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Copyright of Psychological Science is the property of Psychological Science Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To observe the efficacy of Dingxin decoction combined with paroxetine in the treatment of generalized anxiety disorder(GAD) of liver depression transforming into fire type and its effect on serum neurotransmitter levels. Methods From June 2021 to June 2023, a total of 80 patients with GAD of liver depression transforming into fire type diagnosed and treated in our hospital were selected and randomly divided into two groups, namely the observation group (Dingxin decoction combined with paroxetine hydrochloride treatment, n=40) and the control group (paroxetine hydrochloride treatment, n=40). The efficacy of the two groups was observed, and the scores of Hamilton Anxiety Scale(HAMA) and TCM symptoms in the two groups were recorded. The levels of serum norepinephrine (NE), 5-hydroxytryptamine (5-HT), glutamic acid (Glu), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in the two groups were detected, and the incidence of adverse reactions in the two groups was compared. Results In terms of efficacy, the observation group had a greater advantage, and the total effective rate was higher than that of the control group, the difference was statistically significant (P<0.05). After treatment, the HAMA score and TCM symptom score of the two groups were significantly lower than those before treatment.and the observation group was lower than the control group, the differences were statistically significant (P<0. 05). After treatment, the levels of NE and Glu in the two groups were lower than those before treatment, and the level of 5-HT was increased. The levels of NE and Glu in the observation group were lower than those in the control group and the level of 5-HT was higher than that in the control group (P<0.05). After treatment, the levels of CRP, TNF-α and IL-6 in the two groups were significantly decreased.and those in the observation group were lower than the control group, differences being significant (P<0.05). The total incidence of adverse reactions in the observation group and the control group was 17.50% and 25.00%, respectively. There was no significant difference in the total incidence of adverse reactions between the two groups (X² = 0.672, P=0.412). Conclusion Dingxin decoction combined with paroxetine can effectively alleviate the somatic and mental anxiety symptoms of GAD patients with liver depression transforming into fire type, regulate the level of neurotransmitters, reduce the level of inflammation.and have no serious adverse reactions and high safety. [ABSTRACT FROM AUTHOR]

Objective To explore the relationship between social media addiction and anxiety among college students and the role of bedtime procrastination and stress perception. Methods A total of 15493 college students were selected by convenience sampling in September 2023 with using the Bergen Social Networking Addiction Scale, the Bedtime Procrastination Scale, the Chinese Perceived Stress Scales and the Generalized Anxiety Disorder 7-item Scale. SPSS25.0 macro program PROCESS was used to analyze the mediating effect of bedtime procrastination and the moderating effect of stress perception. Results The social media addiction was positively predicted college students' anxiety (β=0.307, P＜0.001). Bedtime procrastination partially mediated the relationship between social media addiction and anxiety in the college students. The mediation effect value was 0.060 (95% Bootstrap CI=［0.055-0.065］), the mediating effect accounted for 19.54% of the total. Stress perception moderated the relationship between bedtime procrastination and anxiety (β=0.094, P＜0.001). As the level of perceived stress increased, the positive association between bedtime procrastination and anxiety became stronger. Conclusion Social media addiction can directly affect anxiety in the college students, or indirectly affect it through bedtime procrastination, and perceived stress moderates the path from bedtime procrastination to anxiety in the mediation model. [ABSTRACT FROM AUTHOR]

To explore the mediating effect of sleep duration on the relationship between qi stagnation constitution and anxiety/depression in junior high school students. Methods From March 20 to March 31, 2020, a total of 10, 325 students from 6 junior high schools in Henan, Liaoning, Shaanxi, Shandong, and Fujian provinces were sampled by cluster sampling. Firstly, the general conditions ( age, gender, grade, hometown, whether they are an only child) and sleep duration were collected, and their qi stagnation constitution, depression and anxiety status were evaluated by using the Qi Stagnation Subscale in the "' TCM Constitution Classification and Judgment Scale", the Patient Health Questionnaire (PHQ-9) and the Generalized Anxiety Disorder ( GAD-7). Secondly, Spearman correlation analysis was used to explore the correlation between qi stagnation constitution, sleep duration, and anxiety/ depression. Then, linear regression analysis and mediating effect test were used to explore the relationship between qi stagnation constitution and anxiety/depression in junior high school students, and the mediating effect of sleep duration was analyzed, and the results were verified. Results (i) The detection rate of anxiety in non-only children was higher than that of only children (X1 = 11. 198, P = 0. 001) ； The detection rate of anxiety (f = 106. 967, P<0. 001) or depression (f = 84. 692, P<0. 001) was higher among senior students than those in lower grades, while those of girls with anxiety = 100.441, P<0.001) or depression (太2 = 71.418, P <0.001) were higher than those of boys. The detection rates of anxiety (太2 = 1 092. 298, P<0. 001) and depression (X1 = 866. 740, P<0. 001) in qi stagnation constitution students were higher than those of non-qi stagnation constitution students, and the detection rates of anxiety (χ2 = 1 076. 716, P<0. 001) and depression (太2 = 1 099. 725, P<0. 001) in students whose sleep duration less than 8 h were higher than those of whose sleep duration more than 8 h, and the shorter the sleep duration, the higher the detection rate. (ii) Qi stagnation constitution positively predicted anxiety/depression (β = 0.679, P<0.001;β = 0.718, P<0.001), and sleep duration had a negative predictive effect on anxiety/depression (β = -0.403, P<0. 001 ；β = -0. 439, P<0.001). ( iii) Sleep duration played a partial mediating role in the relationship between qi stagnation constitution and anxiety/depression in junior high school students, and the mediating effect accounted for 13. 40% and 13. 79% of the total effect, respectively. Conclusion Although qi stagnation constitution mainly affects anxiety/depression through direct effect, it can still be partially indirectly realized through the mediating variable of sleep duration, that is, the shorter the sleep duration, the higher the risk of anxiety/depression in junior high school students. Therefore, the mental health problems of junior high school students can be prevented and improved by regulating qi stagnation constitution and ensuring adequate sleep duration. [ABSTRACT FROM AUTHOR]

