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Objective To explore autologous skull cryopreservation protocol, including storage temperature, storage time, storage method, and management process. Methods The clinical data of 325 patients who underwent decompressive craniectomy and autogenous skull transplantation in the Department of Neurosurgery, General Hospital of Ningxia Medical University from January 2016 to December 2021 were analyzed retrospectively. The relevant literature were reviewed. According to the exploratory preservation plan, the data from 2016 to 2018 were divided into the old management group and the data from 2019 to 2021 were divided into the new management group. The evaluation study on the effect of autologous skull transplantation was conducted for both groups of data. Results The average cryopreservation time of autogenous skull was 122.9 days. The average hospital stay after replantation was 12.3 days. After the application of the new preservation scheme and management process, the intracranial infection rate decreased from 3.4% to 1.7%. Conclusions Cryopreservation of autologous skull at 80 °C is effective and can reduce the incidence of intracranial infection. [ABSTRACT FROM AUTHOR]

Objective: To investigate the risk factors of intracranial infection caused by craniotomy and the clinical therapeutic effect. Methods: The case data of 661 patients who underwent craniotomy in our hospital from January 2018 to December 2022 were retrospectively selected. Clinical data of patients undergoing craniotomy were collected to determine the occurrence of intracranial infection caused by craniotomy. The risk factors of intracranial infection after craniotomy were determined by univariate and binary Logistic retrospective analysis. To analyze the distribution and composition of pathogenic bacteria in intracranial infected patients and the therapeutic effect of intracranial infected patients after craniotomy. Results: The incidence of postoperative intracranial infection was 5.75% in 661 patients with craniotomy. Among 38 patients with intracranial infection after craniotomy, there were 30 cases of gram-positive bacteria, accounting for 81.58% (31/38), 8 cases of gram-negative bacteria, accounting for 18.42%(7/38), and staphylococcus, accounting for 78.95%(30/38), accounted for the largest proportion. The protective factors were preoperative prophylactic antibiotics, and the risk factors were operative time 4 h, albumin level 36 g/L, postoperative cerebrospinal fluid leakage, indwelling drainage tube, and infratentorial surgery(P<0.05). Among the 38 patients, 33 were cured and 5 had no clinical symptoms at discharge. All patients were followed up by outpatient or telephone for 3-6 months after discharge, and there was no recurrence of inflammation. Conclusion: After craniotomy postoperative incidence of intracranial infection is 5.75%, protective factors for preoperative prophylactic antibiotics, risk factors for operation time 4 h, albumin level 36 g/L, postoperative cerebrospinal fluid leakage, indwelling drainage tube, screen operation, craniotomy postoperative intracranial infection accounted for the most, by giving active treatment, for confirmed craniotomy postoperative intracranial patients infection, early diagnosis and give sufficient amount of sensitive antibiotics treatment. [ABSTRACT FROM AUTHOR]

Objective To analyze the status of the bacteria in the operative area of transnasal skull base surgery and its correlation with postoperative intracranial infection. Methods The procedure of transnasal skull base surgery was divided into three stages: nasal passage preparation(stage 1), tumor resection(stage 2), and skull base reconstruction(stage 3). Bacterial sampling was taken from the mucosa of the anterior wall of sphenoid sinus or clival recess of sellar floor at the beginning of each stage; and the positive rate of bacterial culture in different stages of operation and its correlation with postoperative intracranial infection were analyzed. Results A total of 105 patients were enrolled in this study, and 315 samples were taken. The average time point of sampling in the three stages was 20.3, 45.1 and 131.3 min after the beginning of operation, respectively. The positive results were 9 cases(2.9%)in the stage 1, 8 cases(2.5%)in the stage 2, and 23 cases(7.3%)in the stage 3, which were 24 cases of Staphylococcus epidermidis, 7 cases of Staphylococcus aureus, 3 cases of hemolytic streptococcus, 2 cases of Klebsiella pneumonia, and 4 cases of Escherichia coli. There was no significant difference in the positive cases between stage 1 and stage 2(P=0.955), but there were significant differences between stage 1 or 2 and stage 3(P=0.013; P=0.007). There were 36(11.4%)patients with at least one positive result in the three stages, 17(16.2%)with cerebrospinal fluid leakage, and 12(11.4%)with intracranial infection. The risk of intracranial infection was 3.1 times higher in patients with positive bacterial culture than patients with negative bacterial culture(OR=3.1, 95% CI :0.9-10.6), which was not statistically significant; patients with CSF leakage were 61.4 times higher than those without CSF leakage(OR=61.4, 95% CI:11.2-337.1), which was statistically significant(P<0.001). The consistency rate of bacteria in nasal cavity and postoperative cerebrospinal fluid culture was 57.1%. Conclusion The positive rate of bacterial culture in the operative area of transnasal skull base surgery increases significantly with the extension of operation time, which is a potential risk index of postoperative intracranial infection. [ABSTRACT FROM AUTHOR]

Objective: To explore the risk factors of intracranial infection in neurosurgery patients after craniocerebral surgery, and to study the clinical efficacy of traditional Chinese medicine surgery "Tufa" as an auxiliary treatment for intracranial infection. Methods:Retrospectively analyze the clinical data of 260 patients who underwent craniocerebral surgery in neurosurgery of our hospital from January 2017 to December 2022, and analyze the influencing factors of postoperative intracranial infection. Patients with postoperative intracranial infection were treated with traditional Chinese medicine "Tuofe" on the basis of conventional anti infection treatment, and their clinical therapeutic efficacy, cerebrospinal fluid leukocyte count, protein content and neutrophils, as well as serum interleukin-8 (IL-8), hypersensitive C-reactive protein (hs CRP) and Calcitonin (PCT) after anti infection treatment were analyzed. Results: Among 260patients undergoing neurosurgery craniocerebral surgery, 21 patients had intracranial infection after surgery, and the incidence of postoperative intracranial infection was 8. 08%. Multivariate logistic regression analysis showed that operation time, cerebrospinal fluid shunt, external ventricular drainage and cerebrospinal fluid leakage were independent factors influencing whether intracranial infection occurred after neurosurgery craniocerebral surgery. After using the traditional Chinese medicine surgical "support method" to assist in anti infection treatment, the cerebrospinal fluid white blood cell count, protein content, and neutrophils of 21 patients with postoperative intracranial infection were significantly reduced compared to before treatment (P＜0. 05), and serum IL-8, hs CRP, and PCT were all reduced compared to before treatment (P＜0. 05) . The total effective rate, anti infection treatment time, and total cost of 21 postoperative intracranial infection patients were 90. 48% (11. 43 ±1. 57) days, and (7571. 68 ±2541. 29) yuan, respectively. Conclusion: Operation time, cerebrospinal fluid shunt, external ventricular drainage and cerebrospinal fluid leakage are independent influencing factors that affect whether intracranial infection occurs after craniocerebral surgery in neurosurgery patients. Traditional Chinese medicine surgery "support therapy" helps to improve the anti infection treatment effect of patients with intracranial infection after surgery. [ABSTRACT FROM AUTHOR]

