17 results on '"Tao, Xia"'
Search Results
2. A model-based analysis of phenytoin and carbamazepine toxicity treatment using binding-competition during hemodialysis
- Author
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Maheshwari, Vaibhav, Hoffman, Robert S., Thijssen, Stephan, Tao, Xia, Fuertinger, Doris H., and Kotanko, Peter
- Published
- 2020
- Full Text
- View/download PDF
3. Identification of a Flavonoid Glucosyltransferase Involved in 7-OH Site Glycosylation in Tea plants (Camellia sinensis)
- Author
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Xinlong Dai, Juhua Zhuang, Yingling Wu, Peiqiang Wang, Guifu Zhao, Yajun Liu, Xiaolan Jiang, Liping Gao, and Tao Xia
- Subjects
Medicine ,Science - Abstract
Abstract Flavonol glycosides, which are often converted from aglycones in a process catalyzed by UDP-glycosyltransferases (UGTs), play an important role for the health of plants and animals. In the present study, a gene encoding a flavonoid 7-O-glycosyltransferase (CsUGT75L12) was identified in tea plants. Recombinant CsUGT75L12 protein displayed glycosyltransferase activity on the 7-OH position of multiple phenolic compounds. In relative comparison to wild-type seeds, the levels of flavonol-glucosides increased in Arabidopsis seeds overexpressing CsUGT75L12. In order to determine the key amino acid residues responsible for the catalytic activity of the protein, a series of site-directed mutagenesis and enzymatic assays were performed based on the 3D structural modeling and docking analyses. These results suggested that residue Q54 is a double binding site that functions as both a sugar receptor and donor. Residues H56 and T151, corresponding to the basic active residues H20 and D119 of VvGT1, were not irreplaceable for CsUGT75L12. In addition, residues Y182, S223, P238, T239, and F240 were demonstrated to be responsible for a ‘reversed’ sugar receptor binding model. The results of single and triple substitutions confirmed that the function of residues P238, T239, and F240 may substitute or compensate with each other for the flavonoid 7-O-glycosyltransferase activity.
- Published
- 2017
- Full Text
- View/download PDF
4. Enhancing the Oxidation of Toluene with External Electric Fields: a Reactive Molecular Dynamics Study
- Author
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Shen Tan, Tao Xia, Yao Shi, Jim Pfaendtner, Shuangliang Zhao, and Yi He
- Subjects
Medicine ,Science - Abstract
Abstract The effects of external electric field (Efield) on chemical reactions were studied with the reactive molecular dynamics (ReaxFF MD) simulations by using the oxidation of toluene as a model system. We observed that Efields may greatly enhance the oxidation rate of toluene. The initial reaction time of toluene is also reduced remarkably in Efields. A stronger Efield leads to a faster oxidation rate of toluene. Further studies reveal that the applying of a Efield may result in the oxidation of toluene at 2100 K which is otherwise not able to happen when the Efield is not present. The oxidation rate of toluene at 2100 K in a Efield is comparable with the oxidation rate of toluene at 2900 K when the Efield is not applied. In addition, Efields were observed to significantly enhance the occurrence of the initial radical generation for different pathways of toluene oxidation but they do not seem to favor any of the pathways. Finally, Efields do not seem to enhance the polarization of toluene during its transition state, which suggests that a polarizable charge equilibration method (PQEq) method might be needed to take the effects of Efields into consideration.
