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Taking Xinji No.2 mine in Xinji Mining Area as the research object, with the help of the field advantage of the floor rock roadway in the mining area, the monitoring array effects under different combinations of coal roadway and floor rock roadway were compared and analyzed through field tests. Three spatial three-dimensional “coal-rock” micro-seismic monitoring arrays based on floor rock roadway are proposed, which are “point-surface”, “line-line” and “line-surface” respectively, and the existing micro-seismic monitoring array layout was optimized. The research shows that the “coal-rock” spatial three-dimensional micro-seismic monitoring method has made significant progress in terms of positioning accuracy, monitoring range, service cycle and economic cost.

The low-carbon transformation of power sector is significant for achieving the goal of carbon peak and carbon neutrality in China. Based on the evaluation of power carbon budget, three power transformation scenarios of deep low-carbon, zero carbon, and negative carbon were built, the key boundary conditions such as power consumption demand were studied, and a path planning optimization model was established in the paper. Using the GESP-V software package for optimized analysis, the low-carbon transformation paths were determined for power structure, power carbon emissions, and power supply costs under different scenarios. The major issues that are critical for the low-carbon transformation of the power system were discussed, including coal power development, renewable energy development and utilization, diversified supply of clean energy, and electric power balance. Several suggestions were further proposed. Specifically, the top-level design should be strengthened to steadily plan the transformation pace, major low-carbon technologies should be developed to coordinate the overall technology and industrial layout, and the market mechanism with balanced interests should be improved while establishing a green finance policy system. The high-quality low-carbon transformation of China’s power sector in the medium and long term can be promoted through the coordination of policies, technologies, and mechanisms.

Excessive psychrophilic bacteria in raw milk can produce high levels of heat-stable protease and lipase, both of which are important causes of quality problems when cow's milk enters the shelf life. In order to explore the microbial diversity of cows' living environment in pasture and different stages in the raw milk circulation process, the pollution source of psychrophilic bacteria in the pasture was found out. In this study, we collected five samples in a large-scale dairy farm in Hebei Province $ TMR feed, cowshed pad soil, the first three milks, the normal milk after the first three milks, and the raw milk in the milk tank, and analyzed the bacterial community structure, psychrophilic species, abundance of psychrophilic bacteria in all samples by using metagenomic shotgun sequencing technology. The results showed that the mainly microbial were Proteobacteria, Firmicutes, and Actinobacteria at phylum level. At the genus level, the main genera were Anaplasma, Streptococcus, Enterococci, Spirospirita, Bacillus, and Pseudomonas. The soil of the barn contains 99.63% and 96.39% of the species of Pseudomonas in the normal milk and the total milk of the pasture storage tank, indicating that the soil of the barn mat is a potential source of pollution of various types of Pseudomonas. [ABSTRACT FROM AUTHOR]

In order to solve the problem that alumina based ceramic core is not easy to remove core, a certain amount of PA66 fiber was added as pore forming material to prepare porous aluminum based ceramic core by hot pressing. The influence of PA66 fiber content on the porosity, room temperature bending strength and sintering shrinkage of aluminum based ceramic core was investigated, and the mechanism of PA66 fiber content on the porosity of aluminum based ceramic core was analyzed. The results show that the porosity of alumina based ceramic core is significantly increased by adding PA66 fiber, and the sintering shrinkage of the core is effectively blocked. With the increase of PA66 fiber, the porosity of alumina based ceramic core is increased, and the bending strength and line shrinkage rate at room temperature are decreased. When the PA66 fiber content is 0.9%(mass fraction), the porosity of the aluminum based ceramic core is 41.14%, the bending strength is 15.33 MPa, and the linear shrinkage rate is 0.418%.

The vibration failure issue of the motor control unit during the vibration test was studied,and the reasons of the failure were analyzed by applying spectrum analysis method,the results showed that the coupled vibration is the main reason of the vibration failure. The optimization schemes against this problem were designed,the octave criterion was applied to design the component for avoiding coupled vibration,and the damping was increased to decrease the peak of the vibration response. The optimization schemes were verified by simulation and experiment,the results showed the vibration acceleration decreased by 23% ～ 31% using octave criterion design,and decreased by 25% ～ 34% through increasing damping. The conclusion can be drawn that two optimization ways can decrease vibration acceleration level obviously,and the fatigue durability of the product was improved.

