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T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive tumor, in which T precursor cells undergo malignant transformation, and the side effects and drug resistance of chemotherapy drugs are still difficult problems hindering the success of treatment. Vincristine (VCR) is a traditional chemotherapy drug for children with significant efficacy in T-ALL, but its side effects are obvious. Lithium carbonate (Li2CO3) can enhance the efficacy of other chemotherapy drugs, but studies of its combination with VCR have not been reported. The purpose of this study is to investigate the effects of Li2CO3 combined with VCR on the proliferation, apoptosis and cell cycle of two pediatric T-ALL cell lines, CCRF-CEM and Jurkat cells. The results of thiazolyl blue tetrazolium bromide (MTT) colorimetric assay showed that the viability of both cells decreased with the increase of the concentration of VCR or Li2CO3 alone, which compared with the control group (P<0.05). The survival rates of the two kinds of cells were different under the same Li2CO3 concentration (P<0.01). Compared with the VCR group, the cell viability and half maximal inhibitory concentration (IC50) values of Li2CO3 combined with VCR group were reduced in the two kinds of cells, and the coefficient of drug interaction (CDI) between Li2CO3 and VCR was less than 1. Flow cytometry showed Li2CO3 combined with VCR group had the highest proportion of G2/M and apoptotic cells of the two kinds of cells among the control, Li2CO3, VCR and, Li2CO3 combined with VCR group. And there were significant differences between Li2CO3 combined with VCR group and VCR group (P<0.05). In conclusion, our experimental results suggest that the combination of Li2CO3 and VCR inhibits of T-ALL cell proliferation, arrests the cell cycle in the G2/M phase and increases cell apoptosis, which provides a new experimental basis for the clinical treatment of pediatric T-ALL, the reduction of VCR side effects, and also new ideas for drug development. [ABSTRACT FROM AUTHOR]

To investigate the effect of lithium carbonate(Li2 CO3 ) and ultrafine mineral admixture(UMA) on the performance of fast-hardening sulfoaluminate cement (R·SAC). The effects of Li2 CO3 and UMA on the setting time, mechanical properties, hydration product types and microscopic morphology of R·SAC were investigated based on X-ray diffraction (XRD) and scanning electron microscope (SEM) tests with setting time and mechanical properties as macroscopic indicators. The results show that Li2 CO3 can not only effectively improve the generation rate of Aft, the main hydration product of R·SAC, but also change its microscopic morphology and significantly shorten the setting time of R·SAC. Although Li2 CO3 changes the hydration process of R·SAC, it has no effect on the types of hydration products. UMA can not only improve the academic properties of the transition zone force at the interface of R·SAC colloidal sand, but also effectively shorten the setting time of R·SAC. And it can also effectively shorten the setting time of R·SAC, and at the same time play a compensating role in the later strength inversion of the colluvium. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To explore the influencing factors of drug concentration / dose ratio (C / D) in patients with depression after taking sertraline, so as to provide reference for the clinical individualized medication of sertraline. METHODS: Retrospective analysis was performed on 529 drug concentration monitoring data from 373 patients with depression who received sertraline therapy monitoring in the Affiliated Brain Hospital of Guangzhou Medical University from 2019 to 2020. Data such as gender, age, body mass index ( BMI), frequency of administration and drug combination were entered into the table. SPSS 23. 0 software was used for statistical analysis of the above data. RESULTS: BMI and administration frequency had significant effects on C / D of sertraline (P<0. 05). The C / D of sertraline in the combined olanzapine group was significantly higher than that in the non-olanzapine group (P<0. 05). The C / D of sertraline in the combined lithium group was significantly higher than that in the non-lithium group (P< 0. 01), the differences were statistically significant. In the multiple linear regression analysis model, the effects of dose, frequency of administration and drug combination of olanzapine or lithium on blood concentration of sertraline were statistically significant. CONCLUSIONS: The influencing factors of blood concentration of sertraline are complex and have a great relationship with the dosage. The results of this study suggest that the drug combination of olanzapine or lithium may require dose adjustment of sertraline. [ABSTRACT FROM AUTHOR]

