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Objective: To analyze the bibliometric indicators of SCI papers in the field of pharmacy in China from 2010 to 2019 by Essential Science Indicators (ESI) and InCites databases, so as to know the status quo and development trend of pharmacy in China in the last decade. Methods: In search of papers from ESI and InCites databases, the publication time of papers for retrieval was set within the time span of 2010-2019, the research output location was "mainland China" and the research area was "pharmacology and pharmacy". Then，related SCI papers in the field of pharmacy contributed by researchers in mainland China from 2010 to 2019 were retrieved. Such vital data as publication years, specific journals, location of research institutions, international collaboration and funding for researches were analyzed statistically, and those papers with high influential impact were further retrieved and analyzed. Results: In the field of domestic pharmacy，a total of 81 679 SCI papers were published, including 13 720 international collaborative papers and 470 papers with high influential impact. The amount of SCI papers，the number of international collaborative papers and papers with high influential impact increased year by year. China had international collaboration with 129 countries or regions in the field of pharmacy，and 48 .49% of the papers were sponsored by domestic research funds. Conclusion: In recent 10 years, the scope of research in pharmacy at home has expanded gradually, academic influential impact has arisen steadily, and the number of international collaborative papers and papers with high influential impact has also increased quite noticeably. However, the quality of scientific papers as well as international collaboration demand further improvement. [ABSTRACT FROM AUTHOR]

BACKGROUND: Exosomes have become one of the frontiers of biomedical research in recent years because of their promising applications in clinical diagnosis and therapy. OBJECTIVE: To reveal the basic research and technology development trend of exosomes at home and abroad, and provide suggestions for related scientific and technological research and development in China. METHODS: This paper presented a quantitative analysis of the overall research and development situation, the frontier hotspots and future development trends in this research area by means of bibliometric methods and tools. RESULTS AND CONCLUSION: The research and development hotspots in this area have entered a high growth phase with the application of new tools and methods. Many new technologies and products are facing clinical applications and markets with the development of a large number of clinical translation experiments. Comparative analysis at home and abroad reveals that China has made more remarkable achievements in basic research in this field, but there are still weaknesses in the possession of independent intellectual property rights, clinical technology translation, and regulatory system standardization and management, which need to be further strengthened in the future. [ABSTRACT FROM AUTHOR]

Objective The aim is to comprehensively understand the research status and application trends of oily drilling sludge at home and abroad. Methods Based on China National Knowledge Infrastructure (CNKI) and Web of Science (WOS) databases, this paper searched literature relating to oily drilling sludge research from 2007 to 2021, and adopted bibliometric method in analysis from multiple perspectives. Results The number of papers published in Chinese and English was rising from 2007 to 2021 while the former was higher than the latter. The funded projects with the largest number of publications globally were the National Natural Science Foundation of China. The influential institutions at home and abroad were China University of Petroleum (East China) and King Fahd University of Petroleum and Mineral Resources in Saudi Arabia. Researchers from China were highly active in this field, while the United States still takes the international leading position. Domestic research focused on drilling technology and petroleum sludge treatment, while studies aboard paid more attention to drilling materials and polluted water treatment. We also concluded that the studies on resource utilization of drilling mud was inadequate. Conclusions The resource utilization of oily sludge has become a research hotspot currently. Further, the harmless treatment and resource utilization of oily sludge for greening planting soil could be regarded as an important research and development direction. [ABSTRACT FROM AUTHOR]

BACKGROUND: Gastric cancer stem cells are a hot research topic in the medical field in recent years. Gastric cancer stem cells can interfere with the occurrence, metastasis, recurrence and drug resistance of gastric cancer. In theory, gastric cancer stem cells are the most promising candidate targets for the treatment of gastric cancer in the future. Therefore, studying the action mechanism of gastric cancer stem cells can not only elucidate the occurrence and development of gastric cancer, but also help to find new effective molecular targets, and has broad application prospects. OBJECTIVE: To summarize the hot spots and development trends of gastric cancer stem cells and to provide a reference for scientific researchers in related fields based on bibliometric and visualized analysis. METHODS: CiteSpace was employed to conduct the visualized analysis of annual publications, authors, countries, journals, citations and keywords of the related papers from 2011 to 2021 in the Web of Science Core Collection. RESULTS AND CONCLUSION: A total of 2 832 papers were included for analysis after screening. The annual publications increased rapidly, and the United States and China were the top contributors. Although the total number of papers published by Chinese researchers ranked the first in the world, the papers had low centrality and citation frequency, which indicated low quality and weak academic influence. Oncotarget was the journal with the largest number of articles published, and Oncology Letters was the journal with the largest number of articles published by Chinese researchers. Gastric cancer stem cells presented the trend of interdisciplinary development. The current studies about gastric cancer stem cells mainly focused on epithelial-mesenchymal transition; effect on biological function of gastric cancer cells and self-renewal. The plasticity of gastric cancer stem cells, the relationship with fatty acid oxidation and vascular endothelial growth factor, and the regulation of non-coding RNA on gastric cancer stem cells may be the focus of current and future research. The research of gastric cancer stem cells is currently in a rapid rise stage. In recent years, the action mechanism of gastric cancer stem cells is gradually clear. The treatment of gastric cancer stem cells will be a new targeted therapy strategy for gastric cancer patients in the future. [ABSTRACT FROM AUTHOR]