Relying on the advantages of simple and fast applications, easy deployment of applications, and on-demand scaling of running applications, cloud native technology has been rapidly promoted. However, with the application of cloud native, the system architecture has become more complex and the scale of resources has become larger, and there is an urgent need for more intelligent operation and maintenance. Using intelligent operation and maintenance can better assist cloud-native application development, reduce operation and maintenance costs, and improve service quality. The application scenarios, key points, classic practices and existing problems of intelligent operation and maintenance were analyzed, and a cloud-native intelligent operation and maintenance architecture were proposed, and the main principles of the three scenarios: the trend prediction, data anomaly detection and fault location diagnosing in the core service algorithm platform were introduced in detail, and finally the future of intelligent operation and maintenance were looked forward. [ABSTRACT FROM AUTHOR]

With the development of 5G, the 5G private network enables the industry and shows great market opportunities. Lightweight 5G core products based on cloud native are the most important components of the 5GC private network. Lightweight 5G core products, using cloud native technology for design and development deployment, can maximize the realization of Agile development, rapid deployment, customized resources and flexible service innovation of lightweight 5G core. The product definition, requirement, application and industry were analyzed. And key technologies were analyzed, including lightweight framework, lightweight operation, multi-protocol access and high availability disaster recovery technology. [ABSTRACT FROM AUTHOR]

The hybrid power system based on multi-input converter can work under suitable mode with power management strategy which has been put forward and interleaved dual-edge modulation PWM. It also can solve a major problem that the track of maximum power fails when photovoltaic cells and the commercial power supply are load at the same time. Now a new drive method is put forward-inter-lock. This method can not only solve the problem, but also have low fluctuation of the system current. The paper theoretically analyzes the modulation effects of inter-lock drive, and compares it with dual-edge modulation PWM. Then Matlab/Simulink is used to establish inter-locking model and simulate It verifies the effectiveness of inter-lock driving method. [ABSTRACT FROM AUTHOR]

Objective To observe the effect of clinical intermediate care for elderly patients. Methods According to the diagnostic criteria and inclusion criteria, 200 elderly patients were randomly divided into experimental group (re = 100) and control group (n =1000). Elderly patients of tested group were managed with clinical intermediate care in hospital for 4 weeks, while patients of control group were at home. All patients were assessed 2 weeks, 4 weeks, 3 months and 6 months by comprehensive geriatric assessment after discharge. Results After intervention, indicators of comprehensive geriatric assessment in the experimental group were superior to those in the control group (P< 0.05). In the experimental group, indicators of elderly patients were continuously improved with time (P < 0.05). Conclusion Clinical intermediate care is contributive to the improvement of elderly patients' psychological states, body functions and the quality of life. [ABSTRACT FROM AUTHOR]

In the hybrid power system based on double-input buck converter and power management strategy which has been put forward, we can keep the system working under suitable mode. But when the two IGBT switches at the same time, due to the reverse bias voltage, the flywheel diode wiil cut off. The commercial power current must flow through the photovoltaic that wiil affect measurement of Photovoltaic current seriously. Interleaved dual-edge modulation and inter-lock can solve the problem, theoretical analysis wiil be listed to prove the consistency of the two method. The simulation results of interleaved dual-edge modulation based on Matlab/Simulink model have confirmed the effectiveness. [ABSTRACT FROM AUTHOR]

Combined with the problem of missile equipment readiness army recently concerned about, the important parameter of readiness rate affecting missile equipment readiness was researched, and an evaluation method and model of missile equipment readiness rate based on diffusion process was given. According to the related service information of missile equipment, the model was evaluated and verified. This method is accurate to analyze the readiness rate, and has reference value to improve missile readiness rate later. [ABSTRACT FROM AUTHOR]

Chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS) is a common urological disease with complex etiology. The treatment effect of western medicine is not satisfactory, and the course of the disease is protracted, which brings great trouble to patients. Traditional Chinese medicine(TCM) has a variety of treatment methods based on syndrome differentiation and treatment, including internal treatment with TCM, acupuncture and massage, and other external treatment methods for comprehensive treatment, with significant effect. This study summarized the etiology and pathogenesis of CP/CPPS and found that western medicine cannot fully explain the etiology and pathogenesis of CP/CPPS. It was believed that CP/CPPS was mainly related to many factors such as special pathogen infection, voiding dysfunction, mental and psychological abnormalities, neuroendocrine abnormalities, immune abnormalities, excessive oxidative stress, pelvic diseases, and heredity. TCM believed that CP/CPPS was caused by damp heat, blood stasis, Qi stagnation, and poisoning and was closely related to the organs of the liver, spleen, kidney, lung, stomach, bladder, and meridians of Chong and Ren channels and three yin channels of the foot. In the treatment of TCM, multiple comprehensive treatment plans are currently used, including internal treatment with TCM(decoction, proprietary Chinese medicine, and unique therapies of famous doctors), acupuncture and massage treatment, and other external treatment methods(rectal administration, topical application of TCM, and ear acupoint pressure). Comprehensive regulation has significant clinical efficacy and prominent characteristics of TCM, and it is worth clinical promotion. This study aims to provide a reference for clinical prevention and treatment of CP/CPPS and points out potential directions for future research in this field.

Oral squamous cell carcinoma (OSCC) is a prevalent malignant tumor affecting the head and neck region (Leemans et al., 2018). It is often diagnosed at a later stage, leading to a poor prognosis (Muzaffar et al., 2021; Li et al., 2023). Despite advances in OSCC treatment, the overall 5-year survival rate of OSCC patients remains alarmingly low, falling below 50% (Jehn et al., 2019; Johnson et al., 2020). According to statistics, only 50% of patients with oral cancer can be treated with surgery. Once discovered, it is more frequently at an advanced stage. In addition, owing to the aggressively invasive and metastatic characteristics of OSCC, most patients die within one year of diagnosis. Hence, the pursuit of novel therapeutic drugs and treatments to improve the response of oral cancer to medication, along with a deeper understanding of their effects, remains crucial objectives in oral cancer research (Johnson et al., 2020; Bhat et al., 2021; Chen et al., 2023; Ruffin et al., 2023).

Objective: To investigate the c-Jun N-terminal kinase (JNK), CCAAT/enhancer-binding protein homologous protein (CHOP) pathway apoptosis and the changes of cytokine levels in immune-related organs and tissues of sepsis mice at different time points., Methods: Twenty-seven male BALB/c mice were divided into normal group, sepsis 6 hours group and sepsis 12 hours group by the block randomization method, with 9 mice in each group. The sepsis model was made by cecal ligation and puncture (CLP). Blood sample was collected from each group at the corresponding time point, and the serum levels of tumor necrosis factor-α (TNF-α), interleukin (IL-1β, IL-10) were measured by enzyme linked immunosorbent assay (ELISA). The spleen, thymus and appendix tissues were taken from the mice to detect the expressions of phosphorylation-JNK (p-JNK), JNK1, CHOP and cleaved caspase-3 protein by Western Blot., Results: The level of cytokines, p-JNK/JNK1 ratio, CHOP and caspase-3 in spleen tissues, and the CHOP, caspase-3 in thymus and appendix tissue in the sepsis 6 hours group were significantly higher than those in the normal group [serum TNF-α (ng/L): 24.29±3.09 vs. 2.93±2.09, serum IL-1β (ng/L): 5.00±3.19 vs. 3.54±1.53, serum IL-10 (ng/L): 1 963.93±270.20 vs. 275.09±45.21, spleen p-JNK/JNK1 ratio: 0.257±0.126 vs. 0.154±0.068, spleen CHOP/β-actin: 0.201±0.131 vs. 0.142±0.068, spleen caspase-3/β-actin: 0.215±0.126 vs. 0.098±0.088, thymus CHOP/β-actin: 0.122±0.071 vs. 0.089±0.067, thymus caspase-3/β-actin: 0.258±0.145 vs. 0.108±0.045, appendix CHOP/β-actin: 0.361±0.134 vs. 0.215±0.112, appendix caspase-3/β-actin: 0.439±0.211 vs. 0.321±0.145, all P < 0.05]. However, there were no significant difference in the p-JNK/JNK1 ratio in thymus and appendix (thymus p-JNK/JNK1 ratio: 1.221±0.776 vs. 1.168±0.475, appendix p-JNK/JNK1 ratio: 2.014±1.227 vs. 1.828±0.915, both P > 0.05). Cytokine levels and the p-JNK/JNK1 ratio, CHOP, caspase-3 in spleen, thymus, and appendix in the sepsis 12 hours group were further increased when compared with those in the sepsis 6 hours group, except for a significant decrease in IL-10 level [serum IL-10 (ng/L): 1 698.98±210.52 vs. 1 963.93±270.20, serum TNF-α (ng/L): 41.66±6.57 vs. 24.29±3.09, serum IL-1β (ng/L): 10.37±4.14 vs. 5.00±3.19, spleen p-JNK/JNK1 ratio: 0.399±0.135 vs. 0.257±0.126, spleen CHOP/β-actin: 0.298±0.145 vs. 0.201±0.131, spleen caspase-3/β-actin: 0.353±0.145 vs. 0.215±0.126, thymus p-JNK/JNK1 ratio: 1.667±0.891 vs. 1.221±0.776, thymus CHOP/β-actin: 0.207±0.133 vs. 0.122±0.071, thymus caspase-3/β-actin: 0.416±0.179 vs. 0.258±0.145, appendix p-JNK/JNK1 ratio: 2.425±1.361 vs. 2.014±1.227, appendix CHOP/β-actin: 0.456±0.189 vs. 0.361±0.134, appendix caspase-3/β-actin: 0.635±0.289 vs. 0.439±0.211, all P < 0.05]., Conclusions: The endoplasmic reticulum pathway JNK and CHOP pathways are involved in immune-related cell apoptosis and cytokine expression in mice with sepsis. Apoptosis is more obvious at 12 hours than at 6 hours, and the inflammatory response is stronger.

