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1. [Ehrlich tumor cells stimulate T-cell production of interferon-gamma and are resistant to autocrine nitric oxide].

Author

Bel'skiĭ IuP, Bel'skaia NV, Danilets MG, Trofimova ES, Patrushev VK, and Agafonov VI

Subjects
Animals, Female, Male, Mice, Mice, Inbred C57BL, Mice, Inbred DBA, Autocrine Communication, Carcinoma, Ehrlich Tumor metabolism, Interferon-gamma biosynthesis, Nitric Oxide metabolism, T-Lymphocytes metabolism
Abstract

Ehrlich tumor cells released factors which activated T-cell production of interferon-gamma and triggered a mechanism of nitric oxide (NO) production instead of interferon-gamma. When cultured in vitro, they produced NO without stimulation and responded to interferon-gamma by an output rate of NO significantly greater than that in bone marrow cells. Unlike P-815 cells, those of Ehrlich tumor proved resistant to autocrine NO.

Published
2004

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