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5. Genetic susceptibility variants for lung cancer: replication study and assessment as expression quantitative trait loci

Author

Pintarelli, Giulia, primary, Cotroneo, Chiara Elisabetta, additional, Noci, Sara, additional, Dugo, Matteo, additional, Galvan, Antonella, additional, Delli Carpini, Simona, additional, Citterio, Lorena, additional, Manunta, Paolo, additional, Incarbone, Matteo, additional, Tosi, Davide, additional, Santambrogio, Luigi, additional, Dragani, Tommaso A., additional, and Colombo, Francesca, additional

Published
2017
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6. Genetic susceptibility variants for lung cancer: replication study and assessment as expression quantitative trait loci

Author

Lorena Citterio, Matteo Dugo, Chiara E. Cotroneo, Tommaso A. Dragani, Paolo Manunta, Matteo Incarbone, Francesca Colombo, Luigi Santambrogio, Simona Delli Carpini, Giulia Pintarelli, Antonella Galvan, Davide Tosi, Sara Noci, Pintarelli, Giulia, Cotroneo, Chiara Elisabetta, Noci, Sara, Dugo, Matteo, Galvan, Antonella, Delli Carpini, Simona, Citterio, Lorena, Manunta, Paolo, Incarbone, Matteo, Tosi, Davide, Santambrogio, Luigi, Dragani, Tommaso A, and Colombo, Francesca

Subjects
Adult, Male, 0301 basic medicine, Proteasome Endopeptidase Complex, Lung Neoplasms, Quantitative Trait Loci, SNP, Adenocarcinoma of Lung, Single-nucleotide polymorphism, Adenocarcinoma, Biology, Polymorphism, Single Nucleotide, survival, Article, 03 medical and health sciences, 0302 clinical medicine, lung adenocarcinoma risk, medicine, Genetic predisposition, Humans, Genetic Predisposition to Disease, Allele, Lung cancer, Iron Regulatory Protein 2, Gene, Aged, Aged, 80 and over, Genetics, Multidisciplinary, Middle Aged, Endonucleases, medicine.disease, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, 030104 developmental biology, 030220 oncology & carcinogenesis, Expression quantitative trait loci, differential allelic expression, Female, ERCC1, Genome-Wide Association Study
Abstract

Many single nucleotide polymorphisms (SNPs) have been associated with lung cancer but lack confirmation and functional characterization. We retested the association of 56 candidate SNPs with lung adenocarcinoma risk and overall survival in a cohort of 823 Italian patients and 779 healthy controls, and assessed their function as expression quantitative trait loci (eQTLs). In the replication study, eight SNPs (rs401681, rs3019885, rs732765, rs2568494, rs16969968, rs6495309, rs11634351, and rs4105144) associated with lung adenocarcinoma risk and three (rs9557635, rs4105144, and rs735482) associated with survival. Five of these SNPs acted as cis-eQTLs, being associated with the transcription of IREB2 (rs2568494, rs16969968, rs11634351, rs6495309), PSMA4 (rs6495309) and ERCC1 (rs735482), out of 10,821 genes analyzed in lung. For these three genes, we obtained experimental evidence of differential allelic expression in lung tissue, pointing to the existence of in-cis genomic variants that regulate their transcription. These results suggest that these SNPs exert their effects on cancer risk/outcome through the modulation of mRNA levels of their target genes.

Published
2017

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