Objective: To observe the effects of Xiusanzhen treatment on the ultrastructure of olfactory bulb and the expression of substantia nigra glial fibrillary acidic protein (GFAP) in mice with Parkinson's disease (PD) induced by lipopolysaccharide (LPS), and to provide methods and evidence for early prevention and treatment of PD., Methods: Forty C57BL/6 male mice were randomly divided into a blank group, a model group, an electroacupuncture (EA) group and a medication group, 10 mice in each one. The mice in the model group, EA group and medication group were treated with 30-day nasal perfusion of LPS to establish PD model. From the first day of model establishment, the mice in the EA group were treated with electroacupuncture at bilateral "Yingxiang" (LI 20) and "Yintang" (GV 29) for 20 min, once a day; 5-day treatment was taken as one session, and 4 sessions were given with an interval of 2 days between sessions. The mice in the medication group were treated with intraperitoneal injection of L-DOPA, 10 mg/mL, once a day; 5-day treatment was taken as one session, and 4 sessions were given with an interval of 2 days between sessions. After treatment, the behavioristics changes were observed by using footprint analysis and swimming test score; the ultrastructure of olfactory bulb was observed by using transmission electron microscopy; the expression of GFAP in substantia nigra was measured by using western blot method., Results: ① After model establishment, the mice in the model group, the EA group and medication group showed significant symptoms of quiver and fear of chill, and the BMI was significantly lower than that in the blank group (all P <0.05). The results of behavioristics test indicated footprint length and swimming time in the model group, the EA group and medication group was significantly lower than those in the blank group (all P <0.01), indicating the successful establishment of PD model. ② After one-session treatment, the symptoms of quiver and fear of chill were not observed in the EA group. After 4-session treatment, the BMI in the EA group was significantly higher than that in the model group ( P <0.05); the symptoms of quiver and fear of chill were not observed in the medication group, but the BMI was similar with the model group ( P >0.05). ③ After treatment, the footprint and swimming time in the model group were significantly lower than that in the blank group (both P <0.01); the footprint and swimming time in the EA group and medication group were significantly higher than those in the model group (all P <0.01).④ After treatment, compared with the blank group, the organelles and ultrastructure of olfactory bulb in the model group were significantly improved; the ultrastructure of olfactory bulb in the EA group was improved compared with that in the model group. ⑤ After treatment, the expression of substantia nigra GFAP in the model group was significantly higher than that in the blank group ( P <0.01); the expression of substantia nigra GFAP in the EA group and medication group was significantly lower than that in the model group (both P <0.05)., Conclusion: The early treatment of Xiusanzhen can improve behavioral disorders in LPS-induced early PD mice, and the mechanism may be related to the regulation of olfactory disorders and the expression of GFAP in substantia nigra.

