1. Multiple Roles for Slits in the Control of Cell Migration in the Rostral Migratory Stream
- Author
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Anne Baron-Van Evercooren, Kim T. Nguyen-Ba-Charvet, Alain Chédotal, Nathalie Picard-Riera, Marc Tessier-Lavigne, Constantino Sotelo, Neurobiologie des processus adaptatifs (NPA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Affections de la Myeline et des Canaux Ioniques Musculaires, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Biology [Stanford], Stanford University, and INSERM, CEE QLK3-CT-1999-00894, French Ministry for Research (ACI number 5116), 'Association Pour la Recherche sur le Cancer', Fondation de France, Fondation de la Recherche Médicale (FRM).
- Subjects
Rostral migratory stream ,animal diseases ,Development/Plasticity/Repair ,Subventricular zone ,Mice, Transgenic ,Nerve Tissue Proteins ,Biology ,Mice ,03 medical and health sciences ,0302 clinical medicine ,Cell Movement ,Genes, Reporter ,Interneurons ,Lateral Ventricles ,Neurosphere ,SLIT1 ,medicine ,SLIT2 ,Animals ,Receptors, Immunologic ,Cells, Cultured ,030304 developmental biology ,Mice, Knockout ,0303 health sciences ,Chemotaxis ,Stem Cells ,General Neuroscience ,Cell Differentiation ,Cell migration ,Olfactory Bulb ,Slit ,Olfactory bulb ,Cell biology ,medicine.anatomical_structure ,nervous system ,Choroid Plexus ,Intercellular Signaling Peptides and Proteins ,Septum of Brain ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Neuroscience ,Cell Division ,030217 neurology & neurosurgery - Abstract
The subventricular zone (SVZ) contains undifferentiated cells, which proliferate and generate olfactory bulb (OB) interneurons. Throughout life, these cells leave the SVZ and migrate along the rostral migratory stream (RMS) to the OB where they differentiate.In vitro, the septum and the choroid plexus (CP) secrete repulsive factors that could orient the migration of OB precursors. Slit1 and Slit2, two known chemorepellents for developing axons, can mimic this effect. We show here that the Slit receptors Robo2 and Robo3/Rig-1 are expressed in the SVZ and the RMS and that Slit1 and Slit2 are still present in the adult septum. UsingSlit1/2-deficient mice, we found that Slit1 and Slit2 are responsible for both the septum and the CP repulsive activityin vitro. In adult mice lacking Slit1, small chains of SVZ-derived cells migrate caudally into the corpus callosum, supporting a role for Slits in orienting the migration of SVZ cells. Surprisingly, in adult mice, Slit1 was also expressed by type A and type C cells in the SVZ and RMS, suggesting that Slit1 could act cell autonomously. This hypothesis was tested using cultures of SVZ explants or isolated neurospheres fromSlit1-/- orSlit1+/- mice. In both types of cultures, the migration of SVZ cells was altered in the absence of Slit1. This suggests that the regulation of the migration of OB precursors by Slit proteins is complex and not limited to repulsion.
- Published
- 2004