- Published
- 2017
- Full Text
- View/download PDF
5. Diagnostic value of plasma tryptophan and symmetric dimethylarginine levels for acute kidney injury among tacrolimus-treated kidney transplant patients by targeted metabolomics analysis
- Author
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Zhang, Feng, Wang, Qinghua, Xia, Tianyi, Fu, Shangxi, Tao, Xia, Wen, Yan, Chan, Shen’an, Gao, Shouhong, Xiong, Xiaojuan, and Chen, Wansheng
- Published
- 2018
- Full Text
- View/download PDF
6. The influence of spatial frequency content on facial expression processing: An ERP study using rapid serial visual presentation
- Author
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Jian Wang, Jinhua Tian, Tao Xia, Wenshuang Zhao, Qianru Xu, and Weiqi He
- Subjects
Male ,Adolescent ,Speech recognition ,Emotions ,Happiness ,lcsh:Medicine ,Facial recognition system ,Article ,050105 experimental psychology ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Emotion perception ,Reaction Time ,Humans ,0501 psychology and cognitive sciences ,lcsh:Science ,Facial expression ,Multidisciplinary ,05 social sciences ,lcsh:R ,Brain ,Fear ,Healthy Volunteers ,Facial Expression ,Rapid serial visual presentation ,Pattern Recognition, Visual ,Time course ,Pattern recognition (psychology) ,Female ,Low spatial frequency ,lcsh:Q ,Spatial frequency ,Psychology ,Facial Recognition ,030217 neurology & neurosurgery - Abstract
Spatial frequency (SF) contents have been shown to play an important role in emotion perception. This study employed event-related potentials (ERPs) to explore the time course of neural dynamics involved in the processing of facial expression conveying specific SF information. Participants completed a dual-target rapid serial visual presentation (RSVP) task, in which SF-filtered happy, fearful, and neutral faces were presented. The face-sensitive N170 component distinguished emotional (happy and fearful) faces from neutral faces in a low spatial frequency (LSF) condition, while only happy faces were distinguished from neutral faces in a high spatial frequency (HSF) condition. The later P3 component differentiated between the three types of emotional faces in both LSF and HSF conditions. Furthermore, LSF information elicited larger P1 amplitudes than did HSF information, while HSF information elicited larger N170 and P3 amplitudes than did LSF information. Taken together, these results suggest that emotion perception is selectively tuned to distinctive SF contents at different temporal processing stages.
- Published
- 2018
7. Isolation and Characterization of Key Genes that Promote Flavonoid Accumulation in Purple-leaf Tea (Camellia sinensis L.)
- Author
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Xingxing Shi, Yunsheng Wang, Tao Xia, Xuecheng Zhao, Liping Gao, Xiujuan He, Xinlong Dai, and Yajun Liu
- Subjects
0106 biological sciences ,0301 basic medicine ,Transgene ,Population ,Flavonoid ,Gene Expression ,lcsh:Medicine ,Genetically modified crops ,Biology ,Genes, Plant ,01 natural sciences ,Article ,Camellia sinensis ,03 medical and health sciences ,Flavonols ,Quantitative Trait, Heritable ,Cloning, Molecular ,education ,lcsh:Science ,Gene ,Transcription factor ,Chromatography, High Pressure Liquid ,Genetic Association Studies ,Phylogeny ,chemistry.chemical_classification ,Flavonoids ,education.field_of_study ,Multidisciplinary ,Tea ,Pigmentation ,Gene Expression Profiling ,Structural gene ,fungi ,lcsh:R ,Computational Biology ,food and beverages ,Plant Leaves ,030104 developmental biology ,Biochemistry ,chemistry ,lcsh:Q ,Transcriptome ,010606 plant biology & botany - Abstract
There were several high concentrations of flavonoid components in tea leaves that present health benefits. A novel purple-leaf tea variety, ‘Mooma1’, was obtained from the natural hybrid population of Longjing 43 variety. The buds and young leaves of ‘Mooma1’ were displayed in bright red. HPLC and LC-MS analysis showed that anthocyanins and O-Glycosylated flavonols were remarkably accumulated in the leaves of ‘Mooma1’, while the total amount of catechins in purple-leaf leaves was slightly decreased compared with the control. A R2R3-MYB transcription factor (CsMYB6A) and a novel UGT gene (CsUGT72AM1), that were highly expressed in purple leaf were isolated and identified by transcriptome sequencing. The over-expression of transgenic tobacco confirmed that CsMYB6A can activate the expression of flavonoid-related structural genes, especially CHS and 3GT, controlling the accumulation of anthocyanins in the leaf of transgenic tobacco. Enzymatic assays in vitro confirmed that CsUGT72AM1 has catalytic activity as a flavonol 3-O-glucosyltransferase, and displayed broad substrate specificity. The results were useful for further elucidating the molecular mechanisms of the flavonoid metabolic fluxes in the tea plant.
