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ObjectiveTo investigate and analyze the epidemiological characteristics of a wild mushroom poisoning event in Qinhuangdao City, identify the species of poisonous mushroom, summarize the experience of investigation and treatment, and put forward prevention and control measures, and provide reference for the treatment and prevention of wild mushroom poisoning patients.MethodsThe poisoning events were analyzed by using the method of epidemiological investigation, morphological identification and mushroom toxin detection.ResultsFour villagers in Qinhuangdao city had nausea, abdominal pain, diarrhea, sweating and shivering after eating wild mushrooms. Patients were treated with vomiting, gastric lavage, atropine and other symptomatic treatment in the hospital, and the prognosis of the patients was good. After morphological identification and toxin detection, it was determined that food poisoning caused by mushroom of inocybe.ConclusionThis is the first reported poisoning event caused by mushroom of inocybe in Hebei Province. The reason of poisoning was misguided by the Internet and poor self-awareness of food safety. Therefore, publicity and education should be strengthened, enhancing the awareness to prevent the poisoning of wild mushroom.

Objective: To investigate the relationship between vitamin D binding protein gene rs2282679 A/C polymorphism with blood vitamin D levels., Methods: A total of 286 eligible subjects were selected from one university in Hebei Province. Serum 25-hydroxylated vitamin D levels were measured by liquid chromatography-mass spectrometry, and gene chip was used for genotyping of rs2282679 locus. Statistical analysis was performed using R software., Results: A total of 285 participants in the study completed the experiment, and result indicated that the distribution of the rs2282679 locus A/C polymorphism in the participants was consistent with the Hardy-Weinberg equilibrium. The genotype of rs2282679 was significantly associated with serum vitamin D insufficiency and deficiency(P=0. 031). Allele A was a risk factor for vitamin D insufficiency and deficiency. The OR value of allele C relative to A was 0. 65, and the genetic pattern of allele C relative to A was dominant(P=0. 03)., Conclusion: The vitamin D-binding protein gene rs2282679 was significantly associated with serum vitamin D insufficiency and deficiency in college students, and A-allele is a risk factor accounting for vitamin D insufficiency and deficiency in college students.

Objective: To investigate curative effect and importance of radiofrequency thermocoagulation onsemilunar ganglion of aged patients with recurrent trigeminal neuralgia., Method: 112 cases with recurrent trigeminal neuralgia were performed with radiofrequency thermocoagulation on semilunar ganglion by puncture through skin under local anesthesia., Result: The maintaining effective duration in 112 cases was 7.3 ± 1.3 years after primary therapy. After the first thermocoagulation, 89.28% (100/112) patients got the relief from pain immediately, 8 (7.14%) cases also recieved the same effect after twice treatment. However two cases (2.6%) had no effects. The total effective rate was 98.21%. During five follow-up years, VAS scores, dose of carbamazepine and satisfaction were better than those before the treatment. The effective rate was still over 57.5% within three years after the treatment. The recurrent risk increased obviously from 40 months after the treatment by Kaplan-Meier method., Conclusion: Semilunar ganglion of radiofrequency thermocoagulation was an ideal option for old-age patients with trigeminal neuralgia. It can be performed repeatedly.

Background: To explore the significance of lung biopsy through CT-guided percutaneous paracentesis in the diagnosis of space-occupying lesions of the lung., Methods: Thirty-five patients with space occupying lesions of the lung underwent lung biopsy through CT-guided percutaneous paracentesis and DLTRA-CUT 16G, 18G or 20G soft-tissue-cutting biopsy needles and PICKER IQ computerized tomograph were used., Results: Of the 35 patients, 26 were confirmed by pathological examination to suffer from primary malignant tumor, 1 from metastatic carcinoma, 3 from tuberculosis and 3 from inflammatory pseudotumor. No definite diagnosis was made in two patients. The diagnostic rate was 94.3%. After operation, minor pneumothorax occurred in 5 cases and traces of blood in sputum in 2 cases, however, they didn't need any treatment., Conclusions: Lung biopsy through CT-guided percutaneous paracentesis is a safe and practical technique and may be widely used in hospitals if conditions permit.