Objective To observe the effects of 20 Hz repetitive transcranial magnetic stimulation (rTMS) combined with venlafaxine in the treatment of adult generalized anxiety disorder (GAD) and its impact on cognitive function and negative emotions. Methods A total of 75 adult patients with GAD admitted to the hospital from March 2021 to April 2023 were randomly divided into two groups using the random number table method. The control group (37 cases) received venlafaxine treatment, while the study group (38 cases) received rTMS on the basis of venlafaxine. The clinical efficacy of the two groups was compared. Results The total effective rate eye movement measurement. Montreal Cognitive Assessment Scale (MOCA) scores in the study group were higher than those in the control group and the event-related potential latency, as well as the scores of GAD-7 scale, Hamilton Anxiety Scale and Hamilton Depression Scale were significantly lower than those of the control group, with statistical significance (P<0.05). Conclusion The 20 Hz repetitive transcranial magnetic stimulation combined with venlafaxine therapy can improve the clinical efficacy, cognitive function, and alleviate negative emotions in adult patients with GAD, with high therapeutic practicality. [ABSTRACT FROM AUTHOR]

Copyright of West China Journal of Stomatology is the property of Sichuan University, West China College of Stomatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Sichuan University (Medical Science Edition) is the property of Editorial Board of Journal of Sichuan University (Medical Sciences) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BackgroundPrevious studies have found that patients with generalized anxiety disorder （GAD） have impaired performance in executive function， and group cognitive behavioral therapy （CBT） has been shown to be effective in alleviating negative affect in patients with GAD， while its efficacy on executive function remains unclear.ObjectiveTo explore the efficacy of group CBT on anxiety symptom and executive function in GAD patients， so as to provide references for the rehabilitation program for GAD.MethodsA total of 80 consecutive patients with GAD who were hospitalized in Sleep and Psychosomatic Medical Center of Shiyan Taihe Hospital from March 2021 to August 2022 and met the Diagnostic and Statistical Manual of Mental Disorders， fifth edition （DSM-5） diagnostic criteria for GAD were enrolled， and they were assigned into study group （n=40） and control group （n=40） using random number table methods. All patients were subjected to routine medication treatment and regular health education， based on this， study group received group CBT once a week （6 weeks， 60 to 90 minutes per session）. At the enrollment and after 6 weeks of treatment， patients were assessed using Hamilton Anxiety Scale （HAMA） and Frontal Assessment Battery （FAB）.ResultsANOVA with repeated measures on HAMA score revealed a significant time effect （F=1 870.320， P0.05）. Significant time effect， group effect and time×group interaction effect were reported on FAB scores （F=311.190， 4.399， 7.021， P

Objective To evaluate the clinical efficacy and safety of soothing the liver and regulating the mind in the treatment of primary breast cancer complicated with generalized anxiety disorder, and to explore its immune mechanism. Methods A randomized controlled study was conducted to include patients who met the inclusion criteria in Guang'anmen Hospital, China Academy of Chinese Medical Sciences from August 2022 to February 2023. According to the 1: 1: 1 random principle, patients were divided into three groups: the traditional Chinese medicine group(n=30), the auricular acupuncture group(n=30), and the control group (n=28). The three groups all received Western medicine standard treatment. On the basis of Western medicine standard treatment, the traditional Chinese medicine group received modified prescriptions for soothing the liver and regulating the mind, and the auricular acupuncture group received auricular acupuncture therapy for soothing the liver and regulating the mind. The course of treatment was 8 weeks. The scores of Hamilton Anxiety Scale (HAMA), Self-rating Anxiety Scale (SAS) and World Health Organization Quality of Life-BREF (WHOQOL-BREF), and the contents of interleukin(IL)-1β, IL-8, IL-10, IL-6, IL-2, IL-4, interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α) were evaluated before and after treatment among the three groups. The HAMA score reduction rates of the three groups after treatment were calculated, and the total effective rates were compared. Results After treatment, the HAMA, SAS, and WHOQOL-BREF family friction scores in the traditional Chinese medicine group and the auricular acupuncture group were all lower than those before treatment (P<0.05), and the WHOQOL-BREF physiology dimension, social dimension, environment dimension, and self-assessment scores were higher than those before treatment (P<0.05). There were significant differences in HAMA, SAS, and WHOQOL-BREF physiology dimension, social dimension, environment dimension, self-assessment, and family friction scores among the three groups after treatment (P<0.05). The scores of HAMA, SAS and WHOQOL-BREF family friction in the traditional Chinese medicine group were lower than those in the control group, while the scores of WHOQOL-BREF physiology dimension, social dimension, environment dimension, and self-assessment score in the traditional Chinese medicine group were higher than those in the control group (P<0.05). The scores of HAMA and SAS in the auricular acupuncture group were lower than those in the control group, and the scores of WHOQOL-BREF physiology dimension, social dimension, and environment dimension in the auricular acupuncture group were higher than those in the control group (P<0.05). There was no significant difference between the traditional Chinese medicine group and the auricular acupuncture group in the scale score after treatment. After treatment, the contents of IL-1β, IL-8, IL-10, IL-2, IFN-γ, and TNF-α in the traditional Chinese medicine group were lower than those before treatment (P<0.05), while there was no significant difference in the auricular acupuncture group before and after treatment. The total effective rate of HAMA in the traditional Chinese medicine group was 83.3%, in the auricular acupuncture group it was 76.7%, and in the control group it was 10.7%. There was a statistical difference among the three groups (P<0.05), while there was no statistical difference between the traditional Chinese medicine group and the auricular acupuncture group. Conclusion Traditional Chinese medicine therapy of soothing the liver and regulating the mind, including prescriptions and auricular acupuncture, can effectively relieve the anxiety of breast cancer patients, improve the quality of life, and is safe without side effects, so it has a certain clinical value. [ABSTRACT FROM AUTHOR]