Objective This study aims to establish a nomogram model for predicting the risk of postoperative intracranial infection in patients with severe neurological diseases. Methods A retrospective study was conducted on clinical data from 200 patients who underwent surgical treatment in our hospital’s neurosurgical care unit between January 2018 and January 2021. The patients were randomly divided into a training set(n=140)and a validation set(n=60). Univariate analysis and multivariate logistic regression analysis were used to screen the risk factors，constructing the prediction model by nomogram. The receiver operating characteristic (ROC) curve was plotted to assess the predictive efficacy of the nomogram model for intracranial infection in patients with severe neurological diseases. Additionally，validation of the model and evaluation of its clinical net benefit were performed using decision curve analysis(DCA). Results The protopathy，external ventricular drainage time and lumbar cisterna drainage time were the risk factors for postoperative intracranial infection(P < 0.05). ROC curve of the nomogram model showed that the area under curve(AUC) of the training set and the validation set were 0.774(95% CI 0.695~0.853)and 0.831(95% CI 0.725~0.936)，respectively. DCA curves showed that the prediction of intracranial infection could improve the clinical benefit rate. Conclusion: Our nomogram prediction model based on risk factors associated with postoperative intracranial infection in patients with severe neurological diseases offers an effective approach for early identification of high⁃risk individuals facilitating prompt diagnosis and treatment while improving the prognosis of patients. [ABSTRACT FROM AUTHOR]

To establish and verify the prediction model of intracranial infection after minimally invasive puncture drainage for hypertensive intracerebral hemorrhage (HICH) based on clinical data. Methods A total of 231 patients with HICH treated by minimally invasive puncture drainage were included. According to postoperative intracranial infection occurrence, patients were divided into infected group and non-infected group. 16 factors that may be associated with intracranial infection after puncture and drainage of HICH were analyzed and compared. The least absolute shrinkage and selection operator (LASSO) regression was used to practice features selection and discover predictors. The multivariate logistic regression was used to establish the prediction model and constructe nomogram. Receiver operating characteristic (ROC) curve and calibration curve were respectively used to detect the discrimination and degree of fitting of the model. Decision curve analysis (DCA) was used to evaluate the clinical applicability of the prediction model. Results Four predictors (double drainage tubes, cerebrospinal fluid leakage, drainage duration, and urokinase injection times) were screened by LASSO regression, which were incorporated into logistic regression and mapped. It has been verified that the area under the curve of ROC was 0.779. The calibration curve showed that the predicted probability was in good agreement with the actual probability. DCA showed the clinical applicability of the model in a certain range. Conclusion The prediction model of intracranial infection after minimally invasive puncture for HICH established in this study has good differentiation, degree of fitting and clinical applicability, which is conducive to the early identification and targeted treatment of high-risk patients with postoperative intracerebral infection [ABSTRACT FROM AUTHOR]

Objective: To explore the phase-contrast magnetic resonance image (PC-MRI) technology analysis the changes of cerebrospinal fluid hydrodynamics before and after surgery in patients with subtonsillar hernia (Chiari) malformation type I and the influencing factors of postoperative intracranial infection. Methods: In this study, 80 patients with Chiari malformation type I who were admitted to our hospital from January 2019 to January 2022 were selected for study. MRI and PC-MRI examinations were performed on the head and neck of all patients, and cerebrospinal fluid hydrodynamics were analyzed using Q-flow software. The cerebrospinal fluid hydrodynamics indexes of patients with Chiari malformation type I were compared before and after surgery. The difference of clinical features between postoperative intracranial infection and non-intracranial infection in patients with Chiari malformation type Ⅰ were analyzed. Multivariate Logistic regression analysis of the influencing factors of postoperative intracranial infection in patients with Chiari malformation type I. Results: 3 months after surgery, the mean flux (MF), stroke volume (SV) and regurgitant fraction (RF) in the patients with Chiari malformation type I were significantly higher than those at 24 h before surgery, and the maximum peak velocity of foot (Vdmax) and maximum peak velocity of head (Vumax) were significantly lower than those at 24 h before surgery(P<0.05). 3 months after surgery, the ventral pons MF and SV in the patients with Chiari malformation type I were significantly higher than those at 24 h before surgery, and RF, Vdmax and Vumax were significantly lower than those at 24 h before surgery (P<0.05). 3 months after surgery, ventral MF and SV of C3 and RF, Vdmax and Vumax in the patients with Chiari malformation type I were significantly higher than those at 24 h before surgery(P<0.05). Among the patients with Chiari malformation type I, there were 19 cases with intracranial infection after surgery, and 61 cases without infection. Multivariate Logistic regression analysis showed that older age, longer operation time, no use of antibiotics and postoperative spinal fluid leakage were risk factors for postoperative intracranial infection in patients with Chiari malformation type I (P<0.05). Conclusion: PC-MRI can effectively analyze the changes of cerebrospinal fluid hydrodynamics in patients with Chiari malformation type I before and after surgery. Risk factors for postoperative intracranial infection in patients with Chiari malformation type I include older age, longer operation time, no use of antibiotics, and postoperative spinal fluid leakage. [ABSTRACT FROM AUTHOR]

