1. One-pot synthesis of polysubstituted pyridine derivatives using ketene dithioacetals
- Author
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Hagimori, Masayori, Mizuyama, Naoko, Hisadome, Yukari, Nagaoka, Junko, Ueda, Kazuo, and Tominaga, Yoshinori
- Subjects
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BIOSYNTHESIS , *PYRIDINE derivatives , *KETENES , *HETEROCYCLIC compounds - Abstract
Abstract: Polysubstituted pyridine derivatives were synthesized by the reaction of ketene dithioacetal, 3,3-bis(methylsulfanyl)methylenemalononitrile 1b, with a variety of active methylene compounds in the presence of either sodium hydroxide or potassium hydroxide as a base in DMSO. This reaction was carried out under economical one-pot reaction conditions (cheap catalyst and solvent) and solved the problem of the odor of methanethiol, commonly derived from reactions of ketene dithioacetals. This is a significant enhancement of GSC (green and sustainable chemistry) in the field of ketene dithioacetal chemistry. [Copyright &y& Elsevier]
- Published
- 2007
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