Copyright of Sichuan Mental Health is the property of Sichuan Mental Health Center and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To explore the relationship between serum 25-hydroxyvitamin D [25 (OH) D], Vitamin B12 (VB12) and cognitive function and clinical efficacy in patients with generalized anxiety disorder (GAD) . Methods: 186 patients with GAD who were admitted to the Department of Psychology Clinic of the First Affiliated Hospital of Air Force Military Medical University from April2018 to June 2022 were selected as GAD group. Another 120 healthy volunteers who were underwent physical examinations in our hospital during the same period were selected as control group. The cognitive function in patients was evaluated and compared between two groups by the Wisconsin Card Sorting Test (WCST), and the serum 25 (OH) D and VB12 levels in patients were detected and compared between two groups. The correlation between serum 25 (OH) D, VB12 and cognitive function was analyzed by the pearson correlation. GAD group received routine treatment, they were divided into effective group and ineffective group based on the efficacy, and the changes in serum 25 (OH) D and VB12 levels were compared before and after treatment between effective group and ineffective group. Results: The serum 25 (OH) D and VB12 levels in GAD group were lower than those in control group (P＜0. 05) . The total number of completed categories, number of correct reactions, and total number of reactions in the control group were higher than those in the GAD group, while the number of incorrect responses and the number of persistent errors were lower than those in the GAD group (P＜0. 05) . Pearson correlation analysis showed that serum levels of 25 (OH) D and VB12 were positively correlated with t The total number of completed categories, number of correct reactions, and total number of reactions; There was a negative correlation with the number of incorrect responses and the number of persistent errors (P＜0. 05) . Among 186 patients, 36 cases were cured, 53 cases were significantly effective, and 62 cases were effective, and 35 cases were ineffective. Patients were divided into effective group (n=151) and ineffective group (n=35) according to the treatment situation. The serum 25 (OH) D and VB12 levels increased in two groups after treatment, and effective group were higher than those in control group (P＜0. 05) . Conclusion: The 25 (OH) D and VB12 levels in patients with GAD decrease, and which is related to the decline in cognitive function, patients with GAD with lower 25 (OH) D and VB12 levels also have poorer treatment outcomes, which is suggested that close attention should be paid to the 25 (OH) D and VB12 levels in patients during clinical diagnosis and treatment to develop corresponding treatment measures. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the efficacy of modified Naikan therapy combined with duloxetine for generalized anxiety disorder (GAD). Methods: A total of 79 patients with GAD were collected according to the criteria of the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10). They were randomly divided into modified Naikan therapy combined with duloxetine group (n=39) and the medication group received only duloxetine (n=39), two groups both received therapy for 4 weeks, and 5 cases of shedding in the Naikan combination group and 7 cases of shedding in the medication group. The Generalized Anxiety Disorder Scale (GAD-7), Penn State Worry Questionnaire (PSWQ), and the Perceived Social Support Scale (PSSS) were used for efficacy evaluation. Results: After 4 weeks of treatment, the scores of GAD-7 and PSWQ were lower than the baseline in both groups (Ps ＜0. 05), and the PSSS scores were higher than the baseline in the Naikan combined with the medication group (P ＜0. 05). The differences in the scores of all scales between the baseline and 4-week treatment were higher in the Naikan combined with the medication group than in the medication group (Ps ＜0. 05). Conclusion: Modified Naikan therapy combined with duloxetine is more effective than duloxetine treatment alone in patients with GAD, in which anxiety and worry could be effectively relieved. [ABSTRACT FROM AUTHOR]

Background Generalized anxiety disorder is a common chronic psychiatric disorder, which leads to cognitive impairment and seriously affects the quality of life and social function of patients. Objective To compare the differences in cognitive function between GAD inpatients and healthy controls. Methods From August 2018 to January 2020, GAD patients hospitalized in Nanfang Hospital, Southern Medical University were selected as the GAD group (n=30) . At the same time, age- and gender-matched healthy volunteers were recruited from the escorts of inpatients in Nanfang Hospital, Southern Medical University as the healthy control group (n=30) . The Hamilton Anxiety Scale (HAMA) , Hamilton Depression Scale (HAMD) and Beck scale for suicide ideation-Chinese Version (BSI-CV) were used for psychological evaluation. Psychomotor vigilance task (PVT) , Go/No-go association task and N-back task were used to evaluate the cognitive function of attention, inhibition and working memory separately. The differences in general conditions, psychological characteristics, and cognitive function between two groups were compared. Multivariate Logistic regression analysis was further used to compare the differences in cognitive function between GAD inpatients and healthy controls. Results The total scores of HAMA and HAMD, the total scores of BSI-CV at the most severe condition and the proportion of the patients with suicidal ideation at the most severe condition in GAD group were higher than those in control group (P

Objective To analyze the mediating effect of psychological resilience on anxiety and insomnia among medical staff in the fever clinic and to provide a theoretical basis for improving their symptoms of insomnia. Methods From January to July 2022, a general data questionnaire, a 7-item Generalized Anxiety Disorder Scale (GAD-7), a simplified version of the 10-item Connor-Davidson Resilience Scale (CD-RISC-10), and an Insomnia Severity Index (ISI) were used to survey medical staff in the fever clinic of a tertiary hospital in Tianjin. Descriptive statistics and correlation analysis were performed using SPSS 22.0 software; structural equation modeling was constructed using AMOS 25.0; and the mediating effect of psychological resilience on anxiety and insomnia was tested using the Bootstrap method. Results A total of 251 questionnaires were returned, of which 245 were valid, with a valid response rate of 97.6%;40.0% (98/245) of medical staff had symptoms of anxiety, and 39.1% (96/245) had symptoms of insomnia. The longer the working time and the higher the professional title, the higher the level of anxiety among medical staff (P < 0.05). Anxiety was positively correlated with insomnia (r = 0.276, P < 0.01), anxiety was negatively correlated with psychological resilience (r = - 0.388, P < 0.01), and psychological resilience was negatively correlated with insomnia (r = - 0.290, P < 0.01). Psychological resilience had a mediating effect between anxiety and insomnia, with a mediating effect of 0.074, accounting for 33.3% of the total effect. Conclusions The phenomenon of anxiety and insomnia among medical staff in fever clinics should not be ignored. Department managers should pay attention to the mental health status of these medical staff, take targeted measures to improve their psychological resilience level, improve their sleep quality, and ensure that fever clinic medical staff maintain a good mental state. [ABSTRACT FROM AUTHOR]