- Published
- 2018
8. In silico comparison of protein-bound uremic toxin removal by hemodialysis, hemodiafiltration, membrane adsorption, and binding competition
- Author
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Maheshwari, Vaibhav, primary, Thijssen, Stephan, additional, Tao, Xia, additional, Fuertinger, Doris H., additional, Kappel, Franz, additional, and Kotanko, Peter, additional
- Published
- 2019
- Full Text
- View/download PDF
9. Identification of a Flavonoid Glucosyltransferase Involved in 7-OH Site Glycosylation in Tea plants (Camellia sinensis)
- Author
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Yingling Wu, Peiqiang Wang, Guifu Zhao, Liping Gao, Xiaolan Jiang, Xinlong Dai, Tao Xia, Yajun Liu, and Juhua Zhuang
- Subjects
0301 basic medicine ,Glycosylation ,Science ,Flavonoid ,Arabidopsis ,Article ,Camellia sinensis ,03 medical and health sciences ,chemistry.chemical_compound ,Escherichia coli ,Amino Acid Sequence ,Binding site ,Peptide sequence ,Phylogeny ,Flavonoids ,chemistry.chemical_classification ,Binding Sites ,Multidisciplinary ,biology ,Glycosyltransferases ,Glycoside ,biology.organism_classification ,Recombinant Proteins ,Molecular Docking Simulation ,030104 developmental biology ,chemistry ,Biochemistry ,Docking (molecular) ,Mutation ,Mutagenesis, Site-Directed ,biology.protein ,Medicine ,Mutant Proteins ,Glucosyltransferase - Abstract
Flavonol glycosides, which are often converted from aglycones in a process catalyzed by UDP-glycosyltransferases (UGTs), play an important role for the health of plants and animals. In the present study, a gene encoding a flavonoid 7-O-glycosyltransferase (CsUGT75L12) was identified in tea plants. Recombinant CsUGT75L12 protein displayed glycosyltransferase activity on the 7-OH position of multiple phenolic compounds. In relative comparison to wild-type seeds, the levels of flavonol-glucosides increased in Arabidopsis seeds overexpressing CsUGT75L12. In order to determine the key amino acid residues responsible for the catalytic activity of the protein, a series of site-directed mutagenesis and enzymatic assays were performed based on the 3D structural modeling and docking analyses. These results suggested that residue Q54 is a double binding site that functions as both a sugar receptor and donor. Residues H56 and T151, corresponding to the basic active residues H20 and D119 of VvGT1, were not irreplaceable for CsUGT75L12. In addition, residues Y182, S223, P238, T239, and F240 were demonstrated to be responsible for a ‘reversed’ sugar receptor binding model. The results of single and triple substitutions confirmed that the function of residues P238, T239, and F240 may substitute or compensate with each other for the flavonoid 7-O-glycosyltransferase activity.
- Published
- 2017
10. Metabolic Flux Redirection and Transcriptomic Reprogramming in the Albino Tea Cultivar ‘Yu-Jin-Xiang’ with an Emphasis on Catechin Production
- Author
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Zhaoliang Zhang, Liping Gao, Zhuo-Xiao Han, Shu Wei, Xiaochun Wan, Guo-Feng Liu, Lin Feng, Ming-Jun Gao, Tao Xia, and Margaret Y. Gruber
- Subjects
0106 biological sciences ,0301 basic medicine ,Chloroplasts ,Flavonoid ,01 natural sciences ,Camellia sinensis ,Catechin ,Article ,Anthocyanidin reductase ,03 medical and health sciences ,chemistry.chemical_compound ,Flavonols ,Glutamates ,Gene Expression Regulation, Plant ,Botany ,Flavonol synthase ,Flavonoids ,chemistry.chemical_classification ,Multidisciplinary ,biology ,Pigmentation ,fungi ,Computational Biology ,Reproducibility of Results ,food and beverages ,Leucoanthocyanidin reductase ,Molecular Sequence Annotation ,Cellular Reprogramming ,Chloroplast organization ,Plant Leaves ,Phenotype ,030104 developmental biology ,chemistry ,Biochemistry ,biology.protein ,Energy Metabolism ,Transcriptome ,Quercetin ,Metabolic Networks and Pathways ,010606 plant biology & botany - Abstract
In this study, shade-induced conversion from a young pale/yellow leaf phenotype to a green leaf phenotype was studied using metabolic and transcriptomic profiling and the albino cultivar ‘Yu-Jin-Xiang’ (‘YJX’) of Camellia sinensis for a better understanding of mechanisms underlying the phenotype shift and the altered catechin and theanine production. Shaded leaf greening resulted from an increase in leaf chlorophyll and carotenoid abundance and chloroplast development. A total of 1,196 differentially expressed genes (DEGs) were identified between the ‘YJX’ pale and shaded green leaves, and these DEGs affected ‘chloroplast organization’ and ‘response to high light’ besides many other biological processes and pathways. Metabolic flux redirection and transcriptomic reprogramming were found in flavonoid and carotenoid pathways of the ‘YJX’ pale leaves and shaded green leaves to different extents compared to the green cultivar ‘Shu-Cha-Zao’. Enhanced production of the antioxidant quercetin rather than catechin biosynthesis was correlated positively with the enhanced transcription of FLAVONOL SYNTHASE and FLAVANONE/FLAVONOL HYDROXYLASES leading to quercetin accumulation and negatively correlated to suppressed LEUCOANTHOCYANIDIN REDUCTASE, ANTHOCYANIDIN REDUCTASE and SYNTHASE leading to catechin biosynthesis. The altered levels of quercetin and catechins in ‘YJX’ will impact on its tea flavor and health benefits.
