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Broflanilide, a negative allosteric modulator of γ-aminobutyric acid (GABA)-gated chloride channel, is a novel diamide insecticide. It was mainly used for the control of lepidoptera and coleopteran pests at present, and it also exhibited high insecticidal activity against termites and flies. In this paper, the structure type, research process, mechanism of action, insecticidal activities, safety, and metabolic residue of broflanilide were mainly reviewed. Moreover, its development and application trends were also prospected. [ABSTRACT FROM AUTHOR]

In order to discover insecticide leads with novel structures, a variety of cyclopropanecarboxylic acid-containing active fragments were introduced into diamide insecticides. 21 novel diamide derivatives were designed and synthesized. Their structures were characterized by nuclear magnetic resonance spectroscopy (NMR) and high resolution mass spectrometry (HRMS). And their biological activities against Aphis craccivora, Mythimna separate, Fusarium graminearum and Blumeria graminis were evaluated. The results suggestted that most of our anthranilic diamides had low fungicidal activities on the two fungi and good insecticidal activities against the two insect targets. And at the concentration of 500 mg/L, 10h exhibited a mortality rate of 90% against A. craccivora, while 10k possessed a rate of 100% against M. separate. Both two derivatives could be further optimized as potential insecticide leads. [ABSTRACT FROM AUTHOR]