Objective: To investigate the changes of miRNAs expression in hippocampus of mice with human-derived fecal microbiota transplantation induced generalized anxiety disorder model and the regulatory effect of WenDan Decoction on miRNAs. The experimental groups underwent 14 days of antibiotic elution and 5 fecal microbiota transplants over 14 days, followed by WenDan Decoction for the last 7 days. At the end of the experiment, anxiety-like changes were detected by open field test and elevated plus maze test. The expression levels of miRNAs in the hippocampus of the experimental mice were analyzed by high-throughput sequencing. The key miRNAs were obtained by a combination of enrichment and network analysis methods and validated by RT-PCR. In the open field test, the total distance (P<0.05), time of central zone (P<0.01), and number of zone (P<0.05) were significantly lower in the anxiety model group compared to the control model group. Except for the total distance, the rest were significantly higher after treatment with WenDan Decoction (P<0.05). In the elevated plus maze test, the percentage of entries to the open arms (P<0.05) and the percentage of time spent in the open arms (P<0.01) were significantly lower in the anxiety model compared to the control model group, and both were significantly higher after treatment with WenDan Decoction (P<0.01). High-throughput sequencing results showed that there were 12 overlapping and directionally consistent miRNAs in the experimental group, with 9 significantly different key miRNAs, and 353 target genes were obtained from the annotation. KEGG analysis showed that miRNAs may be involved in the regulation of MAPK signaling pathway, glutamatergic pathway, calcium signaling pathway, and mTOR signaling pathway. The results of GO analysis showed that miRNAs may be involved in the regulation of the positive regulation of DNA transcription, the regulation of presynaptic assembly, the propagation of neuronal action potentials and glutamatergic synapses. RT-PCR results showed that the therapeutic effect of WenDan Decoction may be achieved through the regulation of miRNAs such as miR-26a-1-3p. Dysbiosis of intestinal flora in anxious patients leads to abnormal expression of miRNAs such as miR-7a-5p, miR-3077-3p, miR-26a-1-3p and so on. The therapeutic effect of WenDan Decoction is achieved by regulating miRNAs such as miR-26a-1-3p. [ABSTRACT FROM AUTHOR]

Objective To evaluate clinical efficacy and safety of transcutaneous neuromuscular electrical stimulation（TNES） in the treatment of erectile dysfunction（ED） combined with premature ejaculation（PE） for obtaining the evidence for clinical application of TNES. Methods Based on the inclusion and exclusion criteria, 25 patients with ED complicated with PE, who received TNES treatment in andrology clinic from June 2021 to February 2022, were recruited as the subjects. Before and after TNES treatment, RigiScan penile hardness measurement of the patients under audiovisual sexual stimulation（AVSS） was carried out, and Erection Hardness Score（EHS）, International Index of Erectile Function-5（IIEF-5）, Intravaginal Ejaculation Latency Time（IELT）, Premature Ejaculation Diagnostic Tool（PEDT）, Patient Health Questionnaire（PHQ-9） and Generalized Anxiety Disorder Questionnaire（GAD-7） were comparatively analyzed. Results Two patients were lost during follow up. Other 23 patients, who received TNES treatment, all completed the questionnaire follow-up and RigiScan penile hardness measurement under AVSS before and after treatment. They had no adverse reactions such as pain, skin burn, electrode allergy, subcutaneous congestion and so on at the treatment site. Before and after treatment, there were significant differences in erection time, average and maximum hardness of penis tip and average and maximum hardness of penis root（P＜0.05）, but no significant differences in circumference of penis tip and root（P＞0.05）. There were significant differences in EHS and IIEF-5 scores（P＜0.05）. The total effective rate of IIEF-5 score was 78.26%. IELT and PEDT were significantly different（P＜0.05）. In terms of psychology, there were no significant differences in GAD-7 anxiety score and PHQ-9 depression score（P＞0.05）. Conclusion As a non-invasive, effective, safe and feasible new treatment method, TNES can improve the erectile function and ejaculation ability of Patients with ED complicated with PE, and provide a new idea for the treatment of patients with ED complicated with PE. [ABSTRACT FROM AUTHOR]

Objective: To investigate the changes of serum neuropeptide Y (NPY), 5-hydroxytryptophan (5-HT) and brain-derived neurotrophic factor (BDNF) in first-episode generalized anxiety disorder (GAD) of adolescents with different anxiety levels and their correlation with life stress, inflammatory factors and memory function. Methods: 147 adolescent first-episode GAD patients who were admitted to Chengdu mental health center from January 2019 to December 2021 were selected, and they were divided into mild anxiety group (5-9 scores, 50 cases), moderate anxiety group (10-14 scores, 65 cases) and severe anxiety group (15-21 scores, 32 cases) according to the Generalized Anxiety Scale (GAD-7). Serum levels of NPY, 5-HT, BDNF, C-reactive protein (CRP), interleukin (IL) -1αand IL-6 were detected. Students’ Life Stress Inventory (SLSI) and delayed matching test (DMS) were used to evaluate the life stress level and memory function. The levels of serum NPY, 5-HT, BDNF, CRP, IL-1α and IL-6 as well as SLSI and DMS were compared between groups, and the correlation between serum levels of serum NPY, 5-HT and BDNF and levels of serum CRP, IL-1α and IL-6 as well as SLSI and DMS were analyzed. Results: The levels of serum NPY, 5-HT and BDNF in severe anxiety group were lower than those in moderate anxiety group and mild anxiety group (P<0.05), and the moderate anxiety group was lower than the mild anxiety group (P<0.05). The levels of CRP, IL-1α and IL-6 and SLSI score in severe anxiety group were higher than those in moderate anxiety group and mild anxiety group (P<0.05). The moderate anxiety group was higher than the mild anxiety group (P<0.05). The total delayed response time and no delayed response time in the severe anxiety group were longer than those in the moderate anxiety group and the mild anxiety group (P<0.05), and the moderate anxiety group was longer than the mild anxiety group (P<0.05). The total delayed correct number and no delayed correct number in severe anxiety group were less than those in moderate anxiety group and mild anxiety group (P<0.05),and the moderate anxiety group was less than the mild anxiety group (P<0.05). The levels of serum NPY, 5-HT and BDNF were negatively correlated with SLSI score, CRP, IL-1α, IL-6, total delayed response time and no delayed response time (P<0.05), and positively correlated with total delayed correct number and no delayed correct number (P<0.05). Conclusion: With the aggravation of anxiety, life stress intensity, inflammatory factor level and memory function of adolescent first-episode GAD patients are enhanced, and all of them are related to the decrease of the levels of serum NPY, 5-HT and BDNF. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effects of cognitive coping therapy (CCT) combined with paroxetine on the short-term clinical efficacy, social function and cognitive function in patients with generalized anxiety disorder (GAD). Methods: A total of 70 patients with GAD were collected according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). They were divided into CCT combined with paroxetine group 35 cases (31 cases completed) and paroxetine group 35 cases (32 cases completed) according to the random number table. The two groups of patients completed the Self-rating Anxiety Scale (SAS), Hamilton Anxiety Scale (HAMA), and Social Disability Screening Schedule (SDSS) assessment, event-related potential P300 examination, and MATRICS Consensus Cognitive Battery (MCCB) test on the baseline and 4 weeks after treatment. Results: After 4 week treatment, the scores of SAS, HAMA, and SDSS were lower in the CCT combined with paroxetine group than in the paroxetine group (P <0.05). The scores of attention/vigilanye, reasoning and problem-solving ability, and social cognition areas in MCCB were higher in the CCT combined with paroxetine group than in the paroxetine group (P <0.05), and the total significant efficiency was significantly higher in the CCT combined with paroxetine group (51.6%) than in the paroxetine group (25%). Conclusion: Cognitive coping therapy combined with paroxetine therapy has a certain synergistic effect on the treatment of patients with GAD in which the social function and cognitive function can be effectively improved. [ABSTRACT FROM AUTHOR]

