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Your search keyword '"Mayuko Muro"' showing total 2 results
Start Over Author "Mayuko Muro" Journal the journal of dermatological treatment
2 results on '"Mayuko Muro"'

1. Topical combination therapy with vitamin D3 and corticosteroid ointment for palmoplantar pustulosis: A prospective, randomized, left-right comparison study

Author

Hiroshi Kawakami, Yuka Matsumoto, Namiko Abe, Mayuko Muro, Ryoji Tsuboi, and Yukari Okubo

Subjects
Vitamin, Adult, Male, medicine.medical_specialty, Palmoplantar pustulosis, Erythema, Combination therapy, medicine.drug_class, Administration, Topical, Hyperkeratosis, Dermatology, Ointments, 030207 dermatology & venereal diseases, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Calcitriol, Psoriasis, medicine, Humans, Prospective Studies, Glucocorticoids, Aged, 030203 arthritis & rheumatology, Skin Diseases, Vesiculobullous, business.industry, Middle Aged, medicine.disease, Regimen, Treatment Outcome, chemistry, Corticosteroid, Drug Therapy, Combination, Female, Dermatologic Agents, medicine.symptom, business
Abstract

Vitamin D3 ointment and corticosteroid ointment are both used for the treatment of palmoplantar pustulosis (PPP). However, to date there is no systematic study of the efficacy of combination therapy for the treatment of PPP.We compared the efficacy of a topical combination therapy with vitamin D3 and a topical corticosteroid with that of topical corticosteroid alone in the treatment of PPP.We evaluated left-right comparison study of the efficacy of a combination therapy consisting of maxacalcitol ointment and betamethasone butyrate propionate ointment (BBP), and monotherapy with BBP alone in 27 patients with PPP for 8 weeks.The improvement in the symptom (erythema, pustules/vesicles, hyperkeratosis/scales) scores was high for the combination therapy. In particular, the improvement rate for pustules/vesicles at week 8 after the combination therapy was significantly higher than for the monotherapy (p 0.05).This combination regimen demonstrated that not only topical corticosteroids, but also topical vitamin D3 ointment, is useful for the treatment of PPP.

Published
2015

2. Combination therapy using maxacalcitol and corticosteroid lotions preliminary to monotherapy with maxacalcitol lotion for scalp psoriasis

Author

Shoko Natsume, Mayuko Muro, Kae Usui, Ryoji Tsuboi, and Yukari Okubo

Subjects
Adult, Male, medicine.medical_specialty, Combination therapy, medicine.drug_class, Administration, Topical, Anti-Inflammatory Agents, Skin Cream, Topical treatment, Dermatology, Administration, Cutaneous, Betamethasone, Drug Administration Schedule, Calcitriol, medicine, Humans, Psoriasis, Aged, business.industry, Drug Substitution, Middle Aged, Skin symptoms, Drug Combinations, medicine.anatomical_structure, Scalp Dermatoses, Lotion, Scalp, Betamethasone Butyrate Propionate, Corticosteroid, Drug Therapy, Combination, Female, Dermatologic Agents, business, Scalp psoriasis
Abstract

Topical treatment with betamethasone butyrate propionate lotion on 37 patients with scalp psoriasis was replaced with a combination therapy using maxacalcitol lotion (on weekdays) and BBP (on the weekends). This combination therapy was later switched to MXA monotherapy. To identify the optimum duration of the combination therapy, the patients were divided into two groups: a 4-week group and an 8-week group, which were given combination therapy and monotherapy. In both groups, the total mean scores for the skin symptoms had significantly improved in comparison with that obtained at the outset of the study (p0.01). In terms of overall improvement, 20.0% of the 4-week group and 72.7% of the 8-week group yielded scores reflecting moderate or greater improvement. The treatment administered to the 8-week group was significantly more effective than that given to the 4-week group at the end of the trial (p0.01). This study also suggests that a 4-week combination therapy is an option before switching to monotherapy, but that an 8-week therapy is preferable in severe cases.

Published
2012

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