Objective To explore the influencing factors of intracranial infection in patients after ventricular drainage, and to build and verify the established risk prediction model. Methods A retrospective analysis was carried out on 757 patients who underwent external ventricular drainage (EVD) in our department from January 2010 to December 2018. According to the occurrence of postoperative intracranial infection, they were divided into intracranial infection group (n=79) and non-intracranial infection group (n=678). Their clinical data were collected and compared. Univariate analysis and multivariate logistic regression analysis were used to explore the influencing factors of intracranial infection after ventricular drainage. A risk prediction model was established and anomogram was drawn. Another 148 patients with EVD in our hospital from 2019 to 2020 were selected as the validation group, including 8 patients with intracranial infection after surgery and 140 patients without. The area under receiver operating characteristic (ROC) curve and Hosmer-Lemeshow test were employed to evaluate the prediction efficacy of the model. Results Hypoproteinemia, lumbar cisternae drainage, EVD time >7 d, pulmonary infection, tracheotomy, open craniocerebral trauma, surgical incision infection, and complicated with bacteremia/sepsis were influencing factors of intracranial infection after EVD. The validation results for the prediction model showed that the area under ROC curve for the risk of postoperative intracranial infection was 0.923 in the modeling group and 0.920 in the verification sample (P < 0.01). As to the Hosmer-Lemeshow test, the P value was 0.450 in the modeling patients and 0.877 in those from the verification group. Conclusion There are 8 high-risk factors for incidence of intracranial infection in patients after EVD. Our established model can effectively predict the occurrence of intracranial infection in these patients.

Objective To investigate the diagnosis and treatment of isolated fourth ventricle after intracranial infection. Methods The clinical data of 4 patients with isolated fourth ventricle admitted to the Department of Neurosurgery, General Aviation Hospital from February 2018 to January 2020 were retrospectively analyzed, and the relevant literature was reviewed. Results Four cases of isolated fourth ventricle were all secondary to intracranial infection, and all had undergone lateral ventricular drainage. The clinical manifestations were coma, delayed pupillary light reflex, shallow and rapid respiration, fluctuating heart rate and blood pressure, dysphagia, salivation, increased muscle tone, and presence of denervation and rigidity. Two cases needed a breathing machine to assist with respiration, and norepinephrine was used to maintain blood pressure. Among them, 2 patients underwent endoscopic exploration and showed the formation of pus coating and pseudomembranous separation in the fourth ventricle. All 4 patients underwent external drainage from the fourth ventricle to the abdominal wall. Among them, 1 patient underwent simultaneous drainage from the annular cistern cyst to the abdominal wall, and 1 patient complicated with spinal cord subarachnoid abscess and soft tissue suppurative infection in the craniotomy area underwent simultaneous drainage from the pus cavity, epidural drainage, and lumbar cistern drainage. During extracorporeal drainage, intracranial infection was treated with drainage and irrigation. After surgery, the pupil reflex, respiration, blood pressure, salivation, gastroparesis, muscle tone, and denervation rigidity of the patient were significantly improved. Both vasopressor drugs and ventilator therapy were discontinued. One patient was awake after surgery, and three patients were still in a coma state (including two patients with severe bilateral cerebral hemisphere and midbrain injury). After the intracranial infection was cured, a ventriculoperitoneal shunt was performed, with 2 patients using a shunt pump (30 mmH₂O) and 2 patients not using a shunt pump, using a straight tube for shunt. Conclusions For patients with intracranial infection and isolated hydrocephalus of the fourth ventricle, if diagnosed by imaging and accompanied by corresponding clinical symptoms, early surgery should be performed to relieve the compression of the fourth ventricle on the brainstem, which is very important to improve the prognosis of patients. [ABSTRACT FROM AUTHOR]

Objective: To explore the relationship between intracranial infection and hemorheology in patients with type 2 diabetes mellitus (T2DM) and cerebral hemorrhage after minimally invasive surgery. In the patients with T2DM and cerebral hemorrhage, 50 patients with intracranial infection after minimally invasive surgery in the hospital were enrolled as infection group between January 2017 and December 2021. According to scores of Glasgow Coma Scale (GCS) at admission, they were divided into mild group (GCS ≥9 points, n=31) and severe group (GCS <9 points, n=19). According to case control study, 50 patients without intracranial infection during the same period were enrolled as control group. The changes of hemorheology indexes in different groups were analyzed. The predictive efficiency of postoperative hemorheology indexes for prognosis of intracranial infection was evaluated by ROC curves. The number of drainage tubes, indwelling time of drainage tube and cerebrospinal fluid leakage in infection group were higher than those in control group (P<0.05). The whole blood low-cut and high-cut viscosity, plasma viscosity and erythrocyte aggregation index in infection group were higher than those in control group (P<0.05). The whole blood low-cut and high-cut viscosity, plasma viscosity and erythrocyte aggregation index in severe group were higher than those in mild group (P<0.05), which were higher in poor prognosis group than good prognosis group (P<0.05). The results of ROC curves analysis showed that AUC and best cut-off values of whole blood low-cut viscosity, whole blood high-cut viscosity, plasma viscosity and erythrocyte aggregation index for predicting the prognosis of postoperative intracranial infection were (0.698, 0.837, 0.690, 0.666) and (10.22 mPa·s, 5.20 mPa·s, 5.05 mPa·s, 14.10), respectively. The coagulation function and hemorheology indexes abnormally increase in intracranial infection patients with T2DM and cerebral hemorrhage after minimally invasive surgery, which have certain predictive value for conditions and prognosis. [ABSTRACT FROM AUTHOR]

Copyright of Imaging Science & Photochemistry is the property of Imaging Science & Photochemistry Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the clinical value of serum lipoprotein ( a), myelin basic protein ( MBP) and calcitonin gene-related peptide ( CGRP) combined in the diagnosis of early infection after craniotomy in patients with cerebral hemorrhage. Methods 265 patients with intracerebral hemorrhage who were treated by craniotomy hematoma removal in Mianyang Central Hospital from January 2017 to January 2020 were included in the case group.The case group was divided into infection group and normal group according to whether there was intracranial infection after craniotomy. At the same time, 30 healthy volunteers were included in the control group. Serum Lp ( a), MBP and CGRP levels in the control group, normal group and infection group were detected and compared, and their value in diagnosing intracranial infection was analyzed. Results The serum levels of Lp ( a), MBP and CGRP in the case group were significantly higher than those in the control group ( P ＜ 0. 05) . Among the 265 patients undergoing craniotomy for hematoma removal, a total of 25 patients developed intracranial infection, with an infection rate of9. 43% ( 25/265) . The operative time of the infected group was significantly different from that of the normal group ( P ＜0. 05), and there was no significant difference in other data ( P ＞0. 05) . The levels of Lp ( a), MBP and CGRP in the infected group were significantly higher than those in the normal group ( P ＜ 0. 05) . The correlation analysis showed that the serum Lp ( a), MBP and CGRP levels in the infected group were positively correlated with the CSF white blood cell levels ( P ＜ 0. 05) . The ROC curve showed that when serum Lp ( A), MBP and CGRP were applied alone, CGRP was the most effective in the diagnosis of intracranial infection, with AUC = 0. 788 and 95% CI = 0. 699-0. 878, the AUC of CGRP + Lp ( A) and CGRP + MBP in diagnosing intracranial infection was 0. 810 and 0. 826, respectively. And the combined application of the three was the most effective, with AUC = 0. 918 and 95%CI = 0. 865-0. 972. Conclusion The levels of serum Lp ( a), MBP and CGRP in patients with intracranial hemorrhage treated with craniotomy are abnormally elevated, and the concentrations of serum Lp ( a), MBP and CGRP in patients with intracranial infection are higher than those in patients without intracranial infection. The combined application of the three has a good effect in the diagnosis of intracranial infection. [ABSTRACT FROM AUTHOR]