To explore the synergistic effect of combined mindfulness training on generalized anxiety disorder based on Modified Morita therapy. Methods: Totally 150 inpatients with generalized anxiety disorder were recruited and randomly divided into Modified Morita therapy combined with mindfulness training group ( combined group) and Modified Morita therapy control group ( single group), with 75 cases in each group. Finally, 65 cases in the combined group and 66 cases in the single group completed the study. Both groups received drug therapy and Modified Morita therapy, and the combined group received mindfulness training for 5 weeks. The Hamilton Anxiety Scale ( HAMA), Chinese version of Self-rating Scale for the TORAWARE state of Neurosis (SSTN) and Five Facts Mindfulness Questionnaire (FFMQ) were used to evaluate the treatment effects before and after the intervention. Results: After 5 weeks of intervention, the total scores of HAMA and SSTN were lower in the combined group than in the single group, while the total scores of FFMQ were higher in the combined group than in the single group (Ps

Objective: To assess the clinical efficacy of escitalopram combined with Chinese massage on generalized anxiety disorder. Methods: This randomized controlled clinical trial had a total of 184 patients with the generalized anxiety disorder who met the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV). The main complains were discomfort in neck, shoulder and back. The subjects were divided into two groups, namely escitalopram group ( n = 92) and escitalopram combined with Chinese massage group (n = 92). The status of anxiety and depression were assessed with the Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) before enrollment and 6 weeks after treatment, respectively. The HAMA score reduction rate ≥75% was considered as marked effective and the HAMA score reduction rate ≥50% was considered as effective after treatment. Results: The HAMA scores after treatment in two groups were both lower than those before treatment (P <0. 001), and the HAMA scores after treatment were lower in the escitalopram combined with Chinese massage group than in the escitalopram group (P < 0. 01) . In addition, there was a significant interaction between group and time ( P < 0. 00 l). The marked effective rate was higher in the escitalopram combined with Chinese massage group than in the escitalopram group (28. 2% vs. 13. 3%, P <0. 05) . Conclusion: The clinical efficacy of escitalopram combined with Chinese massage showed better efficacy in treatment of generalized anxiety disorder wi1h discomfort in neck, shoulder and back. [ABSTRACT FROM AUTHOR]

Objective: To study the changes and significance of mi RNA expression profile in the prefrontal cortex of mice with generalized anxiety disorder induced by chronic restraint stress (CRS).Methods: After 7 days of CRS, the mice were tested by open field experiment and elevated plus maze experiment to detect whether the mice can show nervous and anxious behaviors. High-throughput sequencing was used to quantitatively analyze the expression levels of mi RNAs in the prefrontal cortex of mice in the control and model groups, and to study the molecular expression profiles related to anxiety induced by CRS. The differentially expressed mi RNAs in the sequencing results were verified by RT-PCR. Results: In mice in the CRS-induced generalized anxiety disorder model group, the total distance of activities in the model group increased (P<0.05), the average speed (P<0.05) increased, the central residence decreased (P<0.05), and the percentage of open arm entry times (P<0.01) and residence time of the open arm (P<0.01)are reduced. Compared with the control group, the results were statistically significant, indicating that the GAD mice were successfully modeled. Based on the results of high-throughput sequencing and bio-informatics analysis, compared with the control group, there were 28 up-regulated mi RNAs and 34down-regulated mi RNAs in the model group and 5388 target genes participated in the changes. In the up/down-regulated mi R-GO analysis results, they are mainly involved in the development of the nervous system, postsynaptic density, neuron projection, protein serine/threonine kinase activity and other processes ;in the up/down-regulated mi R-KEGG results, they participate in common pathways Mainly include axon guidance, neurotrophic factor signaling pathway, cAMP signaling pathway, dopaminergic synapse, MAPK signaling pathway and so on. Conclusion: The changes of mi R-7a-5p, mi R-124-3p, mi R-141-3p, mi R-183-5p and other mi RNAs in the prefrontal cortex are involved in the pathogenesis of generalized anxiety disorder, and may regulate and affect nerve conduction functions. [ABSTRACT FROM AUTHOR]

Objective: To observe the effects of low frequency repetitive transcranial magnetic stimulation (rTMS) combined with escitalopram on quality of life and event-related potential P300 in patients with generalized anxiety disorder (GAD). Methods: Using random number table method, 120 patients with GAD who were admitted to our hospital from February 2019 to January 2021 were divided into control group (escitalopram treatment) and study group (low frequency rTMS treatment based on the control group), 60 cases in each group. The efficacy and adverse reactions of the two groups were observed and compared, and the changes of quality of life and event-related potential P300 were recorded. Results: The total clinical effective rate of the study group was higher than that of the control group (P<0.05). 2 months after treatment,the incubation period of P300 of the study group was shorter than that of the control group, and the amplitude of P300 was longer than that of the control group (P<0.05). The scores of pain, physical function, mental health, physical function, physical energy, emotional function, social function and overall health of the study group were higher than those of the control group at 2 months after treatment (P<0.05). 2 months after treatment, the scores of Hamilton Anxiety Scale (HAMA) in both groups were lower than those before treatment, an the study group was lower than the control group (P<0.05). There was no statistical difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Low frequency rTMS combined with escitalopram can effectively improve the anxiety symptoms of patients with GAD,improve the quality of life, promote the recovery of cognitive function, and which has significant clinical efficacy. [ABSTRACT FROM AUTHOR]