- Published
- 2017
11. Enhancing succinic acid biosynthesis in Escherichia coli by engineering its global transcription factor, catabolite repressor/activator (Cra)
- Author
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Li-Na Wei, Li-Wen Zhu, Hong-Mei Li, Zhanpeng Yuan, Shi-Tao Xia, and Ya-Jie Tang
- Subjects
0301 basic medicine ,genetic structures ,Transcription, Genetic ,030106 microbiology ,Mutant ,Glyoxylate cycle ,Catabolite repression ,Succinic Acid ,Repressor ,medicine.disease_cause ,Article ,03 medical and health sciences ,medicine ,Escherichia coli ,Fructosediphosphates ,Transcription factor ,Multidisciplinary ,Chemistry ,Activator (genetics) ,Escherichia coli Proteins ,Glyoxylates ,Gene Expression Regulation, Bacterial ,Repressor Proteins ,030104 developmental biology ,Biochemistry ,Mutation ,Phosphoenolpyruvate carboxykinase ,Transcription Factors - Abstract
This study was initiated to improve E. coli succinate production by engineering the E. coli global transcription factor, Cra (catabolite repressor/activator). Random mutagenesis libraries were generated through error-prone PCR of cra. After re-screening and mutation site integration, the best mutant strain was Tang1541, which provided a final succinate concentration of 79.8 ± 3.1 g/L: i.e., 22.8% greater than that obtained using an empty vector control. The genes and enzymes involved in phosphoenolpyruvate (PEP) carboxylation and the glyoxylate pathway were activated, either directly or indirectly, through the mutation of Cra. The parameters for interaction of Cra and DNA indicated that the Cra mutant was bound to aceBAK, thereby activating the genes involved in glyoxylate pathway and further improving succinate production even in the presence of its effector fructose-1,6-bisphosphate (FBP). It suggested that some of the negative effect of FBP on Cra might have been counteracted through the enhanced binding affinity of the Cra mutant for FBP or the change of Cra structure. This work provides useful information about understanding the transcriptional regulation of succinate biosynthesis.
- Published
- 2016
12. Discovery, screening and evaluation of a plasma biomarker panel for subjects with psychological suboptimal health state using 1H-NMR-based metabolomics profiles
- Author
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Guanhua Du, Huan Xiang, Xue-Mei Qin, Xiang Zhang, Yan-fei Wu, Jun-Sheng Tian, Xiao-tao Xia, and Lei Zhao
- Subjects
Adult ,Male ,0301 basic medicine ,Biomarker panel ,Bioinformatics ,Article ,03 medical and health sciences ,0302 clinical medicine ,Metabolomics ,Humans ,Medicine ,Medicine, Chinese Traditional ,Nuclear Magnetic Resonance, Biomolecular ,Multidisciplinary ,Receiver operating characteristic ,business.industry ,Mental Disorders ,Area under the curve ,Middle Aged ,Clinical trial ,030104 developmental biology ,Clinical diagnosis ,Potential biomarkers ,Correlation analysis ,Female ,business ,Biomarkers ,030217 neurology & neurosurgery ,Drugs, Chinese Herbal - Abstract
Individuals in the state of psychological suboptimal health keep increasing, only scales and questionnaires were used to diagnose in clinic under current conditions, and symptoms of high reliability and accuracy are destitute. Therefore, the noninvasive and precise laboratory diagnostic methods are needed. This study aimed to develop an objective method through screen potential biomarkers or a biomarker panel to facilitate the diagnosis in clinic using plasma metabolomics. Profiles were based on H-nuclear magnetic resonance (1H-NMR) metabolomics techniques combing with multivariate statistical analysis. Furthermore, methods of correlation analysis with Metaboanalyst 3.0 for selecting a biomarker panel, traditional Chinese medicine (TCM) drug intervention for validating the close relations between the biomarker panel and the state and the receiver operating characteristic curves (ROC curves) analysis for evaluation of clinical diagnosis ability were carried out. 9 endogenous metabolites containing trimethylamine oxide (TMAO), glutamine, N-acetyl-glycoproteins, citrate, tyrosine, phenylalanine, isoleucine, valine and glucose were identified and considered as potential biomarkers. Then a biomarker panel consisting of phenylalanine, glutamine, tyrosine, citrate, N-acetyl-glycoproteins and TMAO was selected, which exhibited the highest area under the curve (AUC = 0.971). This study provided critical insight into the pathological mechanism of psychological suboptimal health and would supply a novel and valuable diagnostic method.
