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This article provides an overview of recent advancements in transition-metal-catalyzed Sonogashira cross-coupling reactions of alkyl electrophiles. It discusses the challenges associated with coupling nonactivated alkyl electrophiles and highlights three catalytic systems that have been developed to address these challenges. The article also mentions the development of enantioselective Sonogashira reactions using copper catalysts with chiral ligands. The challenges and future directions in this field are also discussed. [Extracted from the article]

This document provides information on the synthesis of a COVID-19 therapeutic drug called Ensitrelvir. The addition of LiCl (lithium chloride) was found to facilitate the generation of lithium triazinolate, which improved the yield and selectivity of the N-alkylation process. The use of LiCl and Et3N (triethylamine) also simplified the work-up operation and allowed for the use of a cheaper and more readily available base. The method was effective for various electrophiles, and further investigation is being conducted on the substrate scope of nucleophiles. The document also includes information on the physical and spectroscopic properties of the synthesized compounds, as well as acknowledgments and additional supporting information. [Extracted from the article]

This article discusses the synthesis and characterization of several compounds, including piperazinone derivatives. The compounds are described in terms of their chemical structures, physical properties, and spectroscopic data. The authors provide detailed information about the synthesis procedure, yield, and characterization techniques used. This information can be useful for researchers studying these specific compounds or related topics. The authors acknowledge the University of Belgrade, Faculty of Pharmacy for their support, and additional supporting information is available online. [Extracted from the article]

[34] The reaction with enantioenriched -methylbenzylboronic acid pinacol ester resulted in a 56:44 diastereomeric mixture of alcohol products B 48 b , the same diastereomeric mixture as was observed using racemic alkylboronic ester. [3][5][6] This short review details our laboratory's examination of reactions using benzylboronic acid pinacol ester and secondary and tertiary benzylboronic esters as nucleophiles. Keywords: boron; benzylation; Lewis base; copper; boronate EN boron benzylation Lewis base copper boronate 2639 2647 9 08/17/23 20230901 NES 230901 Graph 1 Introduction Organoboranes have found great utility in organic synthesis. Specifically, substrates containing esters and amides to the ketone were found to be compatible under these reaction conditions with no reaction being observed at the ester or amide carbonyl carbon ( B 25 b and B 26 b ). [Extracted from the article]

IR (C SB 2 sb H SB 2 sb Cl SB 2 sb ): 1675, 1620 cm SP -1 sp . This had also been observed for deoxyhalogenation reactions using Ph SB 3 sb PX SB 2 sb reagents in the presence of triethylamine. This transformation is already well-documented: COCl SB 2 sb , PCl SB 3 sb , OPCl SB 3 sb , acetyl and oxalyl chlorides, triphenylphosphine-derived reagents Ph SB 3 sb PX SB 2 sb , Ph SB 3 sb P/CX SB 4 sb and the Vilsmeier reagent have been successfully used. 3-Chloro-6-allylcyclohex-2-en-1-one (21a) 1518 The title product was prepared using 0.183 g (1.4 mmol) of TMCE ( B 2a b ) and 0.189 g (1.2 mmol) of 4-allylcyclohexan-1,3-dione in CH SB 2 sb Cl SB 2 sb for 5 h at rt. [Extracted from the article]

The reduction of alkyl chlorides using triethylsilane is investigated. Primary, secondary, tertiary, and benzylic C–Cl bonds are effectively converted into C–H bonds using an [IrCl(cod)]2 /2,6-bis(benzimidazol-2′-yl)pyridine catalyst system. This catalyst system is quite simple since the tridentate N-ligand can be easily prepared in one step from commercially available reagents. [ABSTRACT FROM AUTHOR]

Alkyl aryl ketones were prepared on a gram scale by the nickel-catalyzed reductive coupling of alkyl iodides with aroyl chlorides. When scaled up 30-fold, this reaction shows a comparable coupling efficiency to the previously reported reaction performed under smallscale conditions. The mild and convenient reaction conditions show excellent tolerance to a range of functional groups and provide the ketones in good to excellent yields [ABSTRACT FROM AUTHOR]

Secondary alkyl chlorides have been efficiently prepared from secondary alkyl sulfonates under mild and user-friendly conditions. The exchange reaction was generally performed by using benzyltributylammonium chloride in acetone (reflux, 30 min). Yields are excellent from functionalized, base-sensitive and hindered secondary alkyl sulfonates [ABSTRACT FROM AUTHOR]