Objective: To explore the correlation between personality characteristics and immune function, thyroid hormone and neuroendocrine hormone in patients with generalized anxiety disorder (GAD). Methods: 80 patients with GAD who were treated in Department of Psychology, Northern Theater Air Force Hospital from January 2019 to December 2020 were selected as the study group, and 80 healthy volunteers who underwent physical examination of the Northern Theater Air Force Hospital in the same period served as the control group. The simple Eysenck Personality Questionnaire (EPQ-RSC) was used to evaluate the personality characteristics of the subjects. The results of EPQ-RSC score, the proportions of CD3+, CD4+ and natural killer (NK) cells in blood, serum interleukin (IL)-2 andIL-6, triiodothyronine (T3), thyroxine (T4), free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), norepinephrine (NE), adrenocorticotropin (ACTH) and cortisol (CS) levels were compared between the two groups, and their correlation were analyzed. Results: The psychoticism(P), neuroticism(N) and EPQ-RSC total scores in the study group were significantly higher than those in the control group (P<0.05), CD3+, CD4+ and NK in the study group were significantly lower than those in the control group, and IL-2and IL-6 were significantly higher than those in the control group (P<0.05). FT3 and FT4 in the study group were significantly lower than those in the control group(P<0.05). CS in the study group was significantly lower than that in the control group, NE and ACTH were significantly higher than those in the control group (P<0.05). Pearson correlation analysis showed that N, P and EPQ-RSC total scores were negatively correlated with CD3+, CD4+, NK, FT3, FT4 and CS of GAD(P<0.05), and positively correlated with IL-2, IL-6, NE and ACTH(P<0.05). Conclusion: Patients with GAD have impaired immune function and abnormal levels of neuroendocrine hormone and thyroid hormone, which are related to P and N propensity personality characteristics of patients. [ABSTRACT FROM AUTHOR]

This study aims to explore the mechanism of Dabugan Decoction in the treatment of generalized anxiety disorder(GAD) based on network pharmacology, molecular docking, and animal experiments. Network pharmacology and molecular docking technology were used to obtain the possible targets and related signaling pathways of Dabugan Decoction in the treatment of GAD. The GAD rat model was established, and the corresponding drugs were given by gavage after randomization. After 28 days of continuous intervention, the anxiety state of rats was detected, and the pathological changes of the hippocampus were detected in each group. ELISA and Western blot were used to detect the protein expression levels of related molecules. A total of 65 drug compounds in Dabugan Decoction were obtained, involving 403 targets of action, 7 398 disease targets of GAD, and 279 common targets of &quot;drug-disease&quot;. The key nodes in the protein-protein interaction(PPI) network were Akt1, TNF, IL-6, TP53, IL-1β, etc. Function analysis of Gene Ontology(GO) and enrichment analysis of Kyoto Encyclopedia of Genes and Genomes(KEGG) showed that the PI3K-Akt signaling pathway was the most important pathway. The results of molecular docking showed that the core components of the drug had good binding activity with the corresponding key targets. Animal experiments showed that Dabugan Decoction could effectively improve the anxiety behavior of rats and increase the open arm end movement distance and total distance of rats in the elevated cross labyrinth, the number and stay time of entering the open box, and the time(%) and the number of entering the center of the open field. At the same time, HE staining and Nicil staining showed that the number of hippocampal nerve cells in rats increased, and they were closely arranged. The damage to the cell body was improved, and there was an increase in Nissl substances in the cells. The expression of TNF-α, IL-6, and IL-1β in rat hippocampus decreased, and the expression of TP53, p-Akt1, and p-PI3K increased. The mechanism may be related to the activation of the PI3K-Akt signaling pathway and the inhibition of inflammatory response. Dabugan Decoction can play a good therapeutic and regulatory role in GAD, reflecting the overall effect of traditional Chinese medicine(TCM) compound and the characteristics of multiple targets and multiple pathways. At the same time, it is preliminarily discussed that the state of GAD may be improved by Dabugan Decoction via-activating PI3K-Akt signaling pathway and inhibiting inflammatory response and anti-apoptosis, thus providing experimental data support for the clinical application of Dabugan Decoction.

Objecctive: To observe the clinical curative effect of Sun's abdominal-acupuncture on generalized anxiety disorder (GAD). Method: Sixty patients meeting the inclusion criteria were randomly divided into two groups. The experimental group was treated with abdominal area-1 and abdominal area-8 of Sun's abdominal-acupuncture, and conventional acupuncture. The control group was treated with conventional acupuncture. The score was recorded before the treatment, after one week's treatment, after two weeks' treatment, after three weeks' treatment for the evaluation of the therapeutic effect. Results: Hamilton reductive ratio was taken to measure the results of this methods. Hamilton reductive ratio evaluates the results: the total effective rate of experimental group after three weeks treatment was 93.33 %, the rate of control group after three weeks treatment was 80.00 %. Statistical analysis showed that there was a significant difference between the two groups (P＜0.05). Conclusion: Treatment by abdominal area-1 and abdominal area-8 of Sun's abdominal- acupuncture of generalized anxiety disorder with liver-qi stagnation syndrome is more effective than conventional acupuncture alone, and the patient's condition has improved significantly; treatment by Sun's abdominal-acupuncture can significantly improve mental anxiety and has more advantages than conventional acupuncture alone. [ABSTRACT FROM AUTHOR]