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- 2016
- Full Text
- View/download PDF
13. Proteomic profiling of cellulase-aid-extracted membrane proteins for functional identification of cellulose synthase complexes and their potential associated- components in cotton fibers
- Author
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Yanting Wang, Ruyi Wang, Bingrui Wang, Xianliang Li, Liangcai Peng, Tao Xia, Ao Li, Jian Fan, Mingyong Liu, Tingting Chen, Bing Luo, Shengqiu Feng, and Kai Guo
- Subjects
Proteomics ,0106 biological sciences ,0301 basic medicine ,beta-Glucans ,Cellulase ,01 natural sciences ,Article ,03 medical and health sciences ,chemistry.chemical_compound ,Biosynthesis ,Tandem Mass Spectrometry ,Protein purification ,Cotton Fiber ,Cellulose ,Glucans ,Plant Proteins ,chemistry.chemical_classification ,Gossypium ,Multidisciplinary ,biology ,Callose ,Membrane Proteins ,030104 developmental biology ,Enzyme ,Biochemistry ,chemistry ,Membrane protein ,biology.protein ,Chromatography, Liquid ,010606 plant biology & botany - Abstract
Cotton fibers are an excellent model for understanding of cellulose biosynthesis in higher plants. In this study, we determined a high cellulose biosynthesis activity in vitro by optimizing biochemical reaction conditions in cotton fibers. By adding a commercial cellulase enzyme into fibers extraction process, we extracted markedly higher levels of GhCESA1 and GhCESA8 proteins and observed an increase in β-1,4-glucan and β-1,3-glucan products in vitro. LC-MS/MS analysis of anti-GhCESA8-immunoprecipitated proteins showed that 19 proteins could be found in three independent experiments including four CESAs (GhCESA1,2,7,8), five well-known non-CESA proteins, one callose synthase (CALS) and nine novel proteins. Notably, upon the cellulase treatment, four CESAs, one CALS and four novel proteins were measured at relatively higher levels by calculating total peptide counts and distinct peptide numbers, indicating that the cellulase-aid-extracted proteins most likely contribute to the increase in β-glucan products in vitro. These results suggest that the cellulase treatment may aid to release active cellulose synthases complexes from growing glucan chains and make them more amenable to extraction. To our knowledge, it is the first time report about the functional identification of the potential proteins that were associated with plant cellulose and callose synthases complexes by using the cellulase-aided protein extraction.
