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Your search keyword '"Xu, Jianping"' showing total 20 results
Start Over Author "Xu, Jianping" Journal scientific reports
20 results on '"Xu, Jianping"'

10. Selection of Reference Genes for qPCR Analyses of Gene Expression in Ramie Leaves and Roots across Eleven Abiotic/Biotic Treatments

Author

Yu, Yongting, primary, Zhang, Gang, additional, Chen, Yikun, additional, Bai, Qingqing, additional, Gao, Chunsheng, additional, Zeng, Liangbin, additional, Li, Zhimin, additional, Cheng, Yi, additional, Chen, Jia, additional, Sun, Xiangping, additional, Guo, Litao, additional, Xu, Jianping, additional, and Yan, Zhun, additional

Published
2019
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15. Frequent heteroplasmy and recombination in the mitochondrial genomes of the basidiomycete mushroom Thelephora ganbajun

Author

Wang, Pengfei, primary, Sha, Tao, additional, Zhang, Yunrun, additional, Cao, Yang, additional, Mi, Fei, additional, Liu, Cunli, additional, Yang, Dan, additional, Tang, Xiaozhao, additional, He, Xiaoxia, additional, Dong, Jianyong, additional, Wu, Jinyan, additional, Yoell, Shanze, additional, Yoell, Liam, additional, Zhang, Ke-Qin, additional, Zhang, Ying, additional, and Xu, Jianping, additional

Published
2017
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20. (-)-Epigallocatechin-3-gallate (EGCG) attenuates salt-induced hypertension and renal injury in Dahl salt-sensitive rats.

Author

Luo D, Xu J, Chen X, Zhu X, Liu S, Li J, Xu X, Ma X, Zhao J, and Ji X

Subjects
Administration, Oral, Animals, Apoptosis drug effects, Catechin administration & dosage, Catechin metabolism, Catechin pharmacology, Cells, Cultured, Disease Models, Animal, Fibroblasts pathology, Malondialdehyde metabolism, Rats, Rats, Inbred Dahl, Receptors, Laminin metabolism, Acute Kidney Injury drug therapy, Acute Kidney Injury etiology, Catechin analogs & derivatives, Hypertension drug therapy, Hypertension etiology, Phytotherapy, Sodium Chloride, Dietary adverse effects
Abstract

Epigallocatechin-3-gallate (EGCG), a main active catechin in green tea, was reported to attenuate renal injury and hypertension. However, its effects on salt-induced hypertension and renal injury remain unclear. In the present study, we explored its effects on hypertension and renal damage in Dahl rats with salt-sensitive hypertension. We found that EGCG could lower blood pressure after 6 weeks of oral administration, reduce 24 h urine protein levels and decrease creatinine clearance, and attenuate renal fibrosis, indicating that it could attenuate hypertension by protecting against renal damage. Furthermore, we studied the renal protective mechanisms of EGCG, revealing that it could lower malondialdehyde levels, reduce the numbers of infiltrated macrophages and T cells, and induce the apoptosis of NRK-49F cells. Considering that the 67 kD laminin receptor (67LR) binds to EGCG, its role in EGCG-induced fibroblast apoptosis was also investigated. The results showed that an anti-67LR antibody partially abrogated the apoptosis-inducing effects of EGCG on NRK-49F cells. In summary, EGCG may attenuate renal damage and salt-sensitive hypertension via exerting anti-oxidant, anti-inflammatory, and apoptosis-inducing effects on fibroblasts; the last effect is partially mediated by 67LR, suggesting that EGCG represents a potential strategy for treating salt-sensitive hypertension.

Published
2020
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