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OBJECTIVE: To investigate the adverse drug reaction (ADR) reports of QT interval prolongation in ECG in Beijing, and to probe into the rules and characteristics of ADR, so as to provide reference for clinical safe medication. METHODS: A total of 92 cases of ADR of QT interval prolongation reported by institutions in Beijing from 2018 to 2022 were collected and analyzed in terms of types of ADR, patients' genders and ages, primary diseases and adverse reaction history, pharmacological classifications, drug properties, dosage forms and clinical outcomes. RESULTS: Among the 92 ADR reports of QT interval prolongation, 51 cases were female patients (55. 43%) and 41 cases were male patients (44. 57%); the largest number of patients were ≥65 years old, with 41 cases (44. 57%). A total of 100 times of medicine were enrolled, which were dominated by anti-infective drugs ( 44 cases ), antipsychotic drugs (28 cases) and cardiovascular drugs (10 cases); the top 3 drugs ranked by ADR cases were moxifloxacin (32 cases), amisulpride (15 cases) and amiodarone (7 cases); there were 13 kinds of drugs in both oral and injectable forms,with 45 cases of ADR were caused by intravenous dosage forms and 13 caused by oral dosage forms. In terms of ADR outcomes, 79 cases ( 85. 87%) were recovered and improved. CONCLUSIONS: In the combined application of injection of anti-infective drugs, oral administration of antipsychotic drugs, oral administration of cardiovascular drugs and drugs with adverse drug reactions of QT interval prolongation, especially for the elderly, females and those who have QT interval prolongation, it is necessary to pay attention to patients' ECG conditions and clinical signs and symptoms, and use informative early warning measure if necessary, to prevent the occurrence and progress of QT interval prolongation and to ensure medication safety by optimizing the therapeutic scheme. [ABSTRACT FROM AUTHOR]

Objective To investigate the effects of gender on dosage of remimazolam and quality of recovery in patients undergoing ambulatory arthroscopic surgery at 24 hours postoperatively. Methods Fifty patients who underwent elective arthroscopic meniscus repair in a daytime surgery center were divided into two groups according to gender: 25 males (group M) and 25 females (group F). The remimazolam dogages of loss of consciousness and anesthesia maintenance were recorded, and the effects of gender on the quality of recovery at 24 hours postoperatively and sleepquality were observed by using QoR-15 scale and Athens Insomnia Scale (AIS). Results The doses of remimazolam at the time of loss of consciousness and anesthesia maintenance for patients were (0.13 and 0.15) mg/kg and 0.80 (0.60 and 0.96) mg/ (kg·h) in group M, and 0.14 (0.12 and 0.16) mg/kg and 0.90 (0.79 and 1.12) mg/ (kg·h) in group F. There were no statistical differences in the doses of remimazolam between the two groups (P > 0.05). AIS scores did not differ on postoperative day one between the two groups (P > 0.05), but there was a statistically significant difference on final awakening earlier than expectation in the female patients (P < 0.05). Female patients had lower total QoR-15 scores and physiological comfort scores, and higher incidences of hypotension and PONV than male patients (P < 0.05). Conclusions Gender had no significant effects on dosage of remimazolam during anesthesia induction and anesthesia maintenance in the patients receiving daytime arthroscopy. Female patients had final awakening earlier than expectation, and male patients had higher quality of recovery at 24 hours postoperatively. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To investigate the clinical application of ceftazidime-avibactam (CAZ-AVI) in inpatients of the hospital, so as to provide reference for rational clinical application of CAZ-AVI. METHODS: Medical records of all inpatients with CAZ-AVI in the hospital from Jan. 2020 to Feb. 2022 were collected, and relevant information such as population characteristics, infection site, microbial examination and drug sensitivity test results, use and dosage of CAZ-AVI, drug combination and treatment results were analyzed. RESULTS: A total of 52 inpatients were treated with CAZ-AVI, including 40 male patients and 12 female patients. The age ranged from 23 to 95 years. The pathogenic detection rate before CAZ-AVI was 100%, and the results were mainly Gram-negative bacteria. Totally 43 case-times (accounting for 66. 15% of the total 65 case-times) received treatment according to the recommended dose of 2. 5 g every 8 hours. The antibiotics used in combination with CAZ-AVI were tigacycline, vancomycin, meropenem and levofloxacin. CAZ-AVI mainly combined with tigecycline for the treatment of lung, blood flow and abdominal cavity infections induced by multidrug resistant Klebsiella pneumoniae and other Gram-negative bacilli, and the efficacy was significant with few adverse drug reactions. CONCLUSIONS: The clinical application of CAZ-AVI in the hospital is rational, yet there are still some problems such as inaccurate dosage. In clinical treatment, it is necessary to strictly control the indications, pay close attention to the efficacy and adverse drug reactions, promote the rational application of antibiotics, and reduce drug resistance. [ABSTRACT FROM AUTHOR]

