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The readily available C2-symmetric bis(aziridines) 1 can act as ligands in a variety of asymmetric transformations mediated by transition metals. In the best cases, >95% ee can be obtained.

The C2-symmetric aziridines 1 and 1′ (available from (+)- and (−)-tartaric acid, respectively) are excellent chiral auxiliaries for asymmetric alkylation and aldol reactions.

A novel and diastereoselective entry to the β-lactam nucleus of the carbapenems starting from L-glutamic acid is exemplified by the synthesis of the potential (+)-PS-5 intermediate 13 .

The non-racemic C2-symmetric azirdines7 and8, easily available from (+)- and (-)-tartaric acid, respectively, undergo rapid nucleophilic attack to yield products formally derived from the β-cation ofL- orD-aspartic acid.

An efficient enantioselective total synthesis of the antibiotic (+)-negamycin is described, the absolute stereochemistry deriving from ( R )-(+)-malic acid and subsequent use of the Sharpless asymmetric epoxidation reaction.

The title compound has been synthesised by a reductive coupling of bibenzyl-4,4′- dicarbaldehyde and its dynamic properties and photoinduced isomerisations are briefly described.

The molecular structure and dynamic behaviour of the bridged [4n] annulene 1,6:9,14-bismethano-[16]annulene is unravelled by NMR and X-ray investigations, combined with force field calculations.

Reductive coupling of cychoheptatriene-1,6-dialdehyde using a low-valent titanium reagent provides a one-step route to a paratropic bismethano [16] annulene.

Two simple, efficient and stereocontrolled routes to the cis -azaspiro-[5-5]-undecan-8-ol skeleton of the histrionicotoxin alkaloids are described.

The structure and dynamic stereochemistry of a novel paracyclophane formed by electrocyclic ring closure of a hexatriene-bridged precursor are described.

A short and completely stereocontrolled total synthesis of the title alkaloid is described, the key step being spirocyclisation of the epoxy sulfone 4 .