked periodically, and a patient diode check is performed for every new dynamic wedge portal. On-line imaging checks encompass safety checks along with periodic measurement of contrast and spatial resolution. The most important quality assurance activity is the annual review of proper operation and procedures for each device. Our programs have been successful in avoiding patient-related errors or device malfunctions. The programs are a team effort involving physicists, maintenance engineers, and therapists.

Due to the large number of steps and the number of persons involved in the preparation of a radiation treatment, the transfer of information from one step to the next is a very critical point. Errors due to inadequate transfer of information will be reflected in every next step and can seriously affect the final result of the treatment. We studied the frequency and the sources of the transfer errors. A total number of 464 new treatments has been checked over a period of 9 months (January to October 1990). Erroneous data transfer has been detected in 139/24,128 (less than 1%) of the transferred parameters; they affected 26% (119/464) of the checked treatments. Twenty-five of these deviations could have led to large geographical miss or important over- or underdosage (much more than 5%) of the organs in the irradiated volume, thus increasing the complications or decreasing the tumour control probability, if not corrected. Such major deviations, only occurring in 0.1% of the transferred parameters, affected 5% (25/464) of the new treatments. The sources of these large deviations were nearly always human mistakes, whereas a considerable number of the smaller deviations were, in fact, consciously taken decisions to deviate from the intended treatment. Nearly half of the major deviations were introduced during input of the data in the check-and-confirm system, demonstrating that a system aimed to prevent accidental errors, can lead to a considerable number of systematic errors if used as an uncontrolled set-up system. The results of this study show that human mistakes can seriously affect the outcome of patient treatments.(ABSTRACT TRUNCATED AT 250 WORDS)

Entrance dose measurements were performed with semiconductor detectors on patients treated for head and neck and brain tumors with a 6 MV X-ray beam. A total number of 554 treatment set-ups were measured. The results showed a gaussian distribution with a mean value of 97.8% and a standard deviation of 2.8%. A systematic error of 2.2% on the mean value was shown to be due to a systematic deficiency in the algorithm used in the planning system and to a systematic error in the application of the dosimetry protocol. Two treatment techniques were identified leading to an erroneous dose delivery. Finally, large deviations (more than 2 S.D.) of the measured dose from the expected dose were detected in 3% of the measured treatment set-ups, the sources of the errors could in all cases be identified and eliminated in the further treatment sessions. This study demonstrated the reliability of the use of semiconductor detectors for in vivo dosimetry and its usefulness as part of a departmental quality assurance program.