To study the reference range of olanzapine concentration in the treatment of schizophrenia. METHODS: According to inclusion and exclusion criteria, age, gender, daily dose, administration time, daily administration frequency, drug combination, scale score and adverse drug reactions of inpatients from Xi’ an Mental Health Center from Jun. 2016 to Mar. 2022 were collected. The correlation between olanzapine concentration and collection index was analyzed. The effective reference range of olanzapine concentration was determined, and the warning value was determined combined with the incidence of adverse drug reactions. RESULTS: There were statistically significant differences in olanzapine concentration among patients with different ages and daily doses (F= 1. 138, F= 1. 322; P<0. 05), the olanzapine concentration of male patients was significantly lower than that of female patients [(39. 29±24. 48)ng / mL vs. (49. 93±26. 92) ng / mL, Kolmogorov-Smirnov test = 0. 201 4, P<0. 01)]. Olanzapine concentration was positively correlated with daily dose ratio (r = 0. 225 4, t = 36. 36, P<0. 01), adverse drug reactions ( t = 2. 013, P<0. 05). According to the principle of maximum detection rate value, 30 ng / mL was the lower limit of the reference range (≥ threshold detection rate was 8. 561%), 90 ng / mL was the upper limit of the reference range ( < threshold detection rate was 2. 022%), 130 ng / mL was the alert value ( adverse drug reaction rate ≥70%). The detection rate of 15 ng / mL was better than 90 ng / mL ( threshold detection rate: 4. 187% vs. 2. 022%). CONCLUSIONS: There are individual differences in patients using olanzapine with different gender, age and daily dose, and the incidence of adverse drug reactions is high, so that olanzapine concentration should be routinely monitored clinically. It is recommended that 15 to 90 ng / mL be used as the reference range and 130 ng / mL as the alert value. [ABSTRACT FROM AUTHOR]

Objective: To investigate the risk factors of olfactory dysfunction in patients with chronic sinusitis and its effect on mental health and quality of life of patients. Methods: 120 patients with chronic sinusitis who were admitted to Beijing Tongren Hospital Affiliated to Capital Medical University from September 2017 to September 2020 were selected for olfactory function test. The incidence of olfactory dysfunction was analyzed, and patients were divided into olfactory dysfunction group (n=64) and olfactory normal group (n=56) according to the olfactory function test. The basic data, clinical data, mental health status and quality of life of patients in the two groups were compared and analyzed. The influencing factors of olfactory dysfunction in patients with chronic sinusitis were analyzed by univariate analysis, and risk factors of olfactory dysfunction in patients with chronic sinusitis were analyzed by multivariate Logistic regression. Results: According to the olfactory function test results, 64 of the 120 patients showed olfactory dysfunction, and the prevalence rate of olfactory dysfunction was 53.33%, included 36 cases (56.25%) of male patients, and 28 cases (43.75%) of female patients. 46 cases (38.33%) had hypoolfactory, and 18 cases (15.00%) had anosmia. Univariate analysis showed that nasal endoscopic surgery history, concomitant nasal polyp, asthma history, proportion of eosinophils and nasal endoscopic Lund-Kennedy score were the influential factors for the occurrence of anosmia in chronic sinusitis (all P<0.05). Multivariate Logistic regression analysis showed that nasal endoscopic surgery history, concomitant nasal polyp, asthma history, proportion of eosinophil ＞5%, and nasal endoscopic Lund-Kennedy score ≥2 scores were independent risk factors for olfaction of chronic sinusitis. The scores of anxiety self-rating Scale (SAS) and depression self-rating Scale (SDS) in the olfactory normal group were lower than those in the olfactory dysfunction group (P<0.05). The score of quality of life (SF-36) for each dimension in the olfactory normal group was higher than that in the olfactory dysfunction group (P<0.05). Conclusion: The incidence of anosmia is higher in patients with chronic sinusitis, and the risk factors for anosmia are nasal endoscopic surgery history, concomitant nasal polyp, asthma history, proportion of eosinophilia ＞5% and Lund-Kennedy score ≥2 scores. At the same time, olfactory disorder can also cause depression and anxiety and other adverse emotions, reducing the quality of life of patients. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To evaluate the clinical efficacy of lorlatinib in the treatment of non-small cell lung cancer (NSCLC) based on Meta-analysis method, and to probe into the clinical manifestations, characteristics, patterns and outcomes of adverse drug reactions (ADR) induced by lorlatinib, so as to provide references for the clinical safe medication. METHODS: By retrieving CNKI, Wanfang Data, PubMed, Web of Science and other database, randomized controlled trials (RCT) on lorlatinib in the treatment of NSCLC [the lorlatinib group was given lorlatinib regimen with or without other medication, and the control group was given the first and (or) the second generation of anaplastic lymphoma kinase (ALK)-tyrosine kinase inhibitor (TKI) regimen] were enrolled for Metaanalysis, and studies on ADR induced by lorlatinib were also analyzed. RESULTS: Totally 5 eligible RCT were enrolled, including 622 patients (308 cases in the lorlatinib group, 314 cases in the control group), the objective remission rate (ORR) was used as the main outcome indicator. The results of Meta-analysis showed that the ORR of the lorlatinib group was higher than that of the control group, with statistically significant difference(OR = 2. 31,95%CI = 1. 62-3. 28,P<0. 000 01), which indicated that the efficacy of lorlatinib was significant compared with the previous 2 generations of drugs. Fourteen cases of ADR induced by lorlatinib were also collected, including 6 male patients and 8 female patients; there were more patients in the age group of >60 to 70 years old, with 7 cases; most ADR occurred at 2 weeks after medication, mainly involved cardiovascular system damage and respiratory system damage; all ADR were improved after drug withdrawal and (or) symptomatic supportive treatment; 2 cases showed no improvement or aggravation of symptoms at recurrence. CONCLUSIONS: As the third generation of ALK-TKI to treat NSCLC, the level of loratinib to treat NSCLC was significantly improved. However, clinical application of lorlatinib requires strict monitoring on cholesterol and triacylglycerol levels, as well as vigilance against central nervous system damage and cross-adverse drug reactions in the early phase of drug administration. [ABSTRACT FROM AUTHOR]