Ventriculo-peritoneal shunt is a conventional surgical method for the treatment of hydrocephalus. However，postoperative infections caused by various reasons lead to blockage of the shunt tube，which often requires shunt revision surgery. A case of recurrent hydrocephalus infection was admitted to our hospital. The infection could not be cured after repeated placement and replacement of the shunt tube until all the implants in the body were removed，the shunt tube was replaced after sufficient antiinflammatory treatment. During follow-up the symptoms were stable. Revision or replacement of the ventriculo-peritoneal shunting requires reliable clinical evidence to reduce the possibility of infection recurrence. [ABSTRACT FROM AUTHOR]

Copyright of Imaging Science & Photochemistry is the property of Imaging Science & Photochemistry Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the changes and significance of heparin binding protein (HBP) and high mobility group protein B-1 (HMGB-1) in the cerebrospinal fluid of patients with secondary intracranial infection after craniocerebral surgery. Methods Totally 141 patients undergoing craniocerebral surgery were collected, and they were divided into the infection group (58 cases) and non-infection group (83 cases) according to whether they had secondary intracranial infection within one month after operation. The levels of HBP and HMGB-1 in the cerebrospinal fluid were detected by enzyme-linked immunosorbent assay. Logistic regression was used to analyze the influencing factors for secondary intracranial infection after craniocerebral surgery. The receiver operating characteristic (ROC) curve was drawn to evaluate the predictive value of HBP and HMGB-1 for secondary intracranial infection. Results Univariate analysis showed that the proportions of age≥60 years, mechanical ventilation of tracheal incision, cerebrospinal fluid leakage of postoperative incision, operation time ≥4 hours and preoperative GCS score < 8 in the infection group were higher than those in the non-infection group, and the levels of HBP and HMGB-1 in the cerebrospinal fluid of the infection group were higher than those of the non-infection group (all P < 0. 05). Multivariate Logistic regression analysis showed that age, tracheal incision mechanical ventilation, postoperative incision cerebrospinal fluid leakage, operation time, preoperative GCS score, HBP and HMGB-1 were independent risk factors for secondary intracranial infection after craniocerebral surgery (OR = 1. 146, 1. 254, 1. 273, 1. 237, 1. 471, 1. 697, and 1. 441, respectively; all P <0. 05). ROC curve showed that the AUC of HBP in predicting intracranial infection after craniocerebral surgery was 0. 787, and the sensitivity and specificity were 0. 81 and 0. 76, respectively; the AUC of HMGB-1 was 0. 749, and the sensitivity and specificity were 0. 76 and 0. 75, respectively; the AUC of HBP combined with HMGB-1 was 0. 833, the sensitivity and specificity were 0. 87 and 0. 72, respectively; the AUC of combined detection in predicting intracranial infection was greater than that of a single index (all P < 0. 05). Conclusion The levels of HBP and HMGB-1 in cerebrospinal fluid of patients with secondary intracranial infection after craniocerebral surgery increase, and timely detection before operation is helpful to predict the risk of secondary intracranial infection after surgery. [ABSTRACT FROM AUTHOR]

Objective To investigate the reasonable treatment effect of perioperative hydrocephalus in patients with posterior fossa tumor. Methods The clinical data of 241 patients who underwent resection of posterior fossa tumors were analyzed retrospectively, of which 14 patients were excluded because of postoperative complications with other systemic infections. The patients with posterior fossa tumor complicated with hydrocephalus were divided into preoperative lumbar cistern drainage 1（ PLCFD1） group（ 22 cases） and no preoperative lumbar cistern drainage 1（ NPLCFD1） group（ 45 cases）. 227 patients with posterior fossa tumors were divided into preoperative lumbar cistern drainage 2（ PLCFD2） group（ 43 cases） and no preoperative lumbar cistern drainage 2（ NPLCFD2） group（ 184 cases）. The clinical data of the two groups were compared and analyzed. Results In this group,67 patients with posterior cranial fossa tumor complicated with hydrocephalus, and the remission rate of hydrocephalus was 94. 0%.The remission rate of early postoperative hydrocephalus in PLCFD1 group（ 86. 4%） was significantly higher than that in NPLCFD1 group（ 62. 2%）（ P = 0. 043）. The postoperative intracranial infection rate in PLCFD2 group（ 23. 3%）was significantly lower than that in NPLCFD2 group（ 41. 3%）（ P = 0. 028）. There was no significant difference in antibiotic use time between PLCFD2 group[14（ 10. 75-20. 50） d]and NPLCFD2 group [17（ 13. 25-22. 75） d]（ P = 0. 134). Conclusions Surgical treatment of hydrocephalus is not recommended in patients with posterior cranial fossa tumors complicated with hydrocephalus, except for obvious acute intracranial hypertension and ineffective drug treatment; In the patients with subtotal resection or above, only a small number of patients with hydrocephalus need further surgical treatment. Proper lumbar cistern drainage during and after operation can promote the early clearance of inflammatory and bloody cerebrospinal fluid in patients with posterior fossa tumor complicated with hydrocephalus after tumor resection, so as to reduce the incidence of postoperative hydrocephalus and reduce the incidence of intracranial infection after posterior fossa tumor resection. [ABSTRACT FROM AUTHOR]