- Published
- 2016
14. Regulating ehrlich and demethiolation pathways for alcohols production by the expression of ubiquitin-protein ligase gene HUWE1
- Author
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Hong-Mei Li, Rui-Sang Liu, Quan Zhang, Kai-Zhi Jia, Ya-Jie Tang, Yang-Hua Xu, and Shi-Tao Xia
- Subjects
0301 basic medicine ,Propanols ,Ubiquitin-Protein Ligases ,030106 microbiology ,Saccharomyces cerevisiae ,Gene Expression ,Sulfides ,Article ,Metabolic engineering ,Ligase Gene ,03 medical and health sciences ,chemistry.chemical_compound ,Methionine ,Biosynthesis ,Gene Expression Regulation, Fungal ,Amino Acids ,Gene Library ,Regulation of gene expression ,Multidisciplinary ,biology ,Computational Biology ,biology.organism_classification ,Ubiquitin ligase ,030104 developmental biology ,Metabolic Engineering ,chemistry ,Biochemistry ,Suppression subtractive hybridization ,Alcohols ,biology.protein ,Metabolic Networks and Pathways - Abstract
Ehrlich and demethiolation pathways as two competing branches converted amino acid into alcohols. Controlling both pathways offers considerable potential for industrial applications including alcohols overproduction, flavor-quality control and developing new flavors. While how to regulate ehrlich and demethiolation pathways is still not applicable. Taking the conversion of methionine into methionol and methanethiol for example, we constructed two suppression subtractive cDNA libraries of Clonostachys rosea by using suppression subtractive hybridization (SSH) technology for screening regulators controlling the conversion. E3 ubiquitin-protein ligase gene HUWE1 screened from forward SSH library was validated to be related with the biosynthesis of end products. Overexpressing HUWE1 in C. rosea and S. cerevisiae significantly increased the biosynthesis of methanethiol and its derivatives in demethiolation pathway, while suppressed the biosynthesis of methional and methionol in ehrlich pathway. These results attained the directional regulation of both pathways by overexpressing HUWE1. Thus, HUWE1 has potential to be a key target for controlling and enhancing alcohols production by metabolic engineering.
- Published
- 2016
15. A novel mathematical model of protein-bound uremic toxin kinetics during hemodialysis
- Author
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Maheshwari, Vaibhav, primary, Thijssen, Stephan, additional, Tao, Xia, additional, Fuertinger, Doris, additional, Kappel, Franz, additional, and Kotanko, Peter, additional
- Published
- 2017
- Full Text
- View/download PDF
16. Analysis of accumulation patterns and preliminary study on the condensation mechanism of proanthocyanidins in the tea plant [Camellia sinensis]
- Author
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Yajun Liu, Xiaolan Jiang, Fei Meng, Yun sheng Wang, Yumei Qian, Mingzhuo Li, Huarong Tan, Li Liu, Tao Xia, Lei Zhao, Yahui Wu, and Liping Gao
- Subjects
Spectrometry, Mass, Electrospray Ionization ,Magnetic Resonance Spectroscopy ,Degree of polymerization ,Plant Roots ,Article ,Camellia sinensis ,Catechin ,Polymerization ,chemistry.chemical_compound ,Hydrolysis ,Biflavonoids ,Organic chemistry ,Proanthocyanidins ,Procyanidin B2 ,Chromatography, High Pressure Liquid ,Multidisciplinary ,Molecular Structure ,Biosynthetic Pathways ,Plant Leaves ,Monomer ,chemistry ,Biochemistry ,Thiolysis ,Proanthocyanidin ,Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ,Dimerization - Abstract
In the present study, proanthocyanidins were qualitatively and quantitatively identified using hydrolysis and thiolysis assays, NP-HPLC, HPLC-ESI-MS, MALDI-TOF-MS, 1H-NMR and 13C-NMR techniques in different organs of tea plants. The results showed that in leaves, the tri-hydroxyl, cis- and galloylated flavan-3-ols were the main monomeric catechins units and (epi)catechin was found to be the major unit of polymeric flavan-3-ols when the degree of polymerization was greater than five. In roots, the PAs were found to be abundant and epicatechin formed the predominant extension unit of oligomeric and polymeric PAs. In order to understand the mechanism of proanthocyanidins polymerization, auto-condensation of the flavan-3-ols was investigated. The results showed that the same trimers (m/z 865) were detected in the extracts of tea plants and in the non-enzymatic in vitro assay, in weak acid as well as weak alkaline solutions at room temperature, when the substrates used were either procyanidin B2 and monomeric flavan-3-ols (epicatechin or catechin), or only procyanidin B2. This suggested that procyanidin B2 not only released carbocation as electrophilic upper units, but also could be used as nucleophilic lower units directly itself, to form the procyanidin trimer in vitro or in vivo.
- Published
- 2015
17. Improved dialytic removal of protein-bound uraemic toxins with use of albumin binding competitors: an in vitro human whole blood study
- Author
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Tao, Xia, primary, Thijssen, Stephan, additional, Kotanko, Peter, additional, Ho, Chih-Hu, additional, Henrie, Michael, additional, Stroup, Eric, additional, and Handelman, Garry, additional
- Published
- 2016
- Full Text
- View/download PDF
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