Copyright of Imaging Science & Photochemistry is the property of Imaging Science & Photochemistry Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

OBJECTIVE: To probe into the clinical characteristics, therapeutic regimens and possible mechanism of interstitial lung disease induced by oxaliplatin. METHODS: MEDLINE, PubMed, Web of Science, SpringerLink, Ovid, Embase, Wiley Oline Library, CNKI, Wanfang data and VIP database were retrieved to collect literature of interstitial lung disease induced by oxaliplatin, the retrieval time was from the establishment of the database to Apr. 2022. Patients ’ general information, medication regimens, examination means, treatment and outcomes of the involved studies were extracted and analyzed descriptively. RESULTS: A total of 35 patients with interstitial lung disease induced by oxaliplatin were retrieved from 27 case reports; of which 26 were male and 9 were female; aged 30- 79 years. Among the 35 patients, 31 were treated with corticosteroids, of which 16 were improved and 15 were dead (including 14 male patients). The association of adverse drug reactions was evaluated as “very likely” (24 patients) and “possible” (11 patients). 19 patients were improved after drug withdrawal, dressing change and steroid hormone treatment, and no reoccurrence was observed during observation and follow-up periods. CONCLUSIONS: Interstitial lung disease induced by oxaliplatin occurs mostly in elderly male patients and has a higher mortality rate in male patients; which mostly occurs at a cumulative dose of oxaliplatin of 716.1 mg / m² over 8 cycles of drug combination. The lung function and imaging / radiology examination should be strengthened in patients treated with oxaliplatin, so as to detect adverse drug reactions as soon as possible and adjust the medication regimen in time. [ABSTRACT FROM AUTHOR]

Objective: To explore and evaluate the diagnostic effect of perfluorinated hysterosalpingography four-dimensional sonography (4D-HyCoSy) and transvaginal three-dimensional sonography (3D-HyCoSy) in patients with tubal infertility. Methods: From August 2018 to November 2021, A total of 84 cases of female infertility patients who were diagnosed and treated in our hospital were selected as the research subjects. All of them were diagnosed with perfluorinated 4D-HyCoSy and 3D-HyCoSy, and the image quality and the occurrence of untoward effect were recorded. Laparoscopy were used as the gold standard for diagnosis to determine the diagnostic effect. Results: The image quality rate of perfluorinated 4D-HyCoSy were 100.0 %, which were higher than 92.9 % of 3D-HyCoSy (P<0.05) in the 84 patients. Perfluorinated 4D-HyCoSy diagnosed 14 cases of tubal patency, 23 cases of tubal patency and 47 cases of tubal obstruction. 3D-HyCoSy diagnosed 22 cases of tubal patency, 21 cases of tubal obstruction, and 41 cases of tubal obstruction. Laparoscopic diagnosis were 15 cases of tubal patency, 21 cases of tubal obstruction, and 48 cases of tubal obstruction. The diagnostic sensitivity of perfluorinated 4D-HyCoSy and 3D-HyCoSy for tubal infertility patients were 100.0 % (36/36), 97.2 % (35/36), and the specificity were 97.9 % (47/48) and 83.3 % (40/48) . The adverse reactions of 84 patients during the examination of PFOS 4D-HyCoSy and 3D-HyCoSy were no difference in the incidence of untoward effect (P>0.05). Compared with 3D-HyCoSy, the diagnostic sensitivity of perfluorinated 4D-Hy CoSy in patients with tubal infertility were not different (P>0.05), and the diagnostic specificity were higher than that of 3D-HyCoSy (P<0.05) . Conclusion: Compares with 3D-HyCoSy, the application of perfluorinated 4D-HyCoSy in patients with tubal infertility can improve the image quality rate, it has good safety, and has better diagnostic specificity. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To investigate the medication on patients with systemic lupus erythematosus (SLE) in outpatient and emergency prescriptions in 9 cities in China, and propose reasonable suggestions, so as to provide reference for clinical rational drug use. METHODS: All the prescriptions of immunization drugs were randomly selected by quarter from 109 sample medical institutions in 9 cities including Beijing, Chengdu and Guangzhou from 2016 to 2020, the medication of patients were collected and analyzed. The defined daily dose (DDDs), defined daily cost (DDC) and growth rate of consumption sum of drugs for SLE were calculated, and then analyzed for the clinical application. RESULTS: A total of 480 886 prescriptions were enrolled in this study. The statistical results showed that the age of SLE patients was mainly >20 to 40 years old (222 492 person-times); there were more female patients (412 894 person-times) than male patients (47 373 person-times). From 2016 to 2020, the total consumption sum of drugs for SLE patients in 9 cities increased steadily, and the drug with the highest consumption sum was mycophenolate mofetil; the drug with the highest DDDs was prednisone, followed by hydroxychloroquine, and the DDDs of prednisone increased year by year from 2016 to 2019 (decreased in 2020), the DDDs of hydroxychloroquine increased year by year for the 5 years. CONCLUSIONS: The total consumption sum of therapeutic drugs for SLE patients in 9 cities in China from 2016 to 2020 shows an increasing trend; although the medication on SLE patients varies from each city, it is generally in line with the guideline recommended drug use; meanwhile, more attention should be paid to the safety of individual drugs. [ABSTRACT FROM AUTHOR]