The concept of green agricultural development is an important basis for guiding agricultural transformation and upgrades with advances in China. Since its proposal, this concept has received extensive attention from researchers and the number of papers published on it has increased rapidly. We examined research papers related to green agricultural development published since 2016 and used a bibliometric method to comprehensively and systematically analyze research hotspots in green agricultural development. The hot topics for research in this field include：theory, policy mechanisms, evaluation, controlling agricultural non-point pollution sources, and the experience of developed countries. We propose future research directions based on an in-depth analysis of various hot research topics. These results provide a scientific reference for further studies of green agricultural development in China. [ABSTRACT FROM AUTHOR]

based on the Chinese Social Sciences Citation Index database, based on a sample of 1,179 papers on Tujia people in CSSCI from 2000 to 2021, this paper analyzes and summarizes the current situation and achievements of Tujia people research in the past 20 years in China. Over the past 20 years, experts and scholars have conducted extensive and in-depth re⁃ search on Tujia people from different perspectives, such as politics, economy, culture, religion, art, nationality and population, and published many high-quality academic papers. In order to understand more accurately and scientifically the current situa⁃ tion and development trend of domestic Tujia people studies since the 21st century, we carefully analyzed the main contents, subject words, basic viewpoints and research value of Tujia research papers in CSSCI database, and put forward the prospect of research prospect in Tujia people. [ABSTRACT FROM AUTHOR]

BACKGROUND: Femoroacetabular impingement syndrome is one of the main causes of hip pain, and there is a lack of research in the field of rehabilitation for femoroacetabular impingement syndrome in China. OBJECTIVE: To present the research trends and research hotspots in the field of femoroacetabular impingement syndrome rehabilitation based on the Web of Science and Citespace software in the form of scientific data combined with atlas and to analyze research prospects and propose future research directions. METHODS: Keywords regarding femoroacetabular impingement syndrome rehabilitation from 2012 to 2021 were searched in the Web of Science Core Collection, and the results were bibliometrically analyzed. Citespace software was then used to conduct visually analyze countries, institutions, authors, journals, keywords and co-cited references. Finally, research trends and hotspots in the past 10 years were summarized. RESULTS AND CONCLUSION: Femoroacetabular impingement syndrome rehabilitation has gradually attracted the attention of scholars and the number of publications and citations has increased yearly, with the United States taking the lead. Chinese scholars have published fewer papers in this field and only have cooperative relations with Australian and American scholars. China’s influence in this field needs to be improved. Keyword and literature co-citation burst analyses indicate that the research trends are gait function in patients with femoroacetabular impingement syndrome, clinical efficacy of non-surgical treatment/conservative treatment/physiotherapy for femoroacetabular impingement syndrome, and the efficacy of hip arthroscopy vs. non-surgical treatment. The high-frequency co-citations, high centrality and cluster analyses indicate that the research hotspots in this field are exploring the diagnosis of pain due to femoroacetabular impingement syndrome, the short-, medium-, and long-term clinical effects of non-surgical treatment vs. hip arthroscopy, the rehabilitation effect of physiotherapy, the applicability of self-report scales, the rehabilitation scheme of femoroacetabular impingement syndrome with cartilage injury or glenoid lip injury and paying attention to their rehabilitation process, preventing femoroacetabular impingement syndrome from progressing to osteoarthritis. Based on the analysis of relevant literature in the past 10 years, this review details the future research directions in this field, including explorations on the clinical efficacy of non-surgical/surgical treatment, the middle- and long-term efficacy of non-surgical treatment vs. surgical treatment, the concurrent loss of femoroacetabular impingement syndrome, and randomized controlled trials on the prognosis and rehabilitation of femoroacetabular impingement syndrome. [ABSTRACT FROM AUTHOR]

