1. Tubakialactones A–E, new polyketides from the endophytic fungus Tubakia sp. ECN-111.
- Author
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Nakashima, Ken-ichi, Tomida, Junko, Hirai, Takao, Morita, Yuji, Kawamura, Yoshiaki, and Inoue, Makoto
- Subjects
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LACTONES , *POLYKETIDES , *ENDOPHYTIC fungi , *PHTHALIDES , *COUMARINS , *NUCLEAR magnetic resonance spectroscopy - Abstract
Three new isocoumarins and two new phthalides, tubakialactones A–E ( 1 – 5 ), together with three known polyketides including ( R )-3,4-dihydro-4-hydroxyl-6,8-dimethoxy-4-methyl-3-methylene-1 H -2-benzopyran-1-one ( 6 ), (−)-5,7-dimethoxy-3-methyl-1(3 H )-isobenzofuranone ( 7 ), and isosclerone ( 8 ) were found in the endophytic fungus Tubakia sp. ECN-111 isolated from the leaves of Houttuynia cordata . The chemical structures of the new compounds were determined by spectroscopic analyses, including extensive 2D-NMR experiments. The absolute configuration of 3 and 7 was determined by optical rotation and circular dichroism. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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