Objective The effects of using a maxillary skeletal expander (MSE) on the orbital volume and width between periorbital bones in the treatment of adult female patients with maxillary transverse deficiency (MTD) were evaluated. Methods A total of 20 adult female patients with MTD with an average age of (22.60±6.29) years were included in the study. The patients were treated with MSE. Cone beam computed tomography was performed before expansion (T0) and no more than 3 weeks after expansion (T1). Orbital volume and periorbital bone width were measured with Mimics 21.0 and analyzed with SPSS 20.0. Paired t-test was performed, and a P value of <0.05 indicated significant difference. Results After expansion, the orbital volume increased by (346.80±275.31) mm³ (P<0.05). The width between the right and left zygomaticomaxillary sutures increased by (1.69± 0.57) mm (P<0.05), and the width between the right and left infraorbital points increased by (1.71±0.70) mm (P< 0.05). However, the width between the right and left frontozygomatic sutures increased by (0.15±0.32) mm (P> 0.05). Finally, the width between the right and left supra-orbital points increased by (0.23±0.52) mm (P>0.05). Conclusion The maxillary skeletal expander slightly expanded the orbital volume in the adult female patients and increased the lateral widths of the periorbital bones. [ABSTRACT FROM AUTHOR]

To explore the value of three-dimensional ultrasound technology in assessing pelvic floor muscle contraction and bladder neck mobility in female patients with stress urinary incontinence (SUI). Methods: 60 female patients with postpartum SUI admitted to our hospital from January 2020 to August 2021 were selected as the observation group, and 60 female subjects with normal postpartum during the same period were selected as the control group. All subjects underwent perineal three-dimensional ultrasound examine. The differences in related indexes such as pelvic floor muscle contraction and bladder neck mobility between the two groups were compared. Results: In the resting state and the maximum Valsalva state, the anterior and posterior diameter, the left and right diameters of the pelvic diaphragm hiatus, the area of the levator ani muscle and the posterior angle of the bladder neck in the observation group were significantly larger than those in the control group (P<0.05). The length of the urethra in the observation group was significantly lower than that in the control group (P<0.05); and only in the maximum Valsalva state, the bladder neck position of the observation group was significantly larger than that of the control group (P<0.05). In addition, the proportion of bladder funnelization in the observation group was significantly higher (P<0.05). Conclusion: Three-dimensional ultrasound technology can clearly and intuitively display the structure and function of the female pelvic floor. It has certain diagnostic value for assessing the pelvic floor muscle contraction and bladder neck mobility in female patients with SUI, and provides true and objective imaging evidence for the clinic [ABSTRACT FROM AUTHOR]

OBJECTIVE: To probe into the characteristics and regularities of the occurrence of allergic reactions induced by statins, so as to provide reference for clinical rational drug application. METHODS: Cases of allergic reactions induced by statins reported on the adverse dug reaction monitoring network in this hospital from Jan. 2015 to Mar. 2021 were selected, and literature related to allergic reactions induced by statins from Jan. 2000 to Mar. 2021 were retrieved from CNKI, W anfang Data and VIP database, and the cases were statistically analyzed. RESULTS : There were 4 cases of allergic reactions induced by statins reported in this hospital, and 26 case reports( 26 cases) of allergic reactions induced by statins were retrieved from the literature search, with a total of 30 cases ; among them, 19 cases(63. 33%) were male and 11cases(36.67%) were female; the ages of patients ranged from 32 to 85 years old, with a mean age of 61. 4 years old; the shortest time of allergic reactions was 5 minutes after oral administration, and the longest time was 6 months after continuous oral administration, of which 17 cases( 56. 67%) occurred ≤3 d after drug administration; allergic reactions included skin allergy( 19 cases), allergic shock ( 3 cases), angioneurotic edema ( 5 cases), drug fever( 2 cases), and allergic asthma( 1 case) ; 5 cases( 16. 67%) reported changing to other lipidregulating drugs as an alternative treatment regimen. CONCLUSIONS: Statins can lead to allergic reactions such as shock, angioneurotic edema and allergic asthma, so that attention to patient' s medication monitoring during administration should be paid, especially at the initial stage of first administration; and adverse reactions should be reported promptly; for patients whose benefits from statins outweigh the disadvantages, alternative treatment regimens of allergic reactions should be clarified to provide reference for clinical medication. [ABSTRACT FROM AUTHOR]