When lithium was produced in the process of aluminothermic reduction LiAlO2 clinker in vacuum condition where the clinker was prepared by calcined mixture of lithium carbonate， alumina and calcium oxide at normal atmosphere， the reduction residue containing CaO·Al2O3 and 12CaO·7Al2O3 was obtained. In order to recycle the reduction residue， the residue was firstly leached with a mixture solution of sodium hydroxide and sodium carbonate， and then aluminum hydroxide was produced by decomposing the leaching solution with carbon dioxide. The effects of leaching temperature， leaching time， particle size， sodium carbonate concentration， sodium hydroxide concentration and lithium reduction rate on leaching rate of alumina were investigated. The results showed that the leaching rate of alumina is 80.73% under the conditions of the particle size distribution d90 of 74μm，the leaching temperature of 95°C， the leaching time of 120min， the Na2CO3 concentration of 240g/L and NaOH concentration of 8.9g/L， when the residue is from the reduction lithium process with a reduction rate of 97%. The average particle size and the whiteness of aluminum hydroxide obtained by carbonation precipitation are 6.50μm and 96.9， respectively. [ABSTRACT FROM AUTHOR]

Since great breakthrough was made in purifying lithium carbonate from brine with high content of magnesium and low content of lithium, extracting lithium from brine has obtained increasing attention in China. Potassium-rich brine in the northeastern Sichuan contains many kinds of rare metals such as lithium which is urgently demanded in strategic emerging industries, while associated lithium resources of potassium-bearing brine are rarely considered in previous studies. A borehole(ZK001)with the depth of 3 227 m was arranged in deep exploration project in Xuanhan area of the northeastern Sichuan, of which the main goal is to investigate lithium-bearing brines in the deep. Analysis of fluids during drilling(conventional circulating drilling gas)is a main method of conventional real-time monitoring of wellhead fluids. As a result of lithium’s active property, it is difficult to reveal enrichment features of lithium by gas component only. Fluids of borehole ZK001(include deep brine, fluids during drilling, drilling-washing water), surface water and groundwater around borehole ZK001 were collected and analyzed; the characteristics of fluids during drilling were obtained for the first time; and the vertical variations of lithium and other components of drilling fluids in borehole ZK001 were summarized. The lithium concentrations in different types of water around borehole ZK001 show a rule that deep brine, drilling-washing water, fluids during drilling, groundwater, and surface water in descending order. By comparing the profile characteristics of the composition of fluids during drilling in borehole ZK001, it is discovered that lithium concentration of fluids during drilling in the depth of 0-500 m is relatively high while the ratio of Mg/Li is low. It is revealed that lithium concentration of fluids during drilling is proportional to the depth, and the ratio of Mg/Li is inversely proportional to depth. Lithium concentration of yellow brine collected at the depth of 3 000 m from borehole ZK001 is 10 556 μg·L-1(the ratio of Mg/Li is 33.92), which almost reaches the half of the cut-off grade(24 599 μg·L-1). In addition, Na, K, Rb, Sr components of the yellow brine from borehole ZK001 reach industrial grade. These features of fluids from borehole ZK001 will provide scientific support for future arrangement in drilling engineering. [ABSTRACT FROM AUTHOR]

The variations of cathode liquid pH and temperature and the phase composition and microstructure of Li2CO3 products were studied during the electrolytic process when the anolyte concentration was 300g/L and catholyte concentration were 50， 100， 200， 300 and 400g/L， respectively. The results show that the concentration or concentration difference has little effect on the reaction mechanism in the electrolysis process， while the concentration difference has a great influence on the speed and the limit of the reaction. The amount of Li2CO3 products and current efficiency increase with the decrease of the concentration difference or concentration of catholyte. The crystallography of Li2CO3 produced from electrolysis is monoclinic. Moreover， the concentration difference not only increases the crystallization degree of Li2CO3 products but also refines the grains. The optimal catholyte concentration of LiCl as the electrolytic parameter is 100g/L， ie， the concentration difference between anode and cathode liquid is 200g/L. [ABSTRACT FROM AUTHOR]

