1. The interferon-induced MxB protein inhibits an early step of HIV-1 infection
- Author
-
Fengwen Xu, Jin Qian, Chen Liang, Shan Cen, Shilei Ding, Zhenlong Liu, Fei Guo, Jinming Zhou, and Qinghua Pan
- Subjects
biology ,business.industry ,RNA ,Virology ,Virus ,chemistry.chemical_compound ,Infectious Diseases ,Protein structure ,chemistry ,Interferon ,Poster Presentation ,biology.protein ,Medicine ,Antibody ,business ,Gene ,DNA ,Function (biology) ,medicine.drug - Abstract
Background Interferon protects cells from virus infection by inducing the expression of genes with antiviral activities. One such antiviral gene is Mx (myxovirus resistance) that was first identified in mice for its protection against influenza virus infection. Humans carry two Mx genes, MxA and MxB. Although MxA has been reported to inhibit a number of RNA and DNA viruses, the antiviral function of MxB has just begun to be revealed.
- Published
- 2013