Objective： To analyze the clinical characteristics of skin hyperpigmentation induced by polymyxin B and possible mechanism involved. Methods: Case reports of skin hyperpigmentation induced by polymyxin B were retrieved from PubMed, EmBase, Cochrane Library, China Nat io nal Knowledge Infrasructure (CNKI) and W anfang Data Digitalization Journals. The obtained data combined with a case encountered in clinical work were summarized and analyzed. Results： 14 case reports involving 18 patients were retrieved, and there was another case encountered in clinical work, totalling 19 patients, of whom 12 (63.2%) were male patients, 4 (21.1%) were female patients and 3 (15.8%) were of unknown gender. Elderly patients ($65 years old) accounted for 26.3% • 3-29 days after medication, there occurred cases of polymyxin B-related skin hyperpigmentation, of which 14 (73.7%) occurred 14 days after medication. There were 9 patients with reported clinical outcomes, and the skin color of the 4 patients returned to normal 45 days to 3 months after cessation of the drug. The mechanism of skin hyperpigmentation induced by polymyxin B might be associated with histamine release, Langerhans cell proliferation, oxidative stress response and increased melanin synthesis by phenylalanine. Conclusion: Skin hyperpigmentation induced by polymyxin B is commonly seen in clinical practice, and the symptoms usually develop in the early stage after medication, mostly affecting the face and neck. The adverse drug reactions are reversible and the original skin color could return to normal several months after drug withdrawal. However, the possible mechanism involved remains unknown, which demands further research. [ABSTRACT FROM AUTHOR]

To study the effect of traditional Chinese medicine bath combined with halometasone cream on ceramide and barrier function of stratum corneum in patients with psoriasis. This study recruited 80 patients with psoriasis who were treated in the Dermatology Clinic of our hospital from March 2020 to May 2021. All patients were diagnosed with psoriasis vulgaris through clinicopathology. Among them, 52 were male patients and 28 were female patients. The patients were 23~72 years old, with an average age of 48.29±6.33 years old. The experiment was divided into two groups: the control group (conventional drug treatment) and the observation group (Chinese medicinal bath combined with Metone cream for treatment). Observe the recovery of the two groups of patients. Compare the overall severity of psoriasis patients according to PASI. The dryness and desquamation of the skin of patients were evaluated by DLQI score and VAS. The hydration degree and barrier function of the skin of patients with psoriasis were evaluated by capacitance detection and transepidermal water loss. Analyze Cer and Cer ([NP]/[NS]) in the stratum corneum cells of patients by reversed-phase-liquid chromatography-mass spectrometry. The protein expression of VEGFR-1 and VEGFR-2 in the diseased area of the patient was detected by Western blot. (1) 3 weeks before treatment, there was no difference in PASI scores between the two groups (P>0.05), and the PASI scores of the observation group at the 5th, 8th and 12th week were lower than those of the control group (P<0.05). (2) The DLQI and VAS scores of the observation group were lower than those of the control group (P<0.05). (3) Compared with the control group, the capacitance of the diseased skin of the observation group increased, and the transepidermal water level de- creased (P<0.05). (4) The Cer content and Cer ([NP]/[NS]) of the observation group were higher than those of the control group (P<0.05). (5) The protein expression of VEGFR-1 and VEGFR-2 in the observation group was lower than that in the control group. Chinese medicinal bath combined with halometasone cream can improve the content of Cer and the ratio of Cer ([NP]/ [NS] in patients with psoriasis to maintain the barrier function of stratum corneum cells, thereby improving dry skin and itching of patients. Ceramide and barrier function. [ABSTRACT FROM AUTHOR]

Objective: To analyze the clinical features and the biochemical indicators before and after surgery of different pathological types of patients with benign primary hyperparathyroidism primary hyperparathyroidism PHPT, and to explore their correlation and provide ideas for the diagnosis and treatment of the disease. Methods: A total of 56 benign PHPT patients undergoing surgical treatment were collected, and their clinical data and changes in biochemical indicators before and after surgery were retrospectively analyzed. The patients were grouped by postoperative pathological results, and the differences in clinical features and biochemical indicators were compared. Results: The patients were divided into four groups according to pathological types: 21 cases (37.5%) of parathyroid adenoma (PA group), 28 cases (50.0%) of parathyroid adenoma-like hyperplasia (PAH group), 5 cases (8.93%) of atypical parathyroid glands tumor-like hyperplasia (PAAH group), and 2 cases (3.57%) of parathyroid adenoma combined with parathyroid adenoma-like hyperplasia (PA+PAH group). The incidence of female in PHPT patients was significantly higher, male: female ratio was 1:5.22, and the proportion in the PAH group was significantly higher than that in the PA group (P>0.05). There was no significant difference in clinical manifestations in each group; there were not significantly differences in the blood calcium, blood phosphorus, and 25-hydroxyvitamin D3 among the four groups before operation. 66.67% of multiple lesions occurred in the PAH group, and there was significant difference among the four groups (x2=20.160a, P=0.000). The maximum diameter of postoperative pathological specimens in the PA group was significantly larger than that in the PAH group (P<0.05), but there was no statistical difference among the other groups (P>0.05). The value of PTH dropped rapidly after the intraoperative specimen was removed, and rose slightly on the first day after surgery; blood calcium showed a continuous downward trend after surgery. There was no significant difference in the decrease of PTH and blood calcium among the four groups(P>0.05). Conclusions: The incidence of benign primary hyperparathyroidism is high in the middle-aged and elderly women, especially in the PAH group. There is no difference in clinical manifestations of various pathological types. Many lesions were mainly concentrated in the PAH group. The level of PTH before operation in the PAAH group is the highest, so the follow-up of PTH after operation should be strengthened to the PAAH group of patients. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Modern Laboratory Medicine is the property of Journal of Modern Laboratory Medicine Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Imaging Science & Photochemistry is the property of Imaging Science & Photochemistry Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: At present, the measurement of axial trunk rotation angle is widely used to screen scoliosis. Whether this method is suitable for all types of scoliosis is still uncertain. OBJECTIVE: To study the correlation between axial trunk rotation angle and Cobb angle in different ages, genders, and types of idiopathic scoliosis patients, and provide theoretical basis for screening of idiopathic scoliosis. METHODS: Totally 203 idiopathic scoliosis patients aged from 4 to 18 years old were measured in Cobb angle and axial trunk rotation angle. According the age, gender and type, 203 subjects were divided into different groups, and the correlation between Cobb angle and axial trunk rotation angle was calculated in each group. RESULTS AND CONCLUSION: (1) There was a moderate correlation between axial trunk rotation angle and Cobb angle in 203 patients with idiopathic scoliosis (r=0.581, P=0.000). (2) According to age, there was no correlation between Cobb angle and axial trunk rotation angle in 4-9 years old idiopathic scoliosis patients (r=0.516, P=0.155). There was a moderate correlation between the two angles in patients aged 10-18 years (r=0.455, P=0.000). (3) According to type, there was a strong correlation between the axial trunk rotation angle and Cobb angle in patients with type I single curve (r=0.739), a moderate correlation between the two angles in patients with type II double curve (r=0.431), and a weak correlation between the two angles in patients with type III triple curve (r=0.399). The correlation decreased between axial trunk rotation angle and Cobb angle with the increase of the number of side bends. (4) According to gender, the correlation between Cobb angle and axial trunk rotation angle was higher in male patients (r=0.601) than that in female patients (r=0.598). [ABSTRACT FROM AUTHOR]

