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Three new isocoumarins and two new phthalides, tubakialactones A–E ( 1 – 5 ), together with three known polyketides including ( R )-3,4-dihydro-4-hydroxyl-6,8-dimethoxy-4-methyl-3-methylene-1 H -2-benzopyran-1-one ( 6 ), (−)-5,7-dimethoxy-3-methyl-1(3 H )-isobenzofuranone ( 7 ), and isosclerone ( 8 ) were found in the endophytic fungus Tubakia sp. ECN-111 isolated from the leaves of Houttuynia cordata . The chemical structures of the new compounds were determined by spectroscopic analyses, including extensive 2D-NMR experiments. The absolute configuration of 3 and 7 was determined by optical rotation and circular dichroism. [ABSTRACT FROM AUTHOR]

Diaporthols A ( 1 ) and B ( 2 ), two diphenyl ether derivatives, were isolated from cultures of an endophytic fungus Diaporthe sp. ECN-137 obtained from the leaves of Phellodendron amurense . The structures of 1 and 2 were determined by extensive spectroscopic analyses, and the structure of 2 was confirmed by X-ray crystallographic analysis. Compounds 1 and 2 showed anti-migration activities in TGF-β1-elicited MDA-MB-231 breast cancer cells at a concentration of 20 μM. [ABSTRACT FROM AUTHOR]