Objective To study the treatment and efficacy of intracranial infection caused by multidrugresistant Acinetobacter baumannii. Methods 20 patients with intracranial infection caused by multidrug-resistant Acinetobacter baumannii were treated with conventional intraventricular and lumbar cistern drainage, and tigecycline combined with Cefoperazone/sulbactam for 12 - 42 days. The clinical manifestations were observed before and after treatment. The cerebrospinal fluid was examined by lumbar puncture. The levels of serum Creactive protein ( CRP), procalcitonin (PCT), S-100B protein and tumor necrosis factor ( TNF) -a level were detected. Results After anti infection treatment, 16 cases were cured and 4 cases were markedly effective. The number of cerebrospinal fluid cells and biochemical indexes were normal, and the bacterial culture was negative; The total effective rate was 100%. The number of white blood cells, the ratio of polynuclear cells an d the content of protein in CSF after 1 week of treatment were significantly lower than those before treatment, while the content of sugar was higher than that before treatment; Serum CRP, PCT, S-100B protein, TNF- a The level was lower than that before treatment; The differences were statistically significant(P < 0.01 - 0.001 ). During the treatment, the liver and kidney function, blood and urine routine were normal, and there were n o adverse reactions such as leucopenia, diarrhea, convulsion, allergy and so on. After stopping anti infective treatment for 2 months, no reinfection occurred. Conclusion The intracranial infection caused by multidrug-resistant Acinetobacter baumannii has a serious condition and high mortality. The key to successful treatment is to make a reasonable treatment plan and choose effective antibiotics. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Modern Laboratory Medicine is the property of Journal of Modern Laboratory Medicine Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

bjective: To study the effect of minimally invasive drilling and drainage on the short-term curative effect of patients with hypertensive cerebral hemorrhage, intracranial infection and hematoma re-enlargement. Methods: 81 patients with hypertensive intracerebral hemorrhage from March 2017 to February 2019 were selected. According to the random number table, they were divided into observation group (n=42) and control group (n=39). The control group was treated with conventional craniotomy and hematoma removal, and the observation group was treated with minimally invasive drilling and drainage. Observe the therapeutic effects of the two groups, the amount of hematoma, myelin basic protein (MBP), central nervous system specific protein S100 levels, NIHSS, GCS scores, and adverse reactions. Results: After treatment, the total effective rate of the observation group was significantly higher than that of the control group [92.86% (39/42) vs 69.23% (27/39)] (P<0.05); hematoma volume, MBP, and S100 levels were significantly lower Control group [(9.32±2.70) m L vs (15.51±3.01) m L, (3.65±0.52) μg/L vs (4.20±0.71) μg/L, (0.98±0.26) μg/L vs (1.39±0.35) )Μg/L] (P<0.05); NIHSS score was significantly lower than the control group [(3.90±2.71) points vs (6.34±1.42) points (P<0.05); GCS score was significantly higher than the control group [(14.84±3.52) ) Points vs (10.69±3.98) points] (P<0.05); the total incidence of adverse reactions was significantly lower than that of the control group [9.52% (4/42) vs 38.46% (15/39)] (P<0.05). Conclusion: The short-term curative effect of minimally invasive drilling and drainage in the treatment of patients with hypertensive cerebral hemorrhage is significant. The hematoma is completely removed, which can effectively improve the brain nerve defect, reduce intracranial infection, and promote the recovery of the prognosis. [ABSTRACT FROM AUTHOR]

Objective To explore the treatment of multidrug-resistant Gram-negative ventriculitis after craniocerebral surgery. Metltods The clinical data of 5 patients of multidrug-resistant Gram-negative bacteria ventriculitis after craniocerebral surgery were retrospectively analyzed. 3 patients were infected after craniocerebral trauma surgery, 1 was after removal of spontaneous cerebral hematoma, and 1 was after resection of the right cavernous sinus tumor. Cerebrospinal fluid culture results showed that 2 patients had multi-drug-resistant acinetobacter baumannii and 3 had carbapenem-resistant Klebsiella pneumonia. All patients underwent Ommaya sac placement + lateral ventricular drainage and intraventricular lavage. At the same time, corresponding antibiotics were used according to bacterial drug sensitivity results. After 3 - 6 months, all patients were followed up to evaluate the treatment effect. Results 2 patients with carbapenem-resistant pneumonia Klebsiella ventricularitis died during the course of the treatment, 3 patients were cured clinically. Conclusions Multi-drug resistant Gram-negative bacteria ventriculitis after craniocerebral surgery is a very serious complication. The cure rate of ventriculitis can be improved by timely placement of Ommaya capsule and lateral ventricular drainage, and intraventricular irrigation with antibiotics. [ABSTRACT FROM AUTHOR]

Objective To establish a two-dimensional high-performance liquid chromatography method for the determination of tigecycline in human cerebrospinal fluid, which can be used for the drug monitoring in patients with intracranial infection. Methods The quantification was carried out by an external standard method. The first-dimension column was a Aston SNX5 phenyl chromatographic column (50 mm×4.6 mm, 5 μm) with ammonium phosphate (pH was adjusted with ammonium hydroxide to 7.5)-methanol (45∶55, V/V) as the mobile phase and the flow rate was 1.2 ml/min. The second-dimension chromatographic column was Aston SC5 C18 (275 mm×4.6 mm, 5 μm), with ammonium phosphate (pH was adjusted with ammonium hydroxide to 7.4)-ammonium phosphate (pH was adjusted with ammonium hydroxide to 3.0)- acetonitrile (30∶50∶20, V/V/V) as the mobile phase and the flow rate was 1.0 ml/min. The detection wavelength was 340 nm. The temperature was 40 ℃ and the injection volume was 200 μl. Results The calibration curve of tigecycline showed good linearity from 64.5 to 1 290.0 ng/ml in human cerebrospinal fluid (r=0.999 8). The RSD of intra and inter-day precision were less than 5.0% with the detection accuracy of 98.80%−106.51%. Conclusion This method is simple, quick, accurate, specific and sensitive. It meets the requirements of tigecycline determination in clinical human cerebrospinal fluid, which offers the individualized therapeutic assurance for patients with intracranial infection. [ABSTRACT FROM AUTHOR]