BACKGROUND: Dental arch shape is often considered as an important factor in oral treatment; however, there is no report on the construction of three-dimensional finite element models of different dental arches. OBJECTIVE: To establish the three-dimensional finite element models of maxillary dental arches including square, ovoid, tapered. METHODS: An adult female patient after orthodontic treatment was selected as the subject of this study and her CT data were analyzed used Mimics 20.0 software, Geomagic Studio (2014) software, UnigraphicsNX (10.0) software and ANSYS (18.2) finite element analysis software to generate a complete model of maxillary dental arch. Then, through the calculation of the equations of different dental arch shapes and guide the equations into established dental arch model, three-dimensional finite element models of square, ovoid and tapered dental arches were constructed. RESULTS AND CONCLUSION: A fourth-order polynomial function describing the dental arch shape was obtained and three-dimensional finite element models of square, ovoid and tapered maxillary dental arch were successfully constructed. Square arch had 398 098 nodes and 223 751 units, ovoid arch had 401 800 nodes and 226 177 units, and tapered arch had 404 434 nodes and 227 430 units. These will provide a reliable basis for subsequent biomechanical analysis and clinical practice. [ABSTRACT FROM AUTHOR]

Objective: To understand the distribution of female reproductive tract infection types, and to analyze the influence of reproductive tract infection on female serum inflammatory factors, sexual function and psychological state. Methods: 60 female patients with reproductive tract infections who were treated in our hospital from May 2016 to August 2018 were selected (study group), and 60 healthy women who came to our hospital for physical examination in the same period were selected (control group). The infection types of reproductive tract infection in the study group were analyzed, and the serum inflammatory factors, sexual function and mental state of the two groups were compared. Results: Cervicitis (33.33%) and nonspecific vaginitis (26.67%) were the most common types of infection in 60 patients with genital tract infection. The levels of serum tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8) in the study group were respectively (144.38± 31.85) ng/mL, (73.85± 15.73) ng/mL, and (218.64± 43.28) ng/mL, respectively, which were higher than (99.01± 22.25) ng/mL, (40.27± 10.52) ng/mL, (113.82± 26.08) ng/mL in the control group, the difference was statistically significant (P<0.05). Conclusion: The scores of sexual desire, orgasm frequency, sexual satisfaction, sexual anxiety, spousal climax frequency and spousal satisfaction in the study group were respectively (3.08± 0.92) scores, (4.38± 1.01) scores, (2.71± 1.07) scores, (3.66± 1.30) scores, (2.68± 1.01) scores, (2.95± 1.04) scores,which were lower than (3.84± 0.51) scores, (4.92± 0.32) scores, (3.87± 0.47) scores, (4.18± 0.54) scores, (3.82± 0.38) scores and (3.97± 0.41) scores in the control group, the difference was statistically significant( P<0.05). The scores of Health Questionnaire depression scale(PHQ-9) and Generalized Anxiety Rating Scale (GAD-7) in the study group were respectively (16.35± 5.88) scores and (13.87± 3.73) scores, which were higher than (5.15± 1.76) scores and (5.89± 1.39) scores in the control group, the difference was statistically significant (P<0.05). Cervicitis and nonspecific vaginitis are the main types of female reproductive tract infection, genital tract infection can lead to a significant increase the levels of serum inflammatory factors and a decrease in sexual function in female patients, at the same time, it also has a certain influence on the patient's psychological state, in clinical work, patients should be timely and effective intervention, so as to improve the patient's sexual function and psychological state. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To probe into the effect of intravenous chemotherapy combined with radiotherapy in breast cancer patients with recurrence of ipsilateral supraclavicular lymph node metastasis（ ISLM） without distant metastasis. METHODS: Case data of 61 female patients with recurrence of ISLM of breast cancer admitted into Beijing Friendship Hospital Affiliated to Capital Medical University from Jul. 2008 to Jul. 2019 were retrospectively selected.All the patients were given chemotherapy with antharcyclines or taxanes drugs for 6 to 8 cycles and healing radiotherapy. Radiotherapy was performed between the 3 rd and 4 th chemotherapy, patients with positive estrogen receptor, progesterone receptor or human epidermal growth factor receptor 2 were respectively given endocrine therapy or targeted therapy. Overall survival（ OS) and disease free survival（ DFS) were calculated by Kaplan-Meier method, and differences were inspected by Log-rank method. RESULTS: The clinical total remission rate of patients after radiotherapy and chemotherapy were 94%（ 51/54), the median progression-free survival and OS were respectively 31 and 45 months, the total survival rate in 5 years and DFS were respectively 38% and 22%. CONCLUSIONS: For the patients with recurrence of ISLM of breast cancer, intravenous chemotherapy combined with local radiotherapy is an optimizing choice. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To investigate the clinical application and adverse drug reactions of Annao tablets, and to analyze its potential risk factors in the course of drug administration, so as to provide reference for further standardizing clinical medication. METHODS: Medical record and medical orders of 546 patients treated with Annao tablets in Fuxing Hospital Affiliated to Capital Medical University(hereinafter referred to as “our hospital”) in 2019 were retrieved from hospital information system, retrospective research was adopted to analysis the basic information, disease diagnosis, clinical department, usage and dosage, drug combination and adverse drug reactions of patients, rationality analysis was conducted on the clinical application of Annao tablets in order to look for the relevant factors to adverse drug reactions. RESULTS: Among the 546 patients treated with Annao tablets, 257 cases were male (47. 07%), 289 cases were female (52. 93%); with the average age was (75. 18±18. 23) years old, 72. 34% (395 cases) were aged over 60 years old; mainly distributed in department of traditional Chinese medicine(195 cases, 35. 71%), department of neurology(170 cases, 31. 14%) and department of ICU(136 cases, 24. 91%); the high frequency diagnoses were respectively cerebrovascular disease and related diagnosis(295 cases, 54. 03%), high fever and related diagnosis (165 cases, 30. 22%), hypertension and related diagnosis(56 cases, 10. 26%); in terms of usage and dosage, 92. 31% (504 cases) had a single daily dose within the prescribed range of drug instruction; the course of treatment was concentrated in 7-30 days(442 cases, 80. 95%). In the medication records, 98. 17% of patients(536 cases) were given combined medication, with an average of 8. 53 drugs for combination; in terms of combined application of Annao tablets and western medicines, the high frequently used western medicines were respectively antiplatelet drugs, blood lipid regulating drugs and cerebrovascular drugs, the high frequently used antibiotics in drug combination was cephalosporins for accompanying infection; in the combined application of Annao tablets and traditional Chinese medicines, the most frequently used traditional Chinese medicines were blood-invigorating and stasis-removing, heatclearing and toxicity-removing, liver-pacifying and wind-extinguish. 9 cases of adverse drug reactions/ events occurred, with the incidence rate was 1. 65%; unreasonable indications, unreasonable usage and dosage, and unreasonable drug combination medication were probably the potential risk factors for adverse drug reactions of Annao tablets. CONCLUSIONS: There are problems of without TCM indications, overdose and unreasonable drug combination in the use of Annao tablets in our hospital, the medication review, propaganda and education on rational medication, and effective pharmaceutical intervention should be strengthened, and the liver and kidney functions of patients need to be monitored to reduce the occurrence of adverse drug reactions and promote clinical rational application. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To probe into the characteristics drug-induced thrombocytopenia (DITP) in the First Affiliated Hospital of University of Science and Technology of China (hereinafter referred to as "our hospital"),so as to provide reference for preventing clinical medication risk and improving rational medication.METHODS: Data of the 42 cases of DITP patients reported by our hospital from Jan.2018 to Jul. 2020 were collected and analyzed by Pareto method in terms of occupation,age and gender, categories of drug, administration route,clinical manifestations and treatment measures.RESULTS: Among the 42 cases of DITP, mainly reported by pharmacists (38 cases); there were21 male and 21 female patients; mainly aged ＞ 18-＜ 80 years old; 9 categories including 23 kinds of drugs were involved, of which antineoplastics had caused the most DITP cases (15 cases), antineoplastics, antibiotics,antiepileptics and antiplatelet drugs were the main factors; 5 ways of administration were involved, of which intravenous drip was the main factor; the DITP was mostly occurred during 1-14 days after medication (26 cases); 12 cases if DIPT were treated with drug withdrawal without symptomatic treatment, 30 cases were given symptomatic treatment,mainly given recombinant human interleukin-11 (rhIL-11) combined with platelet transfusion for treatment. CONCLUSIONS: When clinical application of drugs that may cause DITP, awareness of safe medication should be strengthened, platelet counts should be closely monitored, DITP should be detected as soon as possible and given symptomatic treatment to ensure clinical medication safety. [ABSTRACT FROM AUTHOR]