Attention bias modification (ABM) can correct the attention bias of patients with generalized anxiety disorder (GAD) and improve their symptoms. However, the therapeutic mechanism of ABM is poorly understood (Macleod & Clarke, 2015). In this study, 28 patients (18 women and 10 men; average age = 46.04 years) with GAD were recruited. In addition, 28 healthy people (22 women and 6 men; average age = 45.43 years) were recruited as the control group. All participants were randomly assigned to either the ABM group (receiving neutral stimuli for attention training) or the placebo-training group (receiving no specific stimuli). Before and after training, both groups received two types of attention network test (ANT)-the standard ANT and the emotion ANT (e-ANT)-to assess changes in the alerting network, the orienting network, and the executive control network of the participants; e-ANT, in which threatening and neutral words serve as clues, is used to assess alertness to neutral or threatening stimuli as well as orientations, from neutral to threatening and from threatening to neutral stimuli. The results indicated that the attention allocation of the patients with GAD was inflexible. Compared with the control group, the patients’ conflict-monitoring abilities were unsatisfactory. Moreover, the patients were significantly highly alert to symbols, neutral stimuli, and threatening stimuli. Compared with the control group, shifting attention from threatening stimuli to neutral stimuli was more difficult for patients with GAD. After receiving training (of any type), the ability of patients with GAD to shift their attention from threatening stimuli to neutral stimuli improved significantly, possibly because the participants responded strategically during attention training. These results clarify the processes underlying attention bias in patients with GAD as well as the relationship between such processes and ABM, from the perspectives of the alerting, orienting, and executive control networks proposed by Posner. [ABSTRACT FROM AUTHOR]

Objective · To investigate the level of intolerance of uncertainty (IU) and possible related factors in the patients with anxiety disorders. Methods · The patients' diagnosis was made according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM- Ⅳ ). Thirty-five cases of generalized anxiety disorder (GAD), 15 cases of panic disorder (PD) and 31 healthy controls (HC group) were recruited at the same time. IU level was assessedusing the Chinese version of Intolerance of Uncertainty Scale (IUS). The characteristics of anxiety symptoms, depressive symptoms and body perception were assessedHamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD) and Body Perception Questionaire (BPQ), respectively. Results · The IU levels of both GAD group and PD group were significantly higher than those of HC group (P0.000). There was no significant difference in IU levels between GAD group and PD group (P0.491). The IU levels of GAD patients were positively correlated with HAMA-somatic anxiety (r0.377, P0.025) and BPQ-awareness (r0.342, P0.044). Conclusion · The patients with anxiety disorders have elevated IU levels, compared with healthy people. Possibly, somatic anxiety and body perception-awareness are related factors to IU in GAD patients. [ABSTRACT FROM AUTHOR]

Objective: To explore the effect of group reality therapy for the patients with mild to moderate generalized anxiety disorder (GAD). Methods: One hundred and nineteen patients with mild to moderate GAD were randomly divided to the group reality therapy research group (n =60. the research group) and the non-group reality therapy control group (n =59, the control group), and there were one hundred and fourteen patients finished the whole study (58 patients in the research group and 56 patients in the control group). The research group attended group reality therapy for 8 weeks (once a week, and 2 hours every time), and the control group attended the lecture on mental health altogether every week. All the participants were measured at baseline and 8 weeks later respectively with the Hamilton anxiety Scale (HAMA), Hamilton depression Scale (HAMD), and various indexes of heart rate variability (HRV). Results: The scores of HAMA, psychiatric anxiety, somatic anxiety and HAMD were lower in the research group than in the control group 8 weeks later (Ps<0.01). The comparison within groups showed that the scores of HAMA, psychiatric anxiety, somatic anxiety and HAMD in the research group 8 weeks later were lower than that at baseline (P<0.001). The comparison of the difference of standard deviation of NN intervals (SDNN), root mean square of successive RR interval differences (RMMSD), percentage of successive RR intervals that differ by more than 50 ms (PNN50), high frequency (HF) between baseline and 8 weeks later were lower than that in the control group, the comparison of the difference of low frequency (LF), very-low frequency (VLF), LF/HF between baseline and 8 weeks later were higher than that in the control group (Ps<0.05). Conclusion: Group reality therapy may be effective for the treatment of anxiety and depression symptoms in patients with mild to moderate GAD, and it could also increase the vagal activity and decrease the sympathetic activity. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the efficiency of 24-week combination therapy of selective serotonin re-up-take inhibitors (SSRIs) and cognitive behavioral therapy (CBT) for patients with generalized anxiety disorder (GAD). Methods: Forty eight GAD patients who met the definition and criteria of the International Statistical Classification of Diseases and Health Related Problems, Tenth Revision (ICD-10) were recruited from a tertiary psychiatric hospital. All patients were randomly divided into the SSRIs and CBT treatment group and the SSRIs control group. The Hamilton Anxiety Rating Scale (HAMA) was administered to evaluate efficiency of the therapies. The Generalized Estimated Equation (GEE) was used to test differences of clinical effect of treatment. Results: There were 24 patients in the treatment group and 24 patients in the control group. Totally 19 patients dropped out from the trial, and the drop-out rate was 39. 6%. Controlled by gender, age, disease period, baseline scores of HAMA, the treatment group had better clinical effect than that of control group (P<0.001). OR of the treatment group, the odds ratio of progressing to the next better rank compared with control group, was 21.83 (95% CI. 5.92 -80. 41). There was no association between intolerance and the clinical effect in the treatment group, and it reached the highest drop-out rate when CBT was provided every six weeks. For the control group, those patients who finished the whole trial had better clinical effect than those who withdrew the trial (P<0.05), and OR was 5.82 (95% CI: 1.44-23.63). Conclusion: This randomized control trial indicates that the combination therapy of SSRIs and CBT is more effective than SSRIs treatment for GAD. The intolerance of patients in SSRIs treatment group was related to unsatisfied clinical effect, while it was due to the long CBT treatment intervals for patients who received the combination therapy of SSRIs and CBT. [ABSTRACT FROM AUTHOR]