Objective To explore the therapeutic effects of intracranial infection with extensively drug resistant Acinetob部ter baumanni ( XDRAB ) by using high-dose tigecycline. Methods The clinical data of 1 case of intracranial infection with XDRAB, especially the treatment process of using high-dose tigecycline, were analyzed retrospectively and the related literatures were reviewed. Results After the occurence of XDRAB intracranial infection, intravenous administration of tigecycline at regular dose was ineffective. The intr缸ranial infection was controlled and cured by adjusting the therapeutic schedule to intravenous high-dose tigecycline. Conclusion Intravenous high-dose tigecycline can achieve good therapeutic effects for the intracranial infection with XDRAB. [ABSTRACT FROM AUTHOR]

Objective To investigate the related risk factors and preventive measures of intracranial infection in patients with recurrent intracranial glioma. Methods The clinical data of patients with recurrent glioma surgery from March 2007 to March 2015 were retrospectively analyzed. The univariate and multivariate logistic regression analysis was performed on the risk factors of in tracranial infection. Results Univariate analysis showed that the combination o f diabetes,organ dysfunction,pro longed bed rest be fore surgery, and t he interval between secondary operations less than or equal to 6 months, the preoperative Kamofsky functional status ( KPS) score was less than or equal to 70 points, the operation time was greater than or equal to 4 hours, preoperative radio therapy, preoperative chemotherapy, postoperative intensive care were significantly related to intracranial infection after reoperation of recurrent glioma. Multivariate logistic regression analysis showed t hat the independent risk factors for intracranial infection in patients with recurrent glioma after the second operation were from strong to weak: concomitant diabetes, KPS score less than or equal to 70 points before surgery, and operation time greater than or equal to 4 hours. Conclusion The main risk factors for intracranial infection in t he second operation of recurrent glioma are combined diabetes, preoperative KPS score of 70 or less, and operation time of 4 hours or more. Taking preventive measures according to the cause is the key to reduce the rate of intracranial infection. [ABSTRACT FROM AUTHOR]

Objective To explore the administration of tigecycline for intracranial infection of multiple drug resistant Acinetobacter Baumannii(MDRAB). Methods The clinical data of 6 patients with intracranial MDRAB infection admitted in Department of Neurosurgery, The Fourth Cilnical Center, PLA General Hospital from October 1st 2014 to August 1st 2016 were analyzed retrospectively. The results of the appearance, bacteria and drug sensitive test of cerebral spinal fluid(CSF) of these patients were extracted. Based on these results, tigecycline was administered 50 mg 1/12 h intravenously(100 mg for the first administration) companying with some basic treatment. Another 10 mL tigecycline with the concentration of 0.5 mg/mL was administered 1/12 h intrathecally. The therapeutic period was 9-21 days and the average duration was 14 days. The results of the therapy were observed. Results 6 cases of intracranial MDRAB infection were cured after treatment. No significant nervous function disorders were observed. The follow-up period was 1 year. During this period, no infection recurrence was observed in these patients. Conclusions The drug resistant rate of tigecycline is low in the clinical practice and tigecycline is more sensitive to MDRAB. But tigecycline is hard to pass through the blood brain barrier. When intracranial MDRAB infection occurred, the effectiveness of tigecycline was not satisfactory for simply venous administration in some cases. Simultaneously intrathecally administration of tigecycline has better effectiveness, and the nervous function disorders due to the drug are minimal. [ABSTRACT FROM AUTHOR]

Copyright of Journal of China Medical University is the property of Journal of China Medical University Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

ObjectiveTo explore the treatment scheme for intracranial infection with extensively drug-resistant Acinetobacter baumannii and the technique for early diagnosis. MethodsThe clincal data of a case of intracranial infection with extensively drug-resistant Acinetobacter baumannii after craniotomy for craniocerebral trauma, the treatment scheme of extensively drug-resistant Acinetobacter baumannii intracranial infection was diacussed. Result During the hospitalization of the patient, the intracranial infection was confirmed by the next-generation sequencing (NGS) and procalcitonin (PCT) testing in the CSF. The condition of infection was getting better after two weeks treatment by adjusting the scheme to tigecycline+polymyxin B intravenously and lumbar cistern drainage with gentamicin flushing, combined with intrathecal and intraventricular tigecycline+polymyxin B injection. Conclusion For the intracranial infection with extensively drug-resistant Acinetobacter baumannii, injecting tigecycline+polymyxin B intravenously and lumbar cistern drainage with gentamicin flushing, combined with intrathecal and intraventricular tigecycline+polymyxin B injection can be an effective therapeutic option. [ABSTRACT FROM AUTHOR]

Objective To analyze the risk factors associated with intracranial infection after craniocerebral surgery, and to provide evidence for reducing intracranial infection after craniocerebral surgery. Methods The literatures related to intracranial infections after craniocerebral surgery included in Web of Science, PubMed, Scopuss, Karger, EBSCO+ Medline, Embase, China Knowledge Network, Wanfang, and Weipu Database were retrieved. The search time was from 2009 to 2018. The literature was evaluated using the Newcastle-Ottawa Scale(NOS)scale and the data was analyzed using STATA12. 0. Results Thirty eligible studies were eventually included in a total of 36 773 patients. The analysis showed that risk factors for intracranial infection after craniocerebral surgery included incision type, secondary surgery, postoperative GCS score, postoperative cerebrospinal fluid leakage, operative time, and intraoperative indwelling drainage. Age, diabetes, preventive use of antibiotics, surgical sites, and emergency surgery were not associated with intracranial infection. Perioperative use of hormones and intracranial infections after craniocerebral surgery were controversial. Conclusion Avoiding reoperation, cerebrospinal fluid leakage, unnecessary drainage, and shortening the operation time will help reduce the incidence of intracranial infection. For patients with contaminated incision and postoperative GCS of less than 8 points, it is necessary to be alert to intracranial infection after craniocerebral operation. [ABSTRACT FROM AUTHOR]

ObjectiveTo explore clinical characteristics, prevention and treatment of advanced infection as a complication of ventriculoperitoneal (VP) shunt. MethodsThe clinical data of 4 patients with hydrocephalus underwent VP shunt admitted in Peking Union Medical College Hospital were analyzed retrospectively. Results3 cases of abdominal infection and 1 of multisystemic infection were presented, all of which were patients developing hydrocephalus after neurosurgery. 2 of them were cases of adhesive intestinal obstruction and intracranial infection, 1 case was multiple abdominal abscesses, while the other one was a case of intracranial infection combined with urinary tract infection and pulmonary infection. These 4 patients were treated effectively by shunt removal and intravenous administration of antibiotics and there was no relapse during the 6-month follow-up. ConclusionsVP-shunt related advanced infection has non-specific clinical manifestations and is often associated with intracranial infection. Staphylococcus is one of the major pathogens. Shunt removal or externalization and systematic antibiotics treatment is usually required. [ABSTRACT FROM AUTHOR]