BACKGROUND: With the continuous accumulation of data resources around the world, the application of data visualization has become more urgent, and the methods of data visualization have also shown diversified characteristics. Data visualization is a scientific and technical research on the visual representation of data, which studies how to display relatively obscure data visually in a real and accurate way, to vividly and intuitively express the information and rules contained in the data. Literature is an important carrier of knowledge dissemination, with systematic characteristics, continuity, a large quantity and fast update, and is an important source of information. The visualization research of literature is of great significance to the dissemination of knowledge. At present, the visualization research of document data is mostly combined with the bibliometric analysis method, which visualizes the relationship between documents in the form of a scientific knowledge map. The application of this technology and method has played an important role in mining the information and rules contained in document data, but it is slightly insufficient in the spatial attribute mining of document data, which requires in-depth research in this field. OBJECTIVES: To provide new solutions for expanding the application of literature data in the field of spatial visualization, thereby further enhancing the usable value of literature data. METHODS: GIS technology was used to carry out the research on the spatial visualization method of document data, excavate the common content features and spatial features of document data, and gather the structured document data of a certain volume of spatial feature information to lay the data foundation for the visualization research. At the same time, the combination point between GIS technology and document data was studied, and the strategy and technical route for information mining and spatial visualization of document data were formed. Taking the data of more than 140 Re-Os isotope dating documents published since 2015 to 2020 as an example, the application test of this technical method was carried out. A Re-Os isotope data visualization service system with a five-tier architecture including layers of support, data, service, application and user has been developed, to realize the spatial visualization application of Re-Os isotope dating document data results. RESULTS: The results show that: (1) The study area contains more than 140 ore producing areas that carried out Re-Os isotope dating research from 2015 to 2020, covering the eastern, central, and western regions of China. (2) There are 19 main minerals in the study area, mainly copper (29. 0%), molybdenum (28. 3%), tungsten (12. 4%) and gold (11. 0%). (3) There are 12 kinds of detection objects, and the proportion of molybdenite as the detection object is 80. 7%, which indicates that molybdenite is still the preferred research object of the Re-Os isotope dating method, which is inseparable from the high Re / Os value of molybdenite. (4) The detection age falls in the lower age range of 0 - 200Ma, accounting for 62. 1% of the ore - producing areas, which are mainly distributed in the northeast and southeast regions of China, indicating that the Re-Os isotope ages in the eastern region are concentrated in the Mesozoic era, which is consistent with the existence of large - scale Mesozoic mineralization events in the eastern region of China. The ore - producing area in the age range above 200Ma accounts for 37. 9%, which is mainly distributed in the central and western regions of China, indicating that the Re-Os isotope ages in the central and western regions are concentrated before the Mesozoic era and have the characteristics of multiple mineralization. CONCLUSIONS: The research shows that the document data visualization technology and method proposed in this paper can be used to excavate the spatial characteristics of the document data, expand the application of the document data in the field of spatial visualization, and solve the problems of how to analyze and extract the common information of the document data, locate the spatial feature information, and realize the spatial visualization technology. In terms of revealing important target areas, key research minerals and main application technologies, it can provide spatial visualization information, and provide reference for finding the hot spots and difficulties of current metallogenic chronology research. [ABSTRACT FROM AUTHOR]

Objective: To make a bibliometric analysis of the literature published in Pharmaceutical Cave and Research from 2001 to 2021 and study its academic influence. Methods: The literature published since December 2001 was retrived from the website of Pharmaceutical Cave and Research (http://pcarjournal.zgkw.cn). All the information concerning publication time distribution, author affiliations, citation frequency, key words and fund sponsorship were collected for statistical analysis. The top 10 author affiliations and top 20 frequently-cited papers were screened. The expansion of the geographical coverage and increase of academic influence of the journal were analyzed. The key words with frequency ≥15 times in pharmaceutical care papers were identified. The Ucinet 6.0 software and NetDraw software were used to plot the network relationship diagram of high frequency key words and find out the hotspots of the pharmaceutical care papers in the journal. Results: Since inception, the Journal has totally published 3021 papers, reached peak in 2008-2010 and then gradually declined. Now, the journal enjoys a good reputation in Shanghai and even in the whole Eastern part of China, with author affiliations distributing throughout 33 provinces, municipalities directly under the central government and autonomous regions, and even with a few of foreign contributors. There were 1446 papers cited by the Chinese science and technology core journals, and 183 papers cited by SCI journals. Totally, 596 fund-sponsored papers were published in the journal, with the ratio of fund-sponsored papers accounting for 19.73%. The pharmaceutical care papers published in the journal clearly displayed the development process of pharmaceutical care in China. Conclusion: With good academic quality, this journal has high influence in the field of pharmacy, particularly in pharmaceutical care. In addition it provides a high level academic exchange platform and professional support for the development of pharmaceutical care, and plays a positive role in promoting further development of hospital pharmacy. [ABSTRACT FROM AUTHOR]