Objective: To survey the status of anxiety/depression and lifestyle among junior high school students and explore their relation to put preference for psychological health education. Methods: Totally 1597 jun­ior high school students aged 10 to 17 years in Shang Haicity were surveyed. The Generalized Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire-9 items (PHQ-9) and Chinese Adolescent Lifestyle Scale (CALS), were used to assess anxious emotion, depressive emotion and lifestyle. Results: The rates of anxious emotion and depres­sive emotion were 16. 4% and 17. 2% respectively among students. Scores of GAD-7 and PHQ-9 were negatively correlated with all factor scores of CALS including eating habits, sleep status, health habits, learning habits , exer­cise, entertainment activities, interpersonal relationships, coping style and life satisfaction ( -0.57⩽r⩽ -0.15, Ps < 0. 01). Multivariate stepwise regression analysis showed that the sleep status factor scores, life satisfaction and ex­ercise factor scores of CALS could negatively predict scores of GAD-7 (β = -0. 17, -0. 15, -0. 05; Ps <0. 05) and health habits positively predict scores of GAD-7 (β = 0. 08, P < 0. 001). Sleep status factor scores, life satisfac­tion factor scores and eating habits factor scores could negatively predict scores of PHQ-9 (β = -0. 21, -0. 16,- 0. 06; Ps <0. 05). Conclusion: It suggests that the junior high school students" depression and anxiety are related to their lifestyle. The emotion of depression and anxiety of students may be predicted by some factors in the lifestyle. [ABSTRACT FROM AUTHOR]

Objective: To explore the efficacy of group cognitive-behavioral therapy (GCBT) to generalized anxiety disorder (GAD). Methods: In this randomized controlled trial, the control group (n, =23) and the intervention group (n, =33) were included, all of the participants received duloxetine (30 - 120 mg/d) as pharmacotherapy. The intervention group received 8 group cognitive-behavioral therapy sessions weekly, 90 minutes for each time. Assessments were conducted with the Hamilton Anxiety Scale ( HAMA), Hamilton Depression Scale (HMAD) and Clinical Global Impression (CGI) at baseline, mid-treatmentand post-treatment. CGI included three factors, the severity of illness (SI), the globalimprovement (GI) and the efficacy index (EI). Results: The repeated measures analysis of variance of HAMA showed that, there were statistical significance on the HAMA for interaction between measure time and group processing (F = 4. 35, P <0. 05). Compared with the control group, the intervention group got higher decreased scores of HAMA at the 4th week and 8 th week, and higher prevalence of being cured and efficient at the 4th week. At the 8 th week, the decreased scores of HMAD were higher in the intervention group than in the control group, and the scores of CGI-SI and the CGI-IE were lower in the intervention group. Conclusion: It suggests that group cognitive-behavioral therapy combined with pharmacotherapy could be earlier to be effective, and the symptoms of anxiety, depression and the state of illness could be improved more significantly compared with pharmacotherapy alone. [ABSTRACT FROM AUTHOR]

Objective: To observe the therapeutic effect of acupuncture combined with cranial electrotherapy stimulation (CES) on generalized anxiety disorder (GAD)., Methods: A total of 200 patients with GAD were randomized into an acupuncture+CES group, an acupuncture group, a CES group and a medication group, 50 cases in each one. In the medication group, patients were treated with tandospirone citrate tablet orally, 10 mg after breakfast, lunch and dinner respectively. In the CES group, CES was adopted by SCS brain electromedical instrument, 60 min each time, once a day. In the acupuncture group, acupuncture was applied to Baihui (GV 20), Sishencong (EX-HN 1), Yintang (GV 29), Shenting (GV 24), etc., 30 min each time, once a day. In the acupuncture+CES group, CES was adopted before acupuncture. Treatment of sixty days was required in the 4 groups. Before and after treatment, the scores of Hamilton anxiety scale (HAMA), World Health Organization's quality of life questionnaire-brief version (WHOQOL-BREF) and treatment emergent symptom scale (TESS) were observed, the clinical effect was evaluated, and the relapse of anxiety during follow-up of 1 year after treatment was recorded in the 4 groups., Results: Compared before treatment, the scores of HAMA after treatment were decreased ( P <0.05), the scores of WHOQOL- BREF after treatment were increased in the 4 groups ( P <0.05), and the improvements of above scores in the acupuncture+CES group were greater than the other 3 groups ( P <0.05). The score of TESS after treatment and the relapse rate of 1-year follow-up in the medication group were higher than those in the other 3 groups ( P <0.05). The total effective rate in the acupuncture+CES group were superior to the other 3 groups ( P <0.05)., Conclusion: Acupuncture combined with CES can effectively relieve the symptoms in patients with GAD, improve the quality of life, reduce the occurrence of adverse reactions and the relapse rate, and its clinical effect is obviously superior to the western medication, the simple application of acupuncture or CES.

This study was aimed to observe the clinical efficacy of anxiolytic compound prescription with Valerianae Jatamansi Rhizoma et Radix (ACPV) in treating liver Qi stagnation and feel ill at ease type generalized anxiety disorder (GAD). Sixty-seven patients diagnosed as GAD with stagnation of liver Qi and feel ill at ease were randomly divided into treatment group and control group. Patients in treatment group (n=34) was treated with ACPV decoction, and patients in control group (n=33) were treated with deanxit. Both groups were treated with respective drugs for 4 weeks. HAMA scale, traditional Chinese medicine (TCM) symptom scale (liver Qi stagnation and feel ill at ease type) and salivary cortisol levels were measured before and 2 weeks and 4 weeks after drug treatment. The life events scale (LES) and drug safety evaluation were performed before and after 4 weeks treatment. Two patients were excluded according to LES, and 5 patients were discontinued. Sixty patients were enrolled in the study finally (30 cases in each group). As compared with baseline, HAMA scores in both groups were significantly decreased at 2 weeks and 4 weeks (P<0.05, P<0.01). After 2 weeks and 4 weeks treatment, the TCM syndrome score in both group was also significantly improved (P<0.01). Moreover, the salivary cortisol levels in both groups were also decreased at 2 weeks and 4 weeks (P<0.05, P<0.01). The total efficiency between two groups had no statistically significant difference after 2 weeks treatment and 4 weeks treatment; moreover, no statistically significant differences were observed between two groups in HAMA scores, TCM syndrome scale scores and salivary cortisol levels between two groups. The incidence of adverse reactions in the treatment group was significantly lower than that in the control group (P<0.01), and there were no obvious side effects in general physical examination during the period of treatment. Thus, anxiolytic compound prescription with Valerianae Jatamansi Rhizoma et Radix is effective for GAD (stagnation of liver Qi and feel ill at ease type)., Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose., (Copyright© by the Chinese Pharmaceutical Association.)