1. Comparative transcriptome profiling provides new insights into mechanisms of androgenetic alopecia progression
- Author
-
Elaine G.Y. Chew, B.S.‐Y. Ho, Srinivas Ramasamy, Paul L. Bigliardi, W.M.S. Leong, Mei Bigliardi-Qi, Axel M. Hillmer, Xingliang Liu, S.Y.S. Yang, C. Tennakoon, H. Jaffar, S.Y.D. Lim, and Thomas L. Dawson
- Subjects
0301 basic medicine ,Adult ,Male ,medicine.medical_specialty ,medicine.drug_class ,education ,Dermatology ,Terminal hair ,Biology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Follicle ,Young Adult ,0302 clinical medicine ,Internal medicine ,medicine ,Genetic predisposition ,Transcriptome profiling ,Humans ,reproductive and urinary physiology ,Aged ,integumentary system ,Gene Expression Profiling ,Oxidation reduction ,Alopecia ,Middle Aged ,Androgen ,medicine.disease ,female genital diseases and pregnancy complications ,Up-Regulation ,body regions ,030104 developmental biology ,Endocrinology ,Hair loss ,Case-Control Studies ,Vellus hair ,Cancer research ,Disease Progression ,Hair Follicle ,Oxidation-Reduction - Abstract
Androgenetic alopecia (AGA) is the most common progressive form of hair loss that occurs in more than half of men above 50 years 1. AGA onset is dependent on genetic predisposition and presence of androgen 2, 3. In AGA patients, hair undergoes shortened anagen phase, progressive miniaturization and subsequent vellus transformation of terminal hair follicle. This article is protected by copyright. All rights reserved.
- Published
- 2016