Objective: To investigate the value of micro- dissection testicular sperm extraction (micro-TESE) in the treatment of non-obstructive azoospermia (NOA) in patients with the history of secondary testicular injury., Methods: Totally, 121 NOA patients with the history of secondary testicular injury underwent micro-TESE in our hospital from September 2014 to December 2017. We analyzed the correlation of the sperm retrieval rate with the causes of testicular injury and compared the outcomes of the ICSI cycles with the sperm retrieved from the NOA males by micro-TESE (the micro-TESE group) and those with the sperm ejaculated from severe oligospermia patients (sperm concentration <1×10⁶/ml, the ejaculate group). Comparisons were also made between the two groups in the female age, two-pronucleus (2PN) fertilization rate, transferrable embryos on day 3 (D3), D3 high- quality embryos, D14 blood HCG positive rate, embryo implantation rate, and clinical pregnancy rate., Results: Testicular sperm were successfully retrieved by micro-TESE in 86.0% of the patients (104/121), of whom 98.4% had the history of orchitis, 75.5% had been treated surgically for cryptorchidism, and 63.6% had received chemo- or radiotherapy. No statistically significant differences were observed between the micro-TESE and ejaculate groups in the 2PN fertilization rate (59.4% vs 69.3%, P > 0.05), D14 blood HCG positive rate (44.6% vs 57.9%, P > 0.05), embryo implantation rate (31.8 %% vs 32.6%, P > 0.05) and clinical pregnancy rate (41.5% vs 48.7%, P > 0.05). However, the rate D3 transferrable embryos was significantly lower in the micro-TESE than in the ejaculate group (40.5% vs 52.2%,P < 0.05), and so was that of D3 high-quality embryos (32.5% vs 42.1%, P < 0.05)., Conclusions: Micro-TESE can be applied as the first choice for NOA patients with the history of secondary testicular injury, but more effective strategies are to be explored for the improvement of ICSI outcomes with the sperm retrieved by micro- TESE.

Objective: To investigate the effect of micro-dissection testicular sperm extraction (microTESE) for patients with non-obstructive azoospermia (NOA) and the indications of the strategy., Methods: This retrospective study included 196 cases of NOA undergoing microTESE in our center from September 2014 to March 2017. We recorded the sperm retrieval rate (SRR) and analyzed its correlation with the patients' age, testis volume, level of blood follicle-stimulating hormone (FSH), and etiological factors., Results: Testicular sperm were successfully retrieved from 87 (44.4%) of the patients. No significant correlation was found between the SRR and the patients' age, testis volume, or blood FSH level (P >0.05). As regards etiological factors, the SRR was 100% (29/29) in the patients with orchitis, 66.7% (16/24) in those surgically treated for cryptorchidism, 55.6% (10/18) in those with other secondary testis lesions, 60.0% (3/5) in those with AZFc deletion, 40.9% (9/22) in those with severe idiopathic testicular atrophy, 21.4% (12/56) in those with idiopathic NOA, 20.5% (8/39) in those with Klinefelter's syndrome, and 0% (0/3) in those with other abnormal karyotypes., Conclusions: MicroTESE is an effective strategy for sperm retrieval in NOA patients, and the SRR is correlated with etiological factors but not with the FSH level or testis volume of the patients.

Diabetic gastroparesis (DGP) is an important complication of diabetes, and seriously impacts the patient's quality of life. In the present paper, the authors summarize national and international research on the mechanism of acupuncture therapy in improving DGP and the pathogenesis of DGP over the past 10 years. The authors illustrate the mechanism of acupuncture underlying the improvement in DGP as follows:1) the effect on autonomic nerves and neurons of the central nervous system; 2) promoting restoration of the enteric nervous system; 3) the effect on Cajal interstitial cells; 4) improving gastrointestinal hormone disorder; 5) improving hyperglycemic state; 6) the effect on gastric smooth muscle. The authors also put forward some suggestions for future research on the mechanisms of acupuncture in DGP.

Racemic (±)-F18 (10-chloromethyl-11-demethyl-12-oxo-calanolide A), an analog of nature product (+)-calanolide A, is a new anti-HIV-1 nonnucleoside reverse transcript inhibitor (NNRTI). A successful enantioseparation of (±)-F18 offering (R)-F18 and (S)-F18 was achieved by a chiral stationary phase prepared HPLC. Their absolute configurations were determined by measurement of their electronic circular dichroisms combined with modem quantum-chemical calculations. Further investigation revealed that (R)-F18 and (S)-F18 shared a similar anti-HIV activities, however, (R)-F18 was more potent than (S)-F18 against wild-type virus, K101E mutation and P225H mutation pseudoviruses.