Copyright of Imaging Science & Photochemistry is the property of Imaging Science & Photochemistry Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Imaging Science & Photochemistry is the property of Imaging Science & Photochemistry Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the correlation between serum hydroxyl vitamin D level and fragile hip fractures. Methods The clinical data of 181 female fragile hip fracture patients (age ≥50 years), who were admitted to our hospital from January 2013 to December 2015 and undergone serum 25-hydroxyl vitamin D (25OHD) test, were analyzed retrospectively. The age, fracture site, serum 25OHD level and bone mineral density (BMD) of the patients, as well as the outcome of 67 patients followed up for at least one year, were recorded. The correlation between serum 25OHD level and these indices was observed. Results In 181 over 50 years old female patients with fragile hip fractures, there were 127 cases (70.2%) with vitamin D deficiency, 42 cases (23.2%) with vitamin D insufficiency, and 12 cases (6.6%) sufficient vitamin D. The serum 25OHD level in patients who were less than 75 years was markedly higher than that in patients over 75 years old. BMD level in patients with 25OHD over 20ng/mL was higher than in patients with 25OHD less than 20ng/mL. The serum 25OHD level in patients with femoral neck fractures was higher than in patients with inter-trochanter fractures, but the difference was not statistically significant. Among patients followed up within one year, the patients with 25OHD over 20ng/mL had lower fall rate, fracture rate, and all-cause mortality than those with 25OHD less than 20ng/mL, but the difference was not statistically significant. The outdoor action ability in patients with 25OHD over 20ng/mL was markedly higher than that in patients with 25OHD less than 20ng/mL. Conclusion Vitamin D deficiency and insufficiency are prevalent in elderly female patients with fragile hip fractures. Serum 25OHD level is correlated with age, BMD, and the outcome of the patients. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Modern Laboratory Medicine is the property of Journal of Modern Laboratory Medicine Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigation the relationship among the location, age and clinicopathological features of gastric cancer patients. Methods: The clinical data for 1200 patients with gastric cancer in our hospital from Jan 2008 to Dec 2017 were analyzed with SPSS 24.0, including pathogenic sites, age, gender, tumor size, Borrmann type, general type and pathological differentiation type. For enumeration data, x2 test is used. Results: In 113 cases of early gastric cancer, Most of tumors occurred at lesser curvature of antrum (60, 53.1%); lesser curvature of corpus (29, 25.7%); angulus (14, 12.4%); cardia (10, 8.8%). In the four groups, there was significant difference between pathogenic sites and gender (x2=2.37, P<0.05). There was no significant difference with age, tumor size, general type and pathological differentiation type; In 1087 cases of adanced gastric cancer, The most predilection site was antrum (608, 55.9%)， secondly gastric fundus and cardia (249, 22.9%) and gastric body (173, 15.9%). In the four groups divided according to predilection site, there was significant difference with gender (x2=5.32, P<0.05). There was no significant difference with age, tumor size, Borrmann type, pathological differentiation type. The patients were divided into three groups (A: ≦40, B: >40≦60, C: >60) according to different ages, the total proportion of male and female was 2.3:1. The proportion of each group was 1.1:1, 2.4:1, 2.9:1. There was significant difference between the three groups (x2=8.39, P<0.05); Through the comparison for the three groups of pathology differentiation types, was 91.7% at most. However, the ratio of well differentiated adenocarcinoma increased as the growth of the age, which was statistical significance with poorly differentiated adenocarcinoma (x2=16.74, P<0.05). There was no significant difference in the pathogenic sites groups in which the cases of location at lower third of stomach was most (649, 54.1%). There was no significant difference in the tumor size groups in which the cases of size (>2 cm≦5 cm) was most (567, 47.3%). There was also no significant difference in Borrmann type groups in which the cases of BorrmannⅢ was most (509, 46.8%). Conclusions: No matter early gastric cancer or advanced gastric cancer,the most common site is the small curve side of the gastric antrum; in the early gastric cancer, the higher the lesion location , the greater the propotion of female patients; in the advanced gastric cancer, the higher the lesion location, the greater the propotion of male patients; in addition, the younger age of gastric cancer patients, the greater propotion of women; the older gastric caner patients are, the higher proportion of highly and moderately diferentiated adenocarcinoma is. No significant correlation was found between the location and clinicopathological features of gastric cancer. [ABSTRACT FROM AUTHOR]

Objective: To investigate the chromosome abnormity and its related factors in early abortion tissue from ART patients. Methods: A retrospective analysis was performed on the early abortion tissue from 409 cases of ART patients from2013 to 2017, and the relationship between embryo chromosome aneuploidy and female age, infertility years, infertility factors and ovulation promotion index were analyzed. Results: In 409 cases of ART patients, the percentage of embryo chromosome aneuploidy in abortion tissue was 57.46%, in which the top three proportion was 16 trisomy (23.95%), 22 trisomy (13.45%) and Turner (9.24%). The average age of female patients with chromosome aneuploidy embryo was significantly older than that of female patients with chromosome euploidy embryo(P<0.001). The average age of female patients with 16 trisomy embryo was significantly youngerr than that of female patients with 22 trisomy embryo (P<0.01) and that of female patients with Turner embryo (P<0.05). The average gonadotrophindose in patients with 16 trisomy embryo was less than that of patients with 22 trisomy embryo(P<0.05). The HCG level on the 15th day after transplanting in patients with 16 trisomy embryo undered that in patients with 22 trisomy embryo(P<0.05) and that in patients with Turner embryo (P<0.01). Conclusion: The occurrence frequency of embryo chromosome aneuploidy in early abortion tissue from ART patients had a positive correlation with the female age. However, the occurrence frequency of 16 trisomy and Turner embryo showed no correlation. Furthermore, the 16 trisomy embryo was a more likely factor resulting in early abortion. [ABSTRACT FROM AUTHOR]