Copyright of Practical Pharmacy & Clinical Remedies is the property of Editorial Department of Practical Pharmacy & Clinical Remedies and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To evaluate the risk factors for postoperative intracranial neurosurgical infection and explore the diagnostic value of serum and cerebrospinal fluid (CSF ) marks for intracranial infection. Methods 321 patients were divided into two groups, infection group and no infection group. Risk factors predicating intracranial infection were collected as gender, age, site of tumor, duration of operation, blood transfusion and external ventricular drain. Serum and CSF procalcitonin (PCT), white blood cell (WBC) counts, lactic acid (LA) and glucose were detected and analyzed respectively.Results External ventricular drain was an independent risk factor for postoperative intracranial neurosurgery infection (P =0.016). Serum and CSF LA, CSF WBC counts and CSF glucose could identify intracranial infection.However, there was no significant difference for serum and CSF PCT between the two groups. CSF glucose has a higher sensitivity (96.4%) and specificity (75.7%). Conclusion Serum and CSF LA, CSF WBC counts and CSF glucose could be proposed as effective diagnostic markers for postoperative intracranial neurosurgical infection. The diagnostic value of PCT wasn't detected in our study, further studies are needed to confirm the importance of PCT in diagnose intracranial infection. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To systematically review the efficacy of intrathecal gradient injection of vancomycin in treatment of intracranial staphylococcal infection. METHODS: Literature relevant to intrathecal gradient injection of vancomycin in treatment of intracranial staphylococcal infection published before Dec. 31st in 2014 from databases of Pubmed, Cochrane Library, EMbase, CNKI, Wanfang and VIP were retrieved, strict standard of literature screening and quality evaluating were adopted to obtain the valid data, and then Meta-analysis was conducted on the cure rate, body temperature, leukocyte count and biochemical examination results of cerebrospinal fluid in intracranial staphylococcal infection patients. RESULTS: Totally 4 literatures were involved, including 173 patients. The results of meta-analysis showed that, compared with the control group and before treatment, intrathecal gradient injection of vancomycin in treatment of intracranial staphylococcal infection could significantly decrease the body temperature (Z =12. 49, MD = 2. 21, 95% CI = 1. 87-2. 56, P <0. 000 01), leukocyte count (Z = 30. 17, MD = 38. 38, 95% CI = 35. 88-40. 87, P < 0. 000 01), and protein content in cerebrospinal fluid (Z = 12. 19,MD = 0. 64,95% CI = 0. 54-0. 75, P < 0. 000 01), and increase the content of glucose (Z = 9. 51, MD =- 1. 03, 95% CI =- 1. 25-0. 82, P < 0. 000 01) and chloride (Z = 16. 58, MD =- 43. 11, 95% CI =- 48. 21-38. 02, P = 0. 80) in cerebrospinal fluid for intracranial staphylococcal infection patients, respectively. CONCLUSIONS: Intrathecal gradient injection of vancomycin in treatment of intracranial staphylococcal infection is significant. [ABSTRACT FROM AUTHOR]

Copyright of Practical Pharmacy & Clinical Remedies is the property of Editorial Department of Practical Pharmacy & Clinical Remedies and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To explore methods and effects in conservative management of patients with infected but functioning ventriculoperitoneal intracranial shunts. Methods The clinical data of 13 patients treated conservatively for ventriculoperitoneal shunt infection between 2005 and 2012 were analyzed retrospectively. Treatment was based on the administration of a combination of lumbar drainage, intraventricular and systemic antibiotics. Results 13 patients were cured after treated with antibiotics for 10 to 21 days, and kept functioning shunts. There was no toxicity related to intraventricular antibiotics administration. The follow-up from 10 to 72 months showed they were free from recurrent infection and shunt blockage. Conclusion The conservative management can cure patients with shunt infections, avoids surgical intervention, with its attendant risks, and is safe and reliable. [ABSTRACT FROM AUTHOR]

Objective To explore the treatment scheme for intracranial infection induced by extensively drug resistant Acinetobacter baumanni ( XDRA) after craniotomy. Methods The treatment process of a patient who acquired intracranial infection induced by XDRA was analysed retrospectively, which involved choice and dose of antibacterials. Results rlbe intracranial infection was controlled effectively at the end by changing the antibiotics scheme to intravenous " tigecycline + cefperazone-sulbaetam + minocycline ", combined with intrathecal and intraventricular tigecycline injection. Conclusion Intrathecal and intraventricular tigecycline injection could achieve good effect of controlling intracranial infection. [ABSTRACT FROM AUTHOR]

