1. KLF5 promotes cervical cancer proliferation, migration and invasion in a manner partly dependent on TNFRSF11a expression
- Author
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Huan-Yu Zheng, Ou Li, Lu Yuan, Shan Zhao, Ling-Ya Chang, Xin-Yue Wang, Yanjie Xiong, Jun-Jian Zhao, Dong Ma, Mei-Li Geng, Qi Zhang, and Fu-Yuan Cao
- Subjects
0301 basic medicine ,Kruppel-Like Transcription Factors ,lcsh:Medicine ,Uterine Cervical Neoplasms ,Inflammation ,Mice, SCID ,Biology ,medicine.disease_cause ,p38 Mitogen-Activated Protein Kinases ,Article ,03 medical and health sciences ,0302 clinical medicine ,Cell Movement ,Cell Line, Tumor ,medicine ,Animals ,Humans ,Neoplasm Invasiveness ,Receptor ,lcsh:Science ,Promoter Regions, Genetic ,Transcription factor ,Cell Proliferation ,Multidisciplinary ,Receptor Activator of Nuclear Factor-kappa B ,Cell growth ,Tumor Necrosis Factor-alpha ,lcsh:R ,Cancer ,Middle Aged ,medicine.disease ,Survival Analysis ,Hedgehog signaling pathway ,Gene Expression Regulation, Neoplastic ,030104 developmental biology ,030220 oncology & carcinogenesis ,Cancer research ,Carcinoma, Squamous Cell ,Tumor necrosis factor alpha ,lcsh:Q ,Female ,medicine.symptom ,Carcinogenesis ,Protein Binding - Abstract
Although the transcription factor Krüppel-like factor 5 (KLF5) plays important roles in both inflammation and cancer, the mechanism by which this factor promotes cervical carcinogenesis remains unclear. In this study, we demonstrated a potential role for tumour necrosis factor receptor superfamily member 11a (TNFRSF11a), the corresponding gene of which is a direct binding target of KLF5, in tumour cell proliferation and invasiveness. Coexpression of KLF5 and TNFRSF11a correlated significantly with tumorigenesis in cervical tissues (P in vivo functional TNFRSF11a-knockdown mouse studies revealed suppression of tumorigenicity and liver metastatic potential. Notably, tumour necrosis factor (TNF)-α induced KLF5 expression by activating the p38 signalling pathway and high KLF5 and TNFRSF11a expression increased the risk of death in patients with cervical squamous cell carcinoma. Our results demonstrate that KLF5 and TNFRSF11a promote cervical cancer cell proliferation, migration and invasiveness.
- Published
- 2017