Objective To explore the efficacy and clinical value of 131I combined with lithium carbonate in the treatment of Graves' disease with leucocytopenia. Methods Patients (n=348) were randomly divided into two groups. Experimental group (n=178) were treated with 131I plus lithium carbonate; Control group (n=170) were only treated with 131I. Recovery rate, effective rate, thyroid 131I uptake rate, the level of thyroid hormone (free triiodothyronine, FT3 and free thyroxine, FT4)and peripheral blood leukocyte were analyzed retrospectively. Results The recovery rate of the experimental group (87.6%)is significantly higher than that in the control group(71.8%) . But the effective rate of the experimental group (97.8%)is not significantly different to that in the control group(94.1%) . The 131I 24 h uptake rate in the experimental group(69.75±6.79)is higher than that in the control group (44.27±3.27) after the treatment of lithium carbonate. The level of thyroid hormone (FT3, FT4) in the experimental group are significantly lower than that before treatment after 2 weeks, 1 months. However, the levels of thyroid hormone (FT3, FT4) in the control group are higher than that before treatment after 2 weeks and began to decrease after 1 month. The treatment of experimental group contribute to the fast improvement of peripheral blood leukocyte level. The level of peripheral blood leukocyte was significantly higher than that before treatment after 3 months(P<0.01) . Conclusion The treatment of lithium carbonate combined with 131I for Graves' disease with leukopenia is safe and effective. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To probe into the clinical efficacy and safety of lithium carbonate combined with clozapine in treatment of mania. METHODS: 120 patients with mania admitted into Nanyang Central Hospital from May 2013 to Aug. 2015 were selected to be divided into observation group and control group via the random number table, with 60 cases in each. The control group were treated with lithium carbonate, while the observation group received lithium carbonate combined with clozapine, the treatment course were 8 weeks. The treatment efficacy and adverse drug reactions were compared between two groups. RESUKTS: After treatment, in the observation group, the Bech-Rafaelsen mania rating scale and TESS scale score were significantly lower than those in the control group; the average and median onset time, symptom alleviating time were significantly shorter than those in control group, and indicators as blood glucose, blood lipid and body mass were significantly better than those in control group, with statistically significant difference (P<0.05). CONCLUSIONS: The efficacy of lithium carbonate combined with clozapine in treatment of mania is remarkable, with few adverse drug reactions and high safety. It is worthy of promotion and application. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To probe into the clinical efficacy of magnesium valproate combined with clonazepam in treatment of mania. METHODS: 70 cases with mania admitted into Qiqihaer Mental Health Center from Sept. 2013 to Sept. 2014 were selected to be divided into two groups via the random number table, with 38 cases in each. The observation group were treated with magnesium valproate therapy combined with clonazepam, while the control group received lithium therapy; after treatment, the onset time of drug were evaluated by bech-rafaelsen (BRMS); before and after treatment of 1, 2, 4, 6weeks, BRMS scores, efficacy and adverse reactions were recorded. RESULTS: After treatment of 1 week, BRMS scores of observation group were (1.61 ± 1.3) scores, of control group were (17.2 ± 1.5) scores; after treatment of two weeks, observation group were (12.2 ± 1.3) scores, control group were (14.6 ± 1.7) scores, the difference was statistically significant different between two groups (P < 0.05). After treatment of 4 weeks and 6 weeks, the data in observation group were respectively (9.8 ± 2.0) scores and (7.1 ± 1.2) scores, in control group were (12.9 ± 2.1) scores and (10.3 ± 2.3) scores, without statistically significant difference (P > 0.05). The effective rate of observation group was 84.2% (32 /38), of control group was 78.1% (25 /32), without statistically significant difference (P > 0.05). There were 4 cases of sleepiness, a case of nausea in observation group; and 8 cases of sleepiness, a case of nausea, 2 cases of weight gain and 1 cases of electrocardiographic abnormality in control group; the difference was statistically significant (P < 0.05).CONCLUSIONS: The effect of magnesium valproate combined with clonazepam in treatment of mania is significant, with few adverse reactions, which is safe, reliable and worthy of clinical application. [ABSTRACT FROM AUTHOR]