OBJECTIVE:To probe into the clinical efficacy of antibiotics for systemic use and intrathecal injection in treatment of intracranial infection after craniocerebral injury. METHODS:56 patients with intracranial infection after craniocerebral injury admitted into Tie Mei Coal Group General Hospital from Feb. 2015 to Feb. 2016 were selected and divided into observation group and control group via parity law, with 28 cases in each group. The control group was treated with antibiotics for systemic use, while the observation group was given antibiotic for intrathecal injection based on the control group, the white blood cell count and change of albumin level of two groups were observed, the healing time and treatment effect of two groups were compared. RESULTS:After treatment, the white blood cell count and albumin level of two groups were obviously improved than those of before treatment, with statistically significant difference (P<0.05); but there was no statistically significant difference between two group (P>0.05). The total effective rate of observation group was 96.43% (27/28), that of the control group was 92.86 (26/28), with no statistically significant difference in two groups (P>0.05). The symptom disappearance time of observation group was (12.16±2.34) d, that of the control group was (5.18±1.06) d, with statistically significant difference (P<0.05). CONCLUSIONS:The efficacy of antibiotics for systemic use and intrathecal injection in treatment of intracranial infection after craniocerebral injury is remarkable, which can shorten hospital stays. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To probe into the efficacy of cerebrospinal fluid replacement combined with intrathecal injections of vancomycin and dexamethasone in treatment of postoperative intracranial infection and effects on biochemical indexes. METHODS： 60 patients with intracranial infection after operation admitted into Zhumadian Central Hospital from Oct. 2014 to Oct. 2016 were selected to be divided into observation group and control group via the random number table， with 30 cases in each. The control group group were treated with cerebrospinal fluid replacement and intravenous ceftriaxone，while the observation group were given cerebrospinal fluid replacement the intrathecal injection of vancomycin，dexamethasone. The efficacy and changes of biochemical indexes of two groups were observed. RESULTS： After treatment，the intracranial pressure，white blood cell count，and content of protein， glucose in observation group were significantly higher than those of control group，with statistically significant difference (P <0. 05) . There was no statistical significance between two groups in the incidence of adverse drug reactions (P > 0. 05). CONCLUSIONS： The efficacy of cerebrospinal fluid replacement combined with intrathecal injections of vancomycin and dexamethasone in treatment of postoperative intracranial infection is significant，which can improve the biochemical indexes with few adverse drug reactions and high safety. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To probe into the clinical effects of vancomycin intrathecal injection combined with external drainage of lumbar cistern in treatment of intracranial infection. METHODS: 108 patients with intracranial infection admitted into Yongcheng People’s Hospital from Oct. 2013 to Dec. 2014 were selected to be divided into observation group and control group via the random number table, with 54 cases in each. The control group were treated with vancomycin intrathecal injection alone, while the observation group received vancomycin intrathecal injection combined with external drainage of lumbar cistern. The clinical effects and infection control of two groups were observed. RESULTS: After treatment, the total effective rate of observation group was 98.15% (53/54), significantly higher than that of control group 75.93% (41/54), with statistical significance (P<0.05). Meanwhile, the intracranial pressure of observation group was (120.54 ±19.11) mmHg (1 mmHg =0.133 kPa), significantly lower than that of control group [(176.38 ±23.75) mmHg], with statistical significance (P<0.05 ). Compare the two groups after treatment in patients with cerebrospinal fluid white blood cell count, protein content and glucose content in the aspect (P<0.05). CONCLUSIONS: The clinical effects of vancomycin intrathecal injection combined with external drainage of lumbar cistern on patients with intracranial infection are significant, which can improve the clinical efficacy and symptoms of intracranial infection, lower the intracranial pressure and improve the living quality of patients. It is worthy of application and promotion. [ABSTRACT FROM AUTHOR]

Objective To explore the risk factors related to the intracranial infection(ICI)in severe brain injury patients after craniotomy in order to provide the basis for its prevention and treatment.Methods The clinical data of 186 patients with ICI among 2088 severe brain injury patients who underwent a craniotomy from January 2008 to January 2014 in our department,were analyzed retrospectively.The significant risk factors shown by the single factor analysis(χ2 text )were analyzed by multivariate logistic regression analysis. Results The multivariate logistic regression analysis showed that the independent risk factors related to ICI after the craniotomy included external ventricular drainage(OR =5.687),cerebrospinal fluid leakage,more than 6 hours operative duration repeated operation,accompanied with diabetes mellitus,and GCS score <5(OR >1).Conclusion ICI in severe brain injury patients after the craniotomy related to a variety of risk factors and it may be reduced by targeted prevention. [ABSTRACT FROM AUTHOR]

Objective: To summarize the common clinical types of cerebrospinal fluid（CSF） rhinorrhea and key points of transnasal endoscopic repair of CSF rhinorrhea. To evaluate clinical effects. Method: In 29 patients with cerebrospinal fluid rhinorrhea, 9 patients with traumatic CSF rhinorrhea, 10 patients with spontaneous CSF rhinorrhea, 7 patients with CSF rhinorrhea after tumour excision, and 3 patients with iatrogenic CSF rhinorrhea. All the 29 patients were treated with transnasal endoscopic repair of CSF rhinorrhea. Result: There were 25 patients were successfully repaired at one time. Three patients developed intracranial infection and 2 patient developed pneumocephalus after surgery, all of them were cured with conservative treatment. All the patients who were followed-up for more than half a year had no recurrence. Conclusion: Transnasal endoscopic repair of CSF rhinorrhea is safe and effective, the success rate of operation is high, it is not easy to recur, and the complications are few. It can be used as the first choice for repairing of CSF rhinorrhea and effective prevention measures. Accurate location of leak, appropriate repair, effective reconstruction of the skull base, continuous drainage of the lumbar cistern when necessary and active prevention of intracranial infection are critical to the success of operation., Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose., (Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.)

Objective: To investigate the clinical features and risk factors for poor prognosis in patients with intracranial Acinetobacter baumannii infection. Methods: Retrospective analysis of data of patients who were hospitalized in the First Affiliated Hospital of AnHui Medical University between January 2011 and December 2017, and whose cerebral spinal fluid samples were positive for Acinetobacter baumannii and who were clinically demonstrated as intracranial infection during hospitalization was performed. Risk factors for poor prognosis were analyzed using single factor analysis and logistic regression analysis. Results: A total of 50 patients were included, with poor prognosis rate of 58% (29/50).92% of patients had history of craniotomy or operation of site adjacent to brain.Major type of intracranial infection was purulent meningitis.Fever rate was 100%.Multidrug resistant Acinetobacter baumannii accounted for 89.01%. Sensitivity to meropenem was only 9.09%.Shock, multi-drug resistant bacteria and no intrathecal injection were risk factors for poor prognosis of patient.Multi-factor logistic regression analysis showed "no intrathecal injection" was independent risk factor for poor prognosis of patients with intracranial Acinetobacter baumannii infection. Conclusions: that induced intracranial infection is mostly highly drug-resistant bacterium, with high risk of post-infection poor prognosis.Clinically, it is essential to take proper peri-operative measures and early identify occurrence of intracranial infection.Reasonable application of anti-infection drug and external ventricle drainage, especially intrathecal injection of aminoglycosides, can be promoted as a kind of safe and effective means.Acinetobacter baumannii that induced intracranial infection is mostly highly drug-resistant bacterium, with high risk of post-infection poor prognosis.Clinically, it is essential to take proper peri-operative measures and early identify occurrence of intracranial infection.Reasonable application of anti-infection drug and external ventricle drainage, especially intrathecal injection of aminoglycosides, can be promoted as a kind of safe and effective means.