BACKGROUND: Mesenchymal stem cells have the characteristics of self-renewal and multi-directional differentiation, and have great potential and application prospects in the treatment of intervertebral disc diseases. OBJECTIVE: To analyze the literature of mesenchymal stem cells in the treatment of intervertebral disc degenerative diseases using bibliometric analysis, and to understand the research trends and hotspots in this field, and to provide basis and suggestions for its follow-up development. METHODS: With the theme of mesenchymal stem cell therapy for intervertebral disc degeneration, we searched the relevant literature included in the Web of Science database from 2000 to 2019, analyzed the annual number of paper published, and scientific research funding. Citespace5.5.R2 software was used to analyze the cooperation relationship of authors, countries and research institutions, the co-citation of journals or literatures. Finally, cluster analysis, burst analysis and time zone graph analysis were performed on keywords. RESULTS AND CONCLUSION: (1) A total of 648 papers were included, with journal articles as the main type of literature. (2) Most of the funding were sponsored by China and USA (more than 50%). (3) A total of 206 authors were included, out of whom 70 authors published more than 3 papers, and the principal researchers were Daisuke Sakai (Japan) focusing on mesenchymal stem cells transplantation for intervertebral disc degeneration, Judith A Hoyland (Great Britain) focusing on regulation of myeloid cell phenotype by mesenchymal stem cells, and Makarand V Risbud (US) focusing on induction of mesenchymal stem cell differentiation. (4) 125 countries and institutions were included: China and USA were the two main countries. (5) 154 journals were included, as SPINE was the journal with the most published articles. (6) The keyword analysis showed that the research in this field can be divided into three phases: phase 1 from 2005 to 2012, mainly investigating gene expression differences, chondrogenic differentiation of mesenchymal stem cells, and extracellular matrix changes in the intervertebral disc; phase 2 from 2012 to 2017, mainly investigating mesenchymal stem cell injection therapy and changes in the microenvironment of the intervertebral disc; phase 3 from 2017 to 2019, the main study is cell therapy and disc regeneration promoted by mesenchymal stem cells. (7) The probably research direction was to extract mesenchymal stem cells and induce their differentiation to nucleus pulposus, paracrine secretion of mesenchymal stem cells on the function of disc cells and mesenchymal stem cells combined with tissue engineering technology to promote intervertebral disc regeneration. [ABSTRACT FROM AUTHOR]

Background and objective: Cardio-oncology that focuses on the management of cardiovascular toxicity associated with cancer therapy, has grown rapidly worldwide as an emerging interdisciplinary discipline over the past decade. This study aimed to summarize the hot spots and development trends of cardio-oncology to provide a reference for scientific researchers in related fields based on bibliometrics. Methods: CiteSpace was employed to conduct the visualized analysis of annual publications, authors, countries, citations and keywords of the related papers from 2012 to 2022 in the Web of Science Core Collection and China National Knowledge Infrastructure (CNKI). Results: A total of 4 287 English articles and 1 165 Chinese articles were included after screening. At present, the number of foreign literature in the field of cardio-oncology, showed a trend of rapid growth, while our country has "slow development period" and "rapid development period" with 2016 as the boundary. The United States is the country with the largest number of publications in Web of Science, accounting for about 34.21% of the total, followed by China, Italy and other countries. The institutions with the largest number of publications at home and abroad are the University of Texas MD Anderson Cancer Center and the First Affiliated Hospital of Dalian Medical University. Bonnie KY, Ana Barac, Paaladinesh Thavendiranathan are the main contributors abroad, and Xia Yunlong, Zhang Yuhui and Cheng Leilei are the main contributors in China. The most frequently cited literature is the position statement on cancer treatment and cardiovascular toxicity from the European Society of Cardiology. The most frequently used keywords abroad were "heart failure", "breast cancer" and "cardiotoxicity", while the most frequently used keywords in China were "cardiotoxicity", "cardiac tumor" and "doxorubicin". Keywords with the strongest citation bursts at home and abroad in recent three years are "immune checkpoint inhibitors". Conclusion: The research hotspots mainly focus on cardiotoxicity caused by antineoplastic therapy, prevention and treatment, screening and diagnosis of cardiovascular toxicity associated with cancer therapy, etc. Establishing a multidisciplinary diagnosis and treatment model and paying attention to the immune checkpoint inhibitor-related myocarditis and whole process management of cardio-oncology are the directions of future development. [ABSTRACT FROM AUTHOR]

：Household air pollution（HAP）from the indoor burning of solid fuels, such as coal and biomass fuels, directly affects human health. Global exposure to HAP is estimated to cause millions of premature deaths. To better understand the research progress and hotspots of HAP studies, a bibliometric analysis was carried out using CiteSpace and papers searched from the Web of Science Core Collection. The number of publications per year, publication journals, and keywords was analyzed. The results showed that the number of publications in this field is growing exponentially, indicating that this issue is receiving more interest. These studies are mostly published in international journals such as Indoor Air, Science of the Total Environment, and Energy for Sustainable Development, with research teams from countries such as the United States and China. Clean energy, improved cookstoves, black carbon, and PM2.5 are the most widely mentioned keywords. Health outcomes of HAP exposure, clean intervention, and co-benefits in health and climate are important foci. It is suggested that sequential studies should be conducted on pollution characterization, exposure, and health risk assessment to protect human health. [ABSTRACT FROM AUTHOR]

BACKGROUND: The treatment of stem cells in intervertebral disc degeneration has always been a research hotspot. It is possible to predict and analyze the research status and development trend of this field to a certain extent, applying bibliometric analysis software to perform co-occurrence and co-citation analysis of numerous literature data in this field. OBJECTIVE: To analyze research status and development trend of stem cells in the treatment of intervertebral disc degeneration by bibliometric visualization analysis. METHODS: The authors retrieved the literature on stem cells in the treatment of intervertebral disc degeneration from 1999 to 2020 through the core collection of Web of Science, and used bibliometrics methods to conduct statistical analysis on the literature data, combined with Citespace 5.6.R5 and VOSviewer 1.6.15 software to transform the visualization atlas, analyze the research status and development trend of stem cells in the treatment of intervertebral disc. RESULTS AND CONCLUSION: (1) A total of 613 articles were included. The number of publications of stem cells in intervertebral disc treatment research is increasing year by year. Among them, China and the United States rank first and second with 232 and 174 publications respectively. (2) The United States has a total citation frequency (5 522), h index (42), and betweenness centrality (0.75) ranks first, both higher than the second place in China (3 169, 28, 0.16). (3) The top ten cited references introduced the research on the treatment of intervertebral disc degeneration with microscopic mesenchymal stem cells from various aspects, and seven of them were related to nucleus pulposus like differentiation of bone marrow mesenchymal stem cells. Two papers are related to the best cell source and cell carrier generation in the treatment of intervertebral disc regeneration. One is related to the clinical trial study of the treatment of degenerative disc regeneration. (4) The timeline chart of reference co-citation shows that the most references are published in clusters of “Mesenchymal Stem Cells”, “Notochord Cells”, “End Plates”, and “Adipose derived Mesenchymal Stem Cells”. From a year of publication perspective, the clustering “notochord cells”, “notochord”, and “injection” published in the latest year. (5) Clustering keywords “intervertebral disc degeneration”, “migration”, “notochord cells”, “genipin” and “hydrogel” correspond exactly to the above. It was confirmed that the keywords suddenly appeared and found that present research hotspots are: mesenchymal stem cell nucleus pulposus-like differentiation, the best cell source in the treatment of intervertebral disc regeneration and the clinical effectiveness and biosafety of cell carrier construction and intervertebral disc regeneration treatment. (6) There are five new keywords from 2017 to 2019, namely “injection”, “intervertebral disc degeneration”, “inflammation”, “apoptosis”, and “puncture”, mainly focusing on cell apoptosis, inflammatory reaction, intervertebral disc regression, and cell transplantation methodology. (7) The above-mentioned global trend analysis suggests that as the amount of stem cells published in the treatment of intervertebral disc degeneration continues to increase, related research is also constantly deepening. The current research focuses on the nucleus pulposus-like differentiation of mesenchymal stem cells, the best cell source and cell carrier integration in the treatment of intervertebral disc regeneration, and the clinical effectiveness and biological safety of integration of intervertebral disc regeneration treatment. In-depth exploration of the mechanism of intervertebral disc degeneration and inflammatory response and improvement of cell transplantation methodology are the focus of future research. [ABSTRACT FROM AUTHOR]