1. The prognostic value of anterior commissure involvement in T1 glottic cancer: A systematic review and meta‐analysis
- Author
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Michele Tulli, Massimo Re, Mario Bussi, Andrea Galli, Leone Giordano, Federico Maria Gioacchini, Stefano Bondi, Luigi Ferrante, Marianxhela Dajko, Tulli, Michele, Re, Massimo, Bondi, Stefano, Ferrante, Luigi, Dajko, Marianxhela, Giordano, Leone, Gioacchini, Federico M, Galli, Andrea, and Bussi, Mario
- Subjects
Glottis ,medicine.medical_specialty ,Prognostic factor ,education ,Anterior commissure ,03 medical and health sciences ,0302 clinical medicine ,otorhinolaryngologic diseases ,medicine ,Humans ,030223 otorhinolaryngology ,Laryngeal Neoplasms ,Neoplasm Staging ,business.industry ,Rate control ,respiratory system ,Prognosis ,Confidence interval ,Glottic Squamous Cell Carcinoma ,Observational Studies as Topic ,Otorhinolaryngology ,Glottic cancer ,030220 oncology & carcinogenesis ,Meta-analysis ,Carcinoma, Squamous Cell ,TNM Staging ,Radiology ,business - Abstract
OBJECTIVE The anterior commissure is considered a laryngeal subsite, but it is not taken into account in the current T-staging system. The impact of anterior commissure involvement (ACI) on the oncologic outcomes of T1 glottic tumors has not been well defined and remains controversial. The aim of this study was to assess the influence of ACI in the prognosis of T1 glottic tumors. METHODS A systematic review and meta-analysis of observational studies was performed by including studies published up to July 2019. Studies were selected if they had investigated the local control rate (LCR) at 5 years of clinical stage I (T1 and N0) glottic squamous cell carcinoma with and without ACI. The difference in LCR at 5 years between T1 glottic tumors without and with ACI was evaluated. RESULTS The meta-analysis showed that the difference in LCR at 5 years between T1 glottic tumors without and with ACI is 12% (95% confidence interval